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Investigation performed at the Department of Orthopaedic Surgery, Saint Louis University School of Medicine, St. Louis, Missouri
Background: Exact determinants of hip instability have not been established for fractures of the posterior wall of the
acetabulum involving £50% of the wall. Therefore, examination of the hip under anesthesia (EUA) is routinely performed.
Recently, the superior exit point of the fracture has been reported to be an important identifiable risk factor. Pre-existing
adult hip dysplasia (developmental dysplasia of the hip [DDH]) is thought to have a similar role. The purpose of this study
was to determine if any known radiographic measurements and signs associated with DDH, or any fracture character-
istics, are independent risk factors for hip instability after fracture of the posterior wall of the acetabulum.
Methods: All patients with a posterior acetabular wall fracture (OTA 62.A1) treated at our institution between 2004 and
2015 were considered for the study. Inclusion criteria were an age of ‡18 years, an isolated posterior acetabular wall
fracture involving £50% of the acetabular wall, adequate imaging, and documented EUA results. Evaluated variables
included fracture fragment size, superior exit point of the fracture, center-edge angle, acetabular index, Tönnis angle,
lateralized head sign, crossover sign, posterior wall sign, ischial spine sign, and hip version. Data were examined using
univariate testing, followed by a multivariate logistic regression analysis.
Results: Sixty-eight patients met all of the inclusion criteria. Univariate analyses identified the posterior wall sign (p =
0.033), ischial spine sign (p = 0.030), and proximity of the superior exit point of the fracture to the acetabular dome (p =
0.044) as having a significant association with hip instability. However, multivariate logistic regression modeling revealed
that none of these factors were significant independent risk factors.
Conclusions: Consistent with previous studies, univariate analyses identified certain radiographic findings as significant
risk factors for hip instability in the setting of a fracture of the posterior wall of the acetabulum. However, subsequent
multivariate logistic regression modeling showed that no studied variable was an independent risk factor. Our results
indicate that important factors leading to hip instability are yet to be identified or the contributions of the measured
variables are relatively small. Therefore, EUA should remain the main clinical determinant of hip stability status.
Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
F
ractures of the posterior wall of the acetabulum are the outcome after nonoperative treatment of the fracture7. Frac-
most common acetabular fracture type, accounting for tures with instability of the hip joint on EUA, or those with
approximately one-quarter to one-third of all acetabular subluxation of the femoral head at presentation, are treated
fractures1-3. Computed tomography (CT) is routinely used for with open reduction and internal fixation (ORIF)7.
the evaluation of these injuries1-6. Using CT, if £50% of the Adult developmental dysplasia of the hip (DDH) and
wall is fractured, the stability status of the hip is uncertain4,5. femoroacetabular impingement (FAI) have been found to have a
Therefore, patients are routinely taken to the operating room role in posterior hip dislocation because of disease-specific
for examination under anesthesia (EUA) with the use of dy- morphologic features8,9. The association of posterior instability
namic stress views to determine further treatment4-6. A finding of the hip joint with femoral shaft version, acetabular version,
of stability on EUA is predictive of hip joint congruity, excellent and pre-existing pathologic conditions of the hip has been
radiographic outcome, and a good to excellent early clinical studied, with findings indicating that reduced femoral shaft
Disclosure: No external funding was received for this study. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of
the article (http://links.lww.com/JBJS/E466).
anteversion and intra-articular labral and chondral pathologies dislocated). The best-quality anteroposterior radiograph ob-
play a role in posterior hip dislocation2,3,8,10. FAI morphologic tained prior to or following EUA was used in the evaluation of
features such as a cam deformity or a retroverted acetabulum the following data: center-edge angle, acetabular index, Tönnis
also may play a role in traumatic posterior dislocations2. angle, lateralized head sign, crossover sign, posterior wall sign,
Therefore, there may be a relationship between hip dysplasia and and ischial spine sign8,13. In addition, all patients had Judet
instability after a fracture of the posterior wall of the acetabulum. oblique pelvic radiographs obtained before EUA to provide
A variety of radiographic markers and signs are commonly used further evaluation of hip joint congruency as well as infor-
to diagnose hip dysplasia. To our knowledge, no statistical cor- mation regarding the posterior wall fracture characteristics and
relations or associations have been established between these displacement. The contralateral hip was used for the evaluation
markers of dysplasia and hip stability status after a posterior of the posterior wall sign when the size, displacement, or
acetabular wall fracture. Recently, however, the proximity of the location of the ipsilateral posterior wall fragment obscured
superior exit point of the fracture to the acetabular dome was adequate evaluation. If a hip dislocation was present, only post-
reported to be an important identifiable risk factor11. Although reduction imaging was used for data gathering.
