Key messages

The bliss of herbal medicinal shrub like Withania somnifera (Ashwagandha) on rejuvenating

male infertility has its deep rooted mechanisms. The direct and indirect mechanisms of the same

explain how it mitigates factors that induce male infertility.

Withania sominifera roots improve semen quality by increasing sperm count and motility,

regulating reproductive hormone levels and inhibiting lipid peroxidation. Proposed mechanisms

underlying these effects are direct alleviation of oxidative stress as well as enhancement of

hormonal balance via the GABA-mimetic pathway. Withania sominifera could potentially

supplement the routine treatment of male infertility.