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Br J Nutr. 2006 Oct;96(4):660-6.

Anti-diabetic and hypolipidaemic properties of ginger (Zingiber

officinale) in streptozotocin-induced diabetic rats.
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Al-Amin ZM1, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M.
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Abstract
In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied Similar articles
in rats. An aqueous extract of raw ginger was administered daily (500 mg/kg, intraperitoneally) Anti-diabetic activity of Zingiber
for a period of 7 weeks to streptozotocin (STZ)-induced diabetic rats. Fasting blood serum was officinale [J Pharm Pharmacol. 2004]
in streptozotocin-
analysed for blood glucose, cholesterol and triacylglycerol levels. The STZ-injected rats
Effect of ethanolic extract of
exhibited hyperglycaemia accompanied with weight loss, indicating their diabetic condition. At Zingiber[Jofficinale
Ethnopharmacol.
on 2005]
a dose of 500 mg/kg, raw ginger was significantly effective in lowering serum glucose,
Possible antidiabetic and
cholesterol and triacylglycerol levels in the ginger-treated diabetic rats compared with the
Clin Exp Pharmacol Physiol.
antihyperlipidaemic effect of2006]
control diabetic rats. The ginger treatment also resulted in a significant reduction in urine
protein levels. In addition, the ginger-treated diabetic rats sustained their initial weights during Review Ginger: an
the treatment period. Moreover, ginger decreased both water intake and urine output in the Drug Metabol Drug
ethnomedical, Interact.
chemical and2001]
STZ-induced diabetic rats. The present results indicate that raw ginger possesses Review Zingiber officinale and
hypoglycaemic, hypocholesterolaemic and hypolipidaemic potential. Additionally, raw ginger is Crit TypeRev EukaryotMellitus:
2 Diabetes Gene Expr. 2...]
effective in reversing the diabetic proteinuria observed in the diabetic rats. Thus, ginger may
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be of great value in managing the effects of diabetic complications in human subjects.
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PMID: 17010224
[Indexed for MEDLINE]
Cited by 34 PubMed
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