vcam1

 Official Full Name

 vascular cell adhesion molecule 1

 Background
 Human Vascular Cell Adhesion Molecule-1 is a 100 - 110 kDa, 715 amino
acid type I transmembrane glycoprotein typically characterized by the
presence of seven C2-type immunoglobulin domains. Its extracellular
region is 674 aa in length, followed by a 22 aa transmembrane segment
and a 19 aa cytoplasmic tail. In the extracellular region, there are
multiple N-linked glycosylation sites, and each C2 domain is closed by
a disulfide bridge. There is considerable interspecies VCAM-1 homology,
with mouse and rat VCAM-1 showing approximately 75% aa identity to
human VCAM-1. Notably, the short 19 aa cytoplasmic tail is absolutely
conserved, mouse to human to rat. Cells expressing mouse VCAM-1 bind
both mouse and human leukocytes, and this reflects their high degree of
aa identity. A number of variants of VCAM-1 are known to occur, all of
which are likely the result of alternate gene splicing. In particular,
a human six Ig domain molecule is known, and in rabbits, an eight Ig
domain form has been identified. There is also a three-C2 domain, 43
kDa GPI-linked form of VCAM-1. Although it binds known VCAM-1 ligands,
its function is unclear. Cells known to express VCAM-1 include neurons,
endothelial cells, smooth muscle cells, fibroblasts and macrophages.
Soluble VCAM-1 has been identified in culture supernates, blood, and
cerebrospinal fluid. In vitro, basal levels of VCAM-1 shedding by
unstimulated NIH3T3 cells appear to partially require metalloproteinase
activity, while PMA-induced shedding is dependent upon the proteolytic
activity of TACE/ADAM17.
Functionally, VCAM-1 binds to both 4 1 and 4 7 integrins. These
integrins are expressed on a variety of cells, with VLA-4 found on all
leukocytes with the exception of neutrophils. Because of this, VCAM-
1/VCAM-1 ligand interactions are undoubtedly key events in the rate and
timing of leukocyte extravasation. Other roles proposed for VCAM-1
include the regulation of osteoclastogenesis via a cell-to-cell contact
mechanism and the induction of sickle cell adherence to vascular
endothelial cells during hypoxemia.
The Human sVCAM-1 Immunoassay is a 2 hour solid-phase ELISA designed to
measure human sVCAM-1 in cell culture supernates, serum, and plasma. It
contains CHO cell-expressed recombinant human sVCAM-1 and has been
shown to accurately quantitate the recombinant factor. Results obtained
using natural human sVCAM-1 showed linear curves that were parallel to
the standard curves obtained using the kit standards. These results
 indicate that the Human sVCAM-1 immunoassay kit can be used to
determine relative mass values for naturally occurring sVCAM-1.

 Synonyms
 VCAM1; vascular cell adhesion molecule 1; INCAM-100; Vascular cell
adhesion protein 1 precursor; CD-10^6 antigen; CD10^6; DKFZp779G2333;
MGC99561; CD10^6 antigen; OTTHUMP00000012650; OTTHUMP00000012651;
L1CAM; V-CAM 1; CD106; Vcam-1

 Recombinant Proteins

 Cell & Tissue Lysates

Source
Cat.# Product name (Host) Species Tag Price

VCAM1- Recombinant Mouse CHO Cells Mouse MIgG2a

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1793MA VCAM1 protein, Fc
MIgG2a Fc-tagged,
APC labeled

VCAM1- Recombinant Mouse CHO Cells Mouse MIgG2a

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1793MP VCAM1 protein, Fc
MIgG2a Fc-tagged,
R-PE labeled

VCAM1- Recombinant Human CHO Cells Human HIgG1

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1794MA VCAM1 protein, Fc
HIgG1 Fc-tagged,
APC labeled

VCAM1- Recombinant Human CHO Cells Human HIgG1

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1794MP VCAM1 protein, Fc
HIgG1 Fc-tagged, R-
PE labeled

Vcam1- Recombinant Mouse HEK293 Mouse FC/His

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2313MA Vcam1 protein, Fc-
 Source
Cat.# Product name (Host) Species Tag Price

His-tagged, APC
labeled

Vcam1- Recombinant Mouse HEK293 Mouse FC/His

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2313MP Vcam1 protein, Fc-
His-tagged, R-PE
labeled

VCAM1- Recombinant Human HEK293 Human Fc

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71HA VCAM1 protein, Fc-
tagged, APC labeled

VCAM1- Recombinant Human HEK293 Human Fc

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71HP VCAM1 protein, Fc-
tagged, R-PE
labeled

VCAM1- Recombinant Human HEK293 Human MYC/DDK

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117H VCAM1 Protein,
MYC/DDK-tagged

VCAM1- Recombinant Human NS0 Human His

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170H VCAM1 protein, His-
tagged

VCAM1- Recombinant Human CHO Human Fc

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1794M VCAM1, HIgG1 Fc-
tagged

VCAM1- Recombinant Human E. coli Human T7

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179H VCAM1 protein, T7-
tagged
 Source
Cat.# Product name (Host) Species Tag Price

VCAM1- Recombinant Human HEK293 Human

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191H VCAM1 Protein

VCAM1- Recombinant Human HEK293 Human His

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2325H VCAM1, His tagged

VCAM1- Recombinant Human E. coli Human His

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31199TH VCAM1, His-tagged

VCAM1- Recombinant Human HEK293 Human His

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3142H VCAM1, His tagged

VCAM1- Recombinant Human E. coli Human His

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6796H Vascular Cell
Adhesion Molecule
1, His-tagged