this is not a marker of dysplasia, it is a readily measurable Each patient had a high-quality CT scan (£2-mm slice
fracture variable and was of particular interest in our study. thickness with bone windows) performed before the EUA but
The purpose of the current study was to determine if any after any associated hip dislocation had been reduced. Analysis of
known radiographic measurements and signs associated with these CT scans provided details of hip version, fracture fragment
pre-existing DDH or fracture characteristics are independent size, and superior exit point of the fracture. CT scans were not
risk factors for hip instability after fracture of the posterior wall used in the evaluation of other dysplasia markers or signs8,13.
of the acetabulum. We hypothesized that independent risk Acetabular version was determined by the method of Reynolds
factors would not be identified. et al., using a reference line drawn between the center of the pubic
symphysis and the center of the sacrum14. The angle formed by a
Materials and Methods line parallel to this reference line and a line drawn between the
calculated from the ratio of the measured depth of the fractured For data analyses, all data were recorded as categorical
segment to the depth of the intact, matched contralateral ace- variables, with the exception of acetabular version, fracture
tabulum (Fig. 2). The superior exit point was determined by the fragment size, and the superior exit point of the fracture, which
method utilized by Firoozabadi et al.11. The superior exit point of were recorded as continuous variables. The center-edge angle,
the fracture line was located where the fracture exited the ace- Tönnis angle, and acetabular index were classified categorically as
tabulum’s articular surface. The superior exit point only refers to “dysplastic” or “normal” on the basis of the following definitions
the intra-articular fracture exit point, as the extra-articular of dysplasia: center-edge angle of <25°, Tönnis angle of >10°, and
component can exit above or below the joint involvement. A acetabular index of >40°13,16. The femoral head was described as
fracture exiting the acetabular dome was labeled as having a 0- “located” or “dislocated.” All classic radiographic dysplasia signs,
mm exit point11. The exit point in millimeters was identified including the posterior wall, ischial spine, lateralized head, and
primarily using axial images. Sagittal and coronal slices of the CT crossover signs, were described as “present” or “absent” as ob-
scan were used to cross-reference this value, when needed. All served with the use of traditional anteroposterior pelvic radio-
evaluated CT scans were obtained after any associated hip dis- graphs8,13,15. The posterior wall sign is present when the rim of the
location had been reduced. posterior wall is medial to the center of the femoral head15. The
During the time frame of the study, 79 patients were ischial spine sign is present when the ischial spine is shown to
identified as having undergone an EUA for a fracture of the protrude into the true pelvis8. The lateralized head sign is present
posterior wall of the acetabulum. Eleven were excluded ac- when the medial aspect of the femoral head is >10 mm from the
cording to the selection criteria. Of these 11 patients, 7 had an ilioischial line. The crossover sign is present if the separate lines of
ipsilateral femoral fracture, 1 had undergone a contralateral total the posterior wall and anterior wall converge, making a figure of
hip arthroplasty, and 3 had missing radiographs or CT imaging, 8 on anteroposterior imaging13. For each patient, the findings for
leaving a total of 68 patients with an isolated posterior acetabular these variables were compared with the recorded EUA result,
wall fracture (OTA 62.A1) for study. Ipsilateral limb injuries which identified the hip joint as being “stable” or “unstable.”
were excluded, as these injuries typically make EUA difficult,
thereby possibly compromising EUA results and quality. Statistical Analysis
The mean patient age was 34.0 years (range, 18 to 79 The final data were analyzed by a PhD-level statistician using the
years; median, 29.5 years). Forty-six (67.6%) of the patients appropriate parametric and nonparametric tests, depending on
were male and 22 (32.4%) were female. All patient injuries the variable type. Initially, all variables were evaluated with uni-
were due to a high-energy mechanism; for the vast majority, variate analyses. The Student t test was used for the continuous
this was a motor-vehicle collision. variables of acetabular version, fracture fragment size, and
Fig. 2
The method of measuring posterior wall fragment size is shown. Fig. 2-A Fractured acetabulum. The approximate medial-lateral dimension (depth) of the
fractured segment was determined at the level of the largest posterior wall deficit. Fig. 2-B Contralateral, intact acetabulum. The percentage of fragment
size was calculated from the ratio of the measured depth of the fractured segment to the depth of the intact acetabulum measured to the medial extent of the
quadrilateral plate.
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Estimated
Variable Statistical Test OR (95% CI)* T Value (95% CI)* P Value Power
superior exit point of the fracture, while a Pearson chi-square test ranged from 14% to 48% (mean, 34.8%; 95% CI, 29.1% to
was used for all other variables. Subsequently, a forward multi- 40.5%). Among the evaluated fracture characteristics, only the
variate logistic regression model was built using only the variables proximity of the superior exit point of the fracture to the ac-
found to be significant in the univariate analyses and applied to etabular dome (overall range, 0 to 30 mm; mean, 4.55 mm) was
describe the association between the measured risk factors and a significant indicator of hip instability in the initial univariate
hip instability. The level of significance was defined as p < 0.05. analysis (p = 0.044, t test) (Table I). Among the stable hips, the
mean distance of the exit point from the dome was 5.57 mm
Results (range, 0 to 30 mm; 95% CI, 3.66 to 7.49 mm). Among the
No. (%) of
Subjects with No. (%) of No. (%) of
Dysplastic Hip Presence of Subjects with Subjects with an
Variable Dysplasia Sign* a Stable Hip† Unstable Hip† P Value‡
*The percentage is of the total number of patients (n = 68). †The percentage is of the number of hips in which the dysplasia sign was present.
