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BIOL/BMSC 114
Dr Joy McIntosh, Reproduction Group VUW
(Refs: Chapter 43 Campbell and Reece)
Lecture overview:
and Eosinophils
interstitial
fluid
systems. *
Neutrophils
Erythrocytes
Macrophages
*
Dendritic cells
Platelets Monocytes
* *
Leukocytes and type of immunity
• Eosinophils
• Basophils (blood)
• Neutrophils Innate,
• Monocytes (blood) in all
phagocytes animals
• Macrophages, dendritic cells (tissue)
• Lymphocytes ---- natural killer cells
---- B cells Acquired
---- T cells only,
vertebrates
LE 43-5
The Lymph System Interstitial Lymphatic
fluid capillary
Adenoid
1. Blood
3.Lymph Tonsil
to lymph
returns
to blood Blood
Lymph capillary
nodes
Appendix
2. Cells
group at
nodes
Lymphatic
vessels Lymph Masses of
node lymphocytes and
macrophages
Phagocytic leukocytes:
macrophage
yeast cell
3 µm
3) Anti-microbial peptides and proteins:
• Cell membrane Toll-like receptors recognise
and bind to pathogen, triggering synthesis and
release of anti-microbial peptides and proteins.
• These proteins lyse/burst pathogens and/or
limit their reproduction.
• 3 main groups of anti-microbial proteins:
1) Defensins released after Toll-like receptor Found in all
binding. Pathogen cell membranes are animals.
damaged, causing their lysis.
2) interferons found only in
3) complement proteins vertebrates.
Interferons = glycoprotein cytokines
• are cytokine hormones that regulate activity of immune cells
locally.
• stimulate defense against viruses, tumours and parasites.
• Are lymphocytes
• Newly formed
lymphocytes are alike
but later develop into B
cells or T cells,
depending on where
they mature.
Pathogenic cell
presenting different
(
B antigens on its cell
surface.
Binding
lymphocytes and
T ( Response
• B and T cells each have about 100,000 cell surface receptors that
bind to foreign molecules = antigens on pathogens.
• Receptors bind only to a small portion of the antigen (about 4 amino
acids) called an epitope. Each antigen usually has many epitopes.
• Lymphocyte receptors are actually antibodies
• All receptors on one lymphocyte are the same, recognising only one
epitope, but other lymphocytes have other receptors.
Antibodies, antigens and epitopes
• antibodies = immunoglobulin proteins exist as:
-- antigen receptors on cell surfaces of B and T cells
-- free, soluble antibodies secreted by plasma B cells.
epitope
Antigen molecule
• Question:
How does the diversity seen in the known 1014
different B cell antibodies and 1017 different T cell
antibodies arise from the 20,500 protein-coding genes
in the human genome?
4) Mutation of
hypervariable
regions. Fig. 43.13 in text
2) Origin of self-tolerance
Fig. 43.14
in text
Primary and secondary immune responses