Code No: RR212303 Set No.

1
II B.Tech I Semester Supplimentary Examinations, February 2008
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
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1. What do you mean by bioisosteric groups explain with examples? [10+6]

2. (a) How many types of biomolecules are there?

(b) Discuss the structures of each of the biomolecules. [8+8]

3. (a) Describe the points that Kaiser considered for the design of sumisynthetic
enzyme and explain the choice of suitable cofactor analog.
(b) Describe about the flavopapain preparation by covalent modification. [8+8]

4. Describe various alternations of biocatalyst processing (Biotransformation). [16]

5. Describe different proteins that are in association with metals. [16]

6. How could you correlate the biomodels of copper with its ions. [16]

7. Discuss in detail that the presence of Ni(II) in the cyclodextrin rate of hydrolysis
increases. [16]

8. Explain in detail about Remote functionalization of steroids. [16]

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Code No: RR212303 Set No. 2
II B.Tech I Semester Supplimentary Examinations, February 2008
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) What is and analog?

(b) Explain in detail with examples of molecular modifications. [8+8]

2. (a) What are chemical mutations? Explain any two with suitable examples.
(b) Explain the molecular recognition and drug design. [8+8]

3. Describe the transition state theory in detail with apt examples. [8+8]

4. How are enzymes classified? How do they catalyze the reactions with examples?
[8+8]

5. Write notes on the following on oxygen transport

(a) Bohr effect.

(b) Role of hemoglobin. [8+8]

6. (a) How many oxidation states cobalt has explain?

(b) Explain in detail that coenzyme B12 involved in various reactions. [8+8]

7. (a) What are crown ethers?

(b) Explain in detail about Host-guest relationship. [8+8]

8. Discuss in detail that photo-chemical activation of benzophenone was used to study

intra molecular insertion of benzophenone carboxylic ester of alkanols. [16]

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Code No: RR212303 Set No. 3
II B.Tech I Semester Supplimentary Examinations, February 2008
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) What is an antibiotic?

(b) Explain in detail about antimetabolite with different examples. [8+8]

2. Write short notes [4+4+4+4]

(a) Clasien condensation

(b) Benzoin condensation
(c) Cannizaro reaction
(d) Bayer-viller reaction.

3. Explain molecular recognition with different examples. [12+4]

4. Explain Copperian-Biomodels for photosynthesis and energy transfer. [16]

5. Describe the following mechanisms in hydrolytic enzymes. [8+8]

(a) Peptide hydrolysis.

(b) Catalytic triads.

6. (a) What is a metal ion ?

(b) Explain different biomodels of copper ions. [8+8]

7. Explain the specific cleavage of the cyclic phosphate with a different bis-imadazole
β- cyclodextrin. [16]

8. Explain the two 1,2-methyl migration in lanosterol. [16]

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Code No: RR212303 Set No. 4
II B.Tech I Semester Supplimentary Examinations, February 2008
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) What is meant by molecular recognition? How can you explain this at supra
molecular level? [4+4]
(b) Explain the terms: [8+8]
i. Proximity effect
ii. Molecular adaptation.

2. Write short notes [4+4+4+4]

(a) Clasien condensation

(b) Benzoin condensation
(c) Cannizaro reaction
(d) Bayer-viller reaction.

3. (a) Define mutation.

(b) What is chemical mutation.
(c) Explain transition state analogue of chemical mutation. [5+6+5]

4. (a) What is photosynthesis ? How magnesium involves in the energy transfer?

(b) What is Hill reaction? Explain in detail. [8+8]

5. (a) Explain the functions of metal ions present in the proteins.

(b) Explain the mechanism of carboxypeptidase. [8+8]

6. Explain in detail about the depletion of water molecules through PS I and PSII.
[16]

7. (a) What do you mean by chiral molecule?

(b) Discuss in detail about the synthesis of chiral host molecule. [8+8]

8. Explain in detail about the recent findings in biomimetic polyene cyclizations.[16]

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