ASSIGMENT IN IMMUNOLOGY LECTURE

1. WEEKLY HOMEWORK
2. JOURNAL READING
3. FINAL EXAMINATION

WEEKLY HOMEWORK
• Problem/Questions will be given 1 week before lecture
• Collected on the day of the lecture
• Each student worked on their own (independent), hand writting.

JOURNAL READING (JR) PRESENTATION

Students sought their own 1 Immunology Research Journal, published in the last 2 years, and
approved by the lecturer.
Activities include presentations (20 minutes) and discussion (10 minutes)

FINAL EXAMINATION
60 questions, multiple choice question
WEEKLY TASK : BASIC IMMUNOLOGY

TASK I: CELLS AND TISSUE IN THE IMMUNE SYSTEM

1. Mention tissues and cells involved in the immune system
2. Mention the various classes lymphocytes and what are the function of these
lymphocytes
3. What is the function of bone marrow, thymus and spleen in the immune system?
4. What is APC?? What is the function of dendritic cells?
5. Explain the surface marker of Th17 and Treg

TASK II: INNATE IMUNE AND ADAPTIVE RESPONSE

1. Explain the differences characteristics of natural immune responses (innate) and
acquired immune response (adaptive)
2. Mention the components of innate immunity and adaptive immunity
3. Mention the effector of the humoral and cellular immune system
4. Mention the phase or stages of the immune response
5. How do microbes can escape from the immune system?

TASK III: THE MHC

1. What is the MHC molecules? How many kinds of MHC molecules?
2. What is the role of MHC molecules in the immune system?
3. What is the difference antigen bound by MHC class I and class II?
4. Any kind of cells that express MHC class I and class II molecules?
5. What is the role of MHC molecules in clonal selection?

TASK IV: ANTIGEN CAPTURE AND PRESENTATION TO LYMPHOCYTE

1. What are the differences of antigen recognized by antibody and TCR?
2. What is a three-molecular complex?
3. Explain the costimulatory molecules which is needed to lymphocyte activation
4. What organ is involved in the maturation of T lymphocytes and B lymphocytes?
5. What is the phenomenon of positive selection and negative selection in the process of
maturation of lymphocytes?

TASK V: CYTOKINE
1. What is a cytokine? Explain nomenclature of cytokine
2. Explain the difference between innate and adaptive cytokines
3. What do you know about cytokine receptor?
4. What is a tumor necrosis factor (TNF), what cells produce TNF and explain its
biological action
5. What is interferon?, what cells produce interferon and what is the function of
interferron?
6. Explain about the Septic Shock Syndrome and what kind of cytokines involved?

TASK VI: CELL-MEDIATED IMMUNE RESPONSES

1. Mention the cells involved in CMI
2. What is the characteristic of activated macrophages in CMI?
3. What is the function of effector CD4 T lymphocytes?
 4. What is the function of effector CD8 + T lymphocytes?
5. How do effector T lymphocytes lyse target cells?
6. Explain how the mechanism of intracellular microbes can avoid cellular immune
effector mechanisms

TASK VII: HUMORAL IMMUNE RESPONSES

1. Mention the device of Humoral Immunity
2. Mention the class of antibody and what specific functions of each antibody is!
3. How do effector humoral immunity (antibodies) eliminate the antigen?
4. Explain how the mechanism of extracellular microbes can escape from humoral
effector mechanisms?

TASK VIII: THE SYSTEM COMPLEMENT

1. What is a complement? What is the function of complement system?
2. How many pathways of complement activation? Mentioned each pathway
3. Which parts (fractions) of complement component which serves as
Khemotaxin ?
Opsonin ?
4. How does regulation of the complement system?

TASK IX: IMMUNOLOGIC TOLERANCE

1. What is the immunologic tolerance?
2. What is the mechanism of central tolerance induction in T cells and B cells?
3. What is the mechanism of anergy in T cells in peripheral?
4. What are the causes of breakdown of self tolerance and what are the consequences?

TASK X: REGULATION OF IMMUNE RESPONSES

1. What is the importance of regulation in the immune system?
2. Mention how many kinds of ways the regulation of the immune system
3. How does the mechanism of T-cell apoptosis?
4. How does the mechanism idyotipik regulatory?
5. How does the mechanism of antibody feedback regulation?
6. What is a cytokine regulator?

TASK XI: INFLAMMATION

1. Describe the essence of the inflammatory process at various stages of immune
response (non-specific stage, stage and stage-specific tissue damage)!
2. Cardinal signs of inflammation include tumor, rubor,calor, dolor and function laesa.
Describe the mechanisms associated with each of these markers both in terms of
cellular and humoral!