Paguidian, Griffin John D.

PATHOPHYSIOLOGY
BSN IVA

MODIFIABLE NON-MODIFIABLE
 Lifestyle  Age – 53 y/o
- substance abuse  Gender - Male
(methamphetamine)
- Alcohol intake
- Smoking

SUBSTANCE ABUSE

Chronic alcoholism A Cigarette smoking

Chronic use of
Methamphetamine
Nicotine enters the blood stream
and attaches to the endothelial
Increased stimulation of lining of the blood vessel
the increase in
production of dopamine
by the pituitary gland Blockage or toral
occlusion of blood flow
Increased release of to the target organ
dopamine (brain)

Inflammatory respone of
Overproduction of
the endothelial lining of
dopamine overcomes
the affected blood vessel
the available receptros

Uncontrolled sensation Vasoconstriction

of pleasure

Increased activity of the brain Decreased oxygen

due to dopamine over load reaching brain tissue

Overstimulation Tissue damage

 Paguidian, Griffin John D. PATHOPHYSIOLOGY
BSN IVA

Alteration in function of Neuronal death

neurotransmitters,
specifically dopamine Decreased brain volume
Altered thought
process
Positive & Negative Symptoms
of Paranoid Schizophrenia
perseveration

Motor deficit

Blunted affect Aggression or violent

delusions
behavior

(shouting, swearing)

Overstimulation caused
by increased dopamine
Teeth grinding Imagined crawling insects
under the skin
Poor dental Decreased
hygiene appetite

Dry mouth Picking & scratching of

Poor nutrition skin

dehydration

Tooth decay Weight loss

Drying skin
Skin sores

Impaired Decreased
nutrition Imbalanced nutrition: elasticity and
less than body integrity of skin
requirements

Impaired skin
integrity
 Paguidian, Griffin John D. PATHOPHYSIOLOGY
BSN IVA

Exposure to toxic
Chronic substances Chronic
smoking (Methamphetamine alcoholis
) m

Destruction of cells Circulation of free

radicals in the body
Production of new cells
exceeds the limit of control
of the body Intracellular
damage to cells

Uncontrolled
Gene p53 unable to cell division
compensate with
increased proliferation
of dividing abnormal Cell mutation
cells

1
 Paguidian, Griffin John D. PATHOPHYSIOLOGY
BSN IVA
1

Accumulation of abnormal Decreased/Lack of

Accumulation of abnormal sufficient tumor suppressor
cells within the membrane
cells within the brain Genes (p53)
of the brain (meninges)

Enlarging mass near 4.8cm x 5.0cm x

Meningioma the left temporal fossa 5.7cm

The mass lies Compressed Decreased

flat against the tissue of the oxygen supply to
sphenoid bone hypothalamus the hypothalamus

Increased pressure Affectation of the

within the skull and sleep-wake cycle
Vasogenic Edema
nearby brain tissue (Circadian rhythm)

Shifting of fluid into Decreased Patient always

intracellular or extracellular Increased intracranial sensorium asleep / lethargic
spaces of the brain pressure

Severe compression Moderate compression Compression of Left to right midline shifting

of the left lateral of the right lateral brain tissue on the of 1.4cm due to edema and
ventricle of the brain ventricle of the brain left temporal lobe increased ICP

Decreased supply Increased

Temporal lobe pressure on left
of CSF
decompressed due to and right temporal
increased ICP causes its lobes causes the
Decreased cushioning of the brain function to be compromised uncus to squeeze
tissue, slow removal of waste, or depressed out of its position
decreased circulation of nutrients
into the brain
Impending
Broca’s uncal
Agnosia Wernicke’s herniation
Aphasia aphasia