‡Derived from univariate analysis.
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wall sign, approximately one-quarter of hips had posterior ac- acetabular wall fractures are significant risk factors for hip
etabular wall fracture fragments that were sufficiently large or instability. However, the data did not fit the subsequent for-
displaced to warrant evaluation of the contralateral hip as a ward multivariate logistic regression modeling, and none of
substitute for the ipsilateral hip. Therefore, the assumption was the studied variables reached significance. Logistic regression
made that hip dysplasia, if present, was bilateral. This assump- modeling was chosen for this analysis because the dependent
tion was a potential study limitation. However, a number of variable of interest (stable or unstable) was binary and lo-
studies have provided widely varying data regarding the rate of gistic regression is a powerful, nonparametric statistical test
bilateral hip dysplasia, ranging from 4% to 84%20,21. Because the that does not require many of the assumptions of typical
range is so large, we decided that this was an acceptable limita- regression. Logistic regression was first performed with just
tion and justified the analysis of the posterior wall sign using the continuous variables; next, a mixed set of continuous and
contralateral hip, when necessary. nominal level variables was analyzed to predict stable or
Another potential limitation was the relatively small unstable fractures. None of the models successfully predicted
sample size for this study. However, the overlap in the data of hip joint instability. This finding leads to the conclusions that
these 2 groups (stable and unstable hips) indicates that a very the studied factors cannot be used to predict instability and
large sample size is required to ultimately test if there is any other factors not in the study may contribute to instability.
difference that can be reliably replicated across samples. When Therefore, these conclusions support the original hypothesis
models require very large sample sizes to detect these differences, that fracture fragment size alone or fracture fragment size in
the effect size is generally small and the clinical application be- combination with other measures, such as Tönnis angle,
comes irrelevant. Furthermore, the power estimates on the 3 acetabular index, anteversion, or proximity of the fracture
significant variables showed adequate power (Table I), while the exit point to the dome, cannot dependably predict stability or
model did not show significant predictive results. In addition, instability of the hip.
the findings of the Nagelkerke R2 and the Hosmer-Lemeshow In summary, with the sample size available, we found all
test indicated that the model was sufficient and that the study of the studied variables to be nonsignificant as independent risk
findings were not due to lack of power in the sample. None- factors for hip instability after a fracture of the posterior wall of
theless, while we believe that the results support the lack of the acetabulum. The results of this analytic approach indicate
predictor variables that may be used clinically to identify stability that important factors leading to hip instability have yet to be
versus instability, there is no doubt that our sample size was identified, or the contributions of the measured ones are
small for this type of analysis. In conducting the logistic re- relatively small. We cannot exclude the possibility that other,
gression analysis, dividing a small number of outcomes into yet undetermined, factors play an important independent role.
different cells may have created the discrepancy with the initial These undetermined factors could possibly be related to
analysis. Therefore, it may be possible to find a significant in- proximal femoral dysplasia, labral pathology, or capsular
dependent predictor with a larger sample size of unstable hips; injury. Additional studies are warranted to examine these
however, the sample size required is unknown. variables. However, at the present time, EUA remains the only
The retrospective method of this report constitutes an ad- reliable diagnostic method for determining hip stability status
ditional study limitation. However, we believe that this issue was after a fracture of the posterior wall of the acetabulum.
offset by the quality and quantity of the collected data. At our Therefore, EUA should remain as the main clinical determi-
institution, data on patients treated using EUA were prospectively nant of hip stability status. n
recorded. The CPT codes were used to identify the patients for NOTE: The authors thank Heidi A. Israel, PhD, for her assistance with the statistical analysis.
this particular study. Because of the data storage methods at our
institution, we were able to study many more factors than in
previous studies. In this way, the application of logistic regression
analysis permitted the identification of any independent risk Jay H. Patel, MD1
factors of hip instability, if they existed. To the best of our Berton R. Moed, MD1
knowledge, no previous studies have used this method to 1Department of Orthopaedic Surgery, Saint Louis University School of
examine DDH and fracture variables and their relationship to
Medicine, St. Louis, Missouri
instability in the setting of fracture of the posterior wall of the
acetabulum. E-mail address for B.R. Moed: moedbr@gmail.com
Consistent with previous studies, univariate analyses
showed that certain radiographic findings in posterior ORCID iD for B.R. Moed: 0000-0003-4908-8181
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