Code No: RR412301

Set No. 1

IV B.Tech I Semester Supplimentary Examinations, February 2008 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. What do you mean by RNA processing? 2. Explain in detail about Tryptophan Operon. 3. Explain kinetics of DNA renaturation. 4. How could you compare genomes with new template method? 5. How could you find genes by EST database? 6. What do you mean by biochipnology. Discuss? 7. What do you mean by metabolomics and how it is categorized? 8. Discuss in detail about intellectual property rights. ⋆⋆⋆⋆⋆ [16] [16] [16] [16] [16] [16] [16] [16]

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Code No: RR412301

Set No. 2

IV B.Tech I Semester Supplimentary Examinations, February 2008 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. What do you mean by RNA processing? [16]

2. Discuss in detail about the Chromosomal Organization of genes and Noncoding DNA. [16] 3. Explain kinetics of DNA renaturation. 4. Discuss in detail about dideoxy method of DNA Sequencing. 5. Write short notes: (a) Protein sequence data (b) Sequence database search. 6. What do you mean by biochipnology. Discuss? [8+8] [16] [16] [16]

7. What do you mean by Pharmacogenomics and explain benefits pharmacogenomics? [16] 8. How could you explain drug design using known receptor structures? ⋆⋆⋆⋆⋆ [16]

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Code No: RR412301

Set No. 3

IV B.Tech I Semester Supplimentary Examinations, February 2008 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Discuss in detail about biodiversity. [16]

2. Explain how chromatin structure plays important role in Eukaryotic gene regulation. [16] 3. Explain kinetics of DNA renaturation. 4. How could you compare genomes clustal W Alignment tool? 5. How do Splice variants can be identified? 6. What do you mean by biochipnology. Discuss? [16] [16] [16] [16]

7. What do you mean by omics and how it is related to metabolomics explain? [16] 8. How could you explain drug design using known receptor structures? ⋆⋆⋆⋆⋆ [16]

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Code No: RR412301

Set No. 4

IV B.Tech I Semester Supplimentary Examinations, February 2008 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Discuss in detail post transcriptional modification of mRNA. [16]

2. Explain how chromatin structure plays important role in Eukaryotic gene regulation. [16] 3. Explain how genome variation can be studied. 4. How could you compare genomes with new template method? 5. Write short notes: (a) Protein sequence data (b) Sequence database search. 6. What do you mean by biochipnology. Discuss? 7. Explain how metabolome gives direct picture of cells activity. 8. What are the molecular basis of drug specificity? ⋆⋆⋆⋆⋆ [8+8] [16] [16] [16] [16] [16]

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