Molnar 1

CBD Oil Combats Toxic Effects of Chemotherapy Drug

Cisplatin by Reducing Cell Death and Inflammation,
Resulting in Improved Kidney Renal Function

Abstract Summary of Government Compiled Study

By : Ja m e s Al a n Mo l n a r

 A study of whether or not CBD oil reversed chemotherapy-induced cell damage in

the kidneys by decreasing cell death, stress, and inflammation was conducted in
2008. The article was published by The Journal of Pharmacology and Experimental
Therapeutics in March of 2009.
 Mice were given proportional injections of the chemotherapy drug Cisplatin to
mimic the same treatment given to humans suffering from many kinds of different
Cancers.

 Mice were then examined individually from the reactions of the Chemotherapy drug
Cisplatin. Mice marked with histopathological damage and impaired renal function
(kidney damage and general function of the kidneys) were chosen for the CBD Oil
experiment.

 Within 72 hours after initial administration of CBD Oil to infected

chemotherapy-induced mice, the mice started to show reduction of cell death in the
kidneys, reduced inflammation and oxidative/nitrosative stress, and overall
improved renal function of the kidneys.

 Further examination showed CBD Oil began to combat the negative effects of the
Chemotherapy drug Cisplatin within the kidneys in just 12 hours.

 The results suggest CBD Oil represents a new protective strategy in

chemotherapy-induced toxicity of the kidneys. CBD Oil paired with Chemotherapy
combats the negative side-effects of cisplatin which is the main drug used in
chemotherapy treatment.

 “CBD is well tolerated without side effects when chronically administered to

humans and has been reported to exert antioxidant, anti-inflammatory, and
immunomodulatory effects”
 Cannabidiol, known as nonintoxicating CBD Oil, is the largest abstract of the HEMP
plant behind THC. CBD Oil is responsible for providing the medicinal effects users
typically notice after ingesting Marijuana. However, CBD Oil has zero intoxicating
effects and gives non-marijuana users the ability to intake the medicinal effects of
the drug without the intoxicating effects. This provides treatment to a new variety of
patients, specifically those who are inexperienced and deceived by Big Pharma.
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The Title of The Article Reads

 “Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing

Oxidative/Nitrosative Stress, Inflammation, and Cell Death”

Let’s Break It Down Word for Word

-Cannabidiol - Known to general public as CBD Oil, the second largest abstract derived from the
hemp plant behind THC, responsible for producing the known medicinal effects of Marijuana, without
the intoxicating effects of THC.

-Attentuate - to reduce the effect of, or reduce the force of.

-Cisplatin - main drug used in chemotherapy treatment.

-Nephrotoxicity - toxicity in the kidneys, caused by the poisonous effect of the chemotherapy
drug cisplatin.

-Oxidative Stress - an imbalance between free radicals and antioxidants in your body.

-Nitrosative Stress - reactive nitrogen species act together with reactive oxygen species (ROS)
to damage cells.

-Inflammation - a response triggered by damage to living tissues. The inflammatory response is a

human defense mechanism.

-Cell Death - the event of a biological cell ceasing to carry out its functions.

In Layman’s Terms
 “CBD Oil reduces the effect and force of Chemotherapy-induced toxicity of
the kidneys by; reducing cell death, inflammation, the imbalance of free
radicals and antioxidants in the body, and the damaging of cells from
reaction of oxygen and nitrogen species. This concludes in an overall
improvement of renal kidney function giving patients a new positive outlook
on surviving the toxic, damaging effects of the kidneys from the
Chemotherapy drug cisplatin.”
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Original Summary Abstract

Journal of Pharmacology and Experimental Therapeutics

“The platinum compound cisplatin is one of the most potent chemotherapy agents
available to treat various malignancies. Nephrotoxicity is a common complication of
cisplatin chemotherapy, which involves increased oxidative and nitrosative stress,
limiting its clinical use. In this study, we have investigated the effects of a
nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant
effects and has recently been approved for the treatment of inflammation, pain, and
spasticity associated with multiple sclerosis in patients in a mouse model of
cisplatin-induced nephropathy. Cisplatin induced increased expression of
superoxide-generating enzymes RENOX (NOX4) and NOX1, enhanced reactive oxygen
species generation, inducible nitric-oxide synthase expression, nitrotyrosine
formation, apoptosis (caspase-3/7 activity, DNA fragmentation, and terminal
deoxynucleotidyl transferase dUTP nick-end labeling staining), poly(ADP-ribose)
polymerase activity, and inflammation (tumor necrosis factor-α and interleukin-1β) in
the kidneys of mice, associated with marked histopathological damage and impaired
renal function (elevated serum blood urea nitrogen and creatinine levels) 72 h after
the administration of the drug. Treatment of mice with cannabidiol markedly
attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell
death in the kidney, and it improved renal function. Thus, our results suggest that
cannabidiol may represent a promising new protective strategy against
cisplatin-induced nephrotoxicity.”

Source: U.S National Library of Medicine. National Institutes of Health

URL: HTTP://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682269/
URL: https://www.ncbi.nlm.nih.gov/pubmed/19074681