VCAM1- Recombinant Human Insect Human His

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68H VCAM1 Protein, His- cells
tagged, Bioactivity
Validated

VCAM1- Recombinant Human HEK293 Human Fc

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71H VCAM1, Fc tagged

Vcam1- Recombinant Mouse NS0 Mouse N/A

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1784M Vascular Cell
Adhesion Molecule 1

VCAM1- Recombinant Mouse CHO Mouse Fc

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1793M VCAM1, MIgG2a Fc-
tagged
 Source
Cat.# Product name (Host) Species Tag Price

Vcam1- Recombinant Mouse Insect Mouse His

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188M Vcam1 protein, His- cell
tagged

Vcam1- Recombinant Mouse HEK293 Mouse FC/His

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2313M Vcam1, Fc-His
tagged

Vcam1- Recombinant Mouse E. coli Mouse His

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2771M Vcam1 protein, His-
tagged

Vcam1- Recombinant Mouse E. coli Mouse His

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2772M Vcam1 protein, His-
tagged

Vcam1- Recombinant Mouse HEK293 Mouse His

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4012M Vcam1, His tagged

Vcam1- Recombinant Mouse HEK293 Mouse His

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4013M Vcam1, His-tagged

Vcam1- Recombinant Mouse NSO cells Mouse Fc

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491M Vcam1, Fc Chimera Chimera

Vcam1- Recombinant Rat E. coli Rat His/T7

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2773R Vcam1 protein, His
& T7-tagged

VCAM1- Recombinant Rat Mammalian Rat His

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6505R VCAM1 Protein Cells
 Source
Cat.# Product name (Host) Species Tag Price

VCAM1- Recombinant Rhesus HEK293 Rhesus

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1534R Monkey VCAM1 monkey
Protein

VCAM1- Recombinant Rhesus HEK293 Rhesus hIgG1

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1535R Monkey VCAM1 monkey
Protein, hIgG1-
tagged

VCAM1- Recombinant Rhesus HEK293 Rhesus hIgG4

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1536R Monkey VCAM1 monkey
Protein, hIgG4-
tagged

VCAM1- Recombinant Rhesus E. coli Rhesus His/T7

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2775R monkey VCAM1 monkey
protein, His & T7-
tagged

VCAM1- Recombinant Dog E. coli Dog His

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2770D VCAM1 protein, His-
tagged

VCAM1- Recombinant Rabbit E. coli Rabbit His/S

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2774R VCAM1 protein, His
& S-tagged

VCAM1- Recombinant Mammalian Zebrafish His

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5452Z Zebrafish VCAM1 Cells

VCAM1- Recombinant Human NS0 Human N/A

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1695H Vascular Cell
Adhesion Molecule 1
Involved Pathway

VCAM1 involved in several pathways and played different roles in

them. We selected most pathways VCAM1 participated on our site, such
as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), TNF
signaling pathway, which may be useful for your reference. Also,
other proteins which involved in the same pathway with VCAM1 were
listed below. Creative BioMart supplied nearly all the proteins
listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
CCL13; GM1987; BLNK; BCL2; ICAM1; GM13304; PLCG1; PLAU; SYK; LTB
Cell adhesion molecules (CAMs)
SELL; CLDN18; NEGR1; HLA-DRB4; CADM1A; JAM2A; PVRL3; PVRL1; CLDNJ;
SDC1
TNF signaling pathway
CASP7; MAP3K5; PIK3CG; NFKBIA; LTA; MAPK11; FAS; CXCL10; TAB2; MAP2K6
Leukocyte transendothelial migration
ICAM1; VASP; CLDN2; VAV2; MYLPF; RAC1; ACTN1; CLDN20; MYL2; NCF2
African trypanosomiasis
IFNG; SELE; HBB; F2RL1; FAS; HPR; IL18; HBA2; PRKCB; HBB-B1
Malaria
CD81; IL-8; MET; ITGAL; KLRK1; KLRC4-KLRK1; IL12A; Ccl12; CCL2;
CD40LG
HTLV-I infection
FZD9; PTTG2; XIAP; LTA; VDAC1; POLE4; CDC16; VDAC2; NFATC2; LCK

Protein Function

VCAM1 has several biochemical functions, for example, cell adhesion

molecule binding, integrin binding, primary amine oxidase activity.
Some of the functions are cooperated with other proteins, some of the
functions could acted by VCAM1 itself. We selected most functions
VCAM1 had, and list some proteins which have the same functions with
VCAM1. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein PVRL1A; ITGA4; JUP; CXADR; ITGB1; PVRL3; NRXN2;
NLGN1; PKP3; NLGN3
Function integrin binding
Related Protein PTPN2; FN1A; GFAP; LAMB2; ITGA5; ADAM17; WISP1;
FBLN1; ICAM2; CALR
Function primary amine oxidase activity
Related Protein ABP1; MAOB; AOC2; AOC1; AOC3; MAOA; VCAM1

Interacting Protein

VCAM1 has direct interactions with proteins and molecules. Those

interactions were detected by several methods such as yeast two
hybrid, co-IP, pull-down and so on. We selected proteins and
molecules interacted with VCAM1 here. Most of them are supplied by
our site. Hope this information will be useful for your research of
VCAM1.
ITGB1; ZYX; TLN1; PSMD11

VCAM1 Related Articles

Almeda, D; Wang, BR; et al. Minimizing antibody surface density on

liposomes while sustaining cytokine-activated EC targeting.
BIOMATERIALS 41:37-44(2015).
Marschall, AL; Single, FN; et al. Functional knock down of VCAM1 in
mice mediated by endoplasmatic reticulum retained intrabodies. MABS
6:1394-1401(2014).