adam17

 Official Full Name

 ADAM metallopeptidase domain 17

 Background
 This gene encodes a member of the ADAM (a disintegrin and
metalloprotease domain) family. Members of this family are membrane-
anchored proteins structurally related to snake venom disintegrins, and
have been implicated in a variety of biologic processes involving cell-
cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. The protein encoded by this gene
functions as a tumor necrosis factor-alpha converting enzyme; binds
mitotic arrest deficient 2 protein; and also plays a prominent role in
the activation of the Notch signaling pathway. [provided by RefSeq, Jul
2008]

 Synonyms
 ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18;
CD156B; disintegrin and metalloproteinase domain-containing protein 17;
TNF-alpha convertase; snake venom-like protease; TNF-alpha converting
enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha,
converting enzyme;

 Recombinant Proteins

 Cell & Tissue Lysates

 Assay Kits
Source
Cat.# Product name (Host) Species Tag Price

Adam17- Recombinant Mouse A NS0 Mouse His

+Inquiry
522M Disintegrin And
Metallopeptidase Domain 17,
His-tagged

ADAM17- Recombinant Human ADAM17 Wheat Germ Human GST

+Inquiry
278H Protein, GST-tagged
 Source
Cat.# Product name (Host) Species Tag Price

ADAM17- Recombinant Human ADAM17 Baculovirus- Human N/A

+Inquiry
593H Insect Cells

ADAM17- Recombinant Human ADAM17 E. coli Human His

+Inquiry
7114H protein, His-tagged

Adam17- Recombinant Mouse Adam17 HEK293 Mouse His

+Inquiry
256M protein, His-tagged

ADAM17- Recombinant Rat ADAM17 Mammalian Rat His

+Inquiry
501R Protein Cells

Adam17- Recombinant Rat Adam17 E. coli Rat His/T7

+Inquiry
7115R protein, His & T7-tagged

Adam17- Recombinant Rat Adam17, His HEK293 Rat His

+Inquiry
8788R tagged

ADAM17- Recombinant Chicken ADAM17 Mammalian Chicken His

+Inquiry
1867C Cells

ADAM17- Recombinant Human ADAM Baculovirus- Human His

+Inquiry
592H Metallopeptidase Domain 17, Insect Cells
His-tagged

Involved Pathway

ADAM17 involved in several pathways and played different roles in

them. We selected most pathways ADAM17 participated on our site, such
as Notch signaling pathway, Alzheimers disease, Epithelial cell
signaling in Helicobacter pylori infection, which may be useful for
your reference. Also, other proteins which involved in the same
pathway with ADAM17 were listed below. Creative BioMart supplied
nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
ADAM17A; LNX1; HER9; JAG2B; NOTCH3; HER15.1; MFAP5; RBPJB; MFAP2;
JAG1A
Alzheimers disease
MAPT; BAD; GNAQ; GSK3B; NDUFS5; ATP2A3; COX6C; ATP5E; ATP5O; CALML3
Epithelial cell signaling in Helicobacter pylori infection
MET; TCIRG1; ATP6V1E1; ATP6V0D1; CXCR2; CCL5; ATP6V1A; PLCG2;
ATP6V0C; ATP6V1G1

Protein Function

ADAM17 has several biochemical functions, for example, Notch binding,

PDZ domain binding, SH3 domain binding. Some of the functions are
cooperated with other proteins, some of the functions could acted by
ADAM17 itself. We selected most functions ADAM17 had, and list some
proteins which have the same functions with ADAM17. You can find most
of the proteins on our site.
Function
Related Protein
Function Notch binding
Related Protein C8orf4; NCOR2; NOV; DTX1; JAG1B; JAG1; JAG2B; CHAC1;
NOTCH1; GALNT11
Function PDZ domain binding
Related Protein CADM1; ATP2B4; DTNA; F11R; ACCN3; PARK2; Apba1;
PLEKHA2; ATP2B2; PDZK1
Function SH3 domain binding
Related Protein WIPF3; SGIP1; SHANK1; EPS15; NOXA1; ABI2; PTPN22;
SH3BP1; PARK2; DNM2
Function integrin binding
Related Protein FERMT3; TGFBI; DST; THBS4; PXN; EDIL3; ACTN4; L1CAM;
ICAM5; ADAMTS13
Function interleukin-6 receptor binding
Related Protein ADAM17; IL6; PYCARD; CNTF; ERAP1
Function metalloendopeptidase activity
Related Protein ECEL1; ADAM10B; TLL1; ADAM2; ADAMTS3; HE1B; ADAM20;
UQCRC2B; YBEY; ADAM22
Function metallopeptidase activity
Related Protein C6AST1; MMP23BB; ADAM1B; BMP1A; CNDP1; ERMP1; CPD;
ANPEPA; STAMBP; STAMBPL1
Function protein binding
Related Protein NTRK3; KHDC1B; VCAN; PCBD2; AGO2; TRIM2; BEX1;
CCDC170; NDUFS1; GADD45A
Function zinc ion binding
Related Protein ING2; ADAM2; SNAI1A; ZNF3; TRIM8; GLO1; TRIM65;
LHX8A; EWSR1; OTUD7A

Interacting Protein

ADAM17 has direct interactions with proteins and molecules. Those

interactions were detected by several methods such as yeast two
hybrid, co-IP, pull-down and so on. We selected proteins and
molecules interacted with ADAM17 here. Most of them are supplied by
our site. Hope this information will be useful for your research of
ADAM17.
DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2

ADAM17 Related Articles

Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell
renal cell carcinomas: Implication for patients' prognosis. UROLOGIC
ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014).
Arenaccio, C; Chiozzini, C; et al. Exosomes from Human
Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License
Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and
ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).