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Volume 143, Issue 4

October 1983 , pp. 332-337

Cavernosal Alpha-Blockade: A New Technique for Investigating

and Treating Erectile Impotence
(a1)
G. S. Brindley
https://doi.org/10.1192/bjp.143.4.332
Published online: 29 January 2018

Summary
Intracavernosal injection of phenoxybenzamine, in a dose too small to have significant general effects,
caused full erection lasting between half an hour and 30 hours in 3 of 4 potent men (2 normal, 2
anorgasmic) and in 6 of 11 impotent men. In the remaining potent man and 3 of the remaining
impotent it caused the penis to be stiff enough for intromission. Six of the eleven impotent men have
had sexual intercourse, for the first time for months or years, while under the drug.

The practical implications of this new discovery are discussed.

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Copyright
COPYRIGHT: © 1983 The Royal College of Psychiatrists

References Hide All

Brindley, G. S. (1981) Electroejaculation: its technique, neurological implications and uses.
Journal of Neurology, Neurosurgery and Psychiatry, 44, 9–18.
CrossRef (http://dx.doi.org/10.1136/jnnp.44.1.9) |
Google Scholar (https://scholar.google.com/scholar_lookup?
title=Electroejaculation:+its+technique+neurological+implications+and+uses&publication+year=1981&author
| PubMed (https://www.ncbi.nlm.nih.gov/pubmed/6451670)

Brindley, G. S. (1983) Physiology of erection and management of paraplegic infertility. In Male

Infertility (ed. Hargreave, T. B.). New York: Springer.
Google Scholar (https://scholar.google.com/scholar_lookup?
title=Physiology+of+erection+and+management+of+paraplegic+infertility&publication+year=1983&author=B

Brindley, G. S. & Gillan, P. (1982) Men and women who do not have orgasms. British Journal of
Psychiatry, 140, 351–6. CrossRef (http://dx.doi.org/10.1192/bjp.140.4.351) |
Google Scholar (https://scholar.google.com/scholar_lookup?
title=Men+and+women+who+do+not+have+orgasms&publication+year=1982&author=Brindley+G.+S.&autho

Boreham, P. F., Braithwaite, P., Milewski, P. & Pearson, H. (1977) Alpha-adrenergic blockers in
prostatism. British Journal of Surgery, 64, 756–7.
CrossRef (http://dx.doi.org/10.1002/bjs.1800641019) |
Google Scholar (https://scholar.google.com/scholar_lookup?title=Alpha-
adrenergic+blockers+in+prostatism&publication+year=1977&author=Boreham+P.+F.&author=Braithwaite+P.
| PubMed (https://www.ncbi.nlm.nih.gov/pubmed/72581)

Caine, M., Perleberg, S. & Meretyk, S. (1978) A placebo-controlled double-blind study of the
effect of phenoxybenzamine in benign prostatic obstruction. British Journal of Urology, 50, 551
–4. CrossRef (http://dx.doi.org/10.1111/j.1464-410X.1978.tb06210.x) |
Google Scholar (https://scholar.google.com/scholar_lookup?title=A+placebo-controlled+double
blind+study+of+the+effect+of+phenoxybenzamine+in+benign+prostatic+obstruction&publication+year=1978
410X.1978.tb06210.x)
| PubMed (https://www.ncbi.nlm.nih.gov/pubmed/88984)

Polak, J. M., Gu, J., Mina, S. & Bloom, S. R. (1981) Vipergic nerves in the penis. Lancet, ii, 217–19.
Google Scholar (https://scholar.google.com/scholar_lookup?
title=Vipergic+nerves+in+the+penis&publication+year=1981&author=Polak+J.+M.&author=Gu+J.&author=Min

Wagner, G. & Brindley, G. S. (1980) The effect of atropine, α- and β-blockers on human penile
erection: a controlled pilot study. In Vasculogenic Impotence (eds. Zorgniotti, A. and Rossi, G.).
Springfield, Illinois: Charles C. Thomas.
Google Scholar (https://scholar.google.com/scholar_lookup?title=The+effect+of+atropine+%CE%B1
blockers+on+human+penile+erection:+a+controlled+pilot+study&publication+year=1980&author=Wagner+G