Académique Documents
Professionnel Documents
Culture Documents
Balintfy, J. (2019, February 28). Data sharing uncovers five new risk genes for Alzheimer’s
/datasharing-uncovers-five-new-risk-genes-alzheimers-disease
attempts to identify risk genes that can be used to identify Alzheimer’s development.
development of the disease, and by finding these genes, drugs can be made to target their
development. This genomic research is critical to accurate drug development, and will
hopefully deduce the amount of time it takes to develop a cure because there is less guess
and check occurring with the drug development, when the researchers know what gene
they are dealing with. This article is beneficial as it is a very modern example of how
genomic research is actively being used to develop drugs for incurable diseases.
Beck, S., & Paul, D. S. (2014, October 1). Advances in epigenome-wide association studies for
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This issue details some of the current trends in molecular medicine, specifically
genetic material of a cell. While the issue does not cover how epigenetic modifications
work or how they are specifically studied, it does detail a couple of examples in recent
years of how epigenetic modifications have been used in research. The primary type it
covers is DNA methylation, adding a methyl group to DNA to not alter the structure, but
change the function of the DNA. The information found in this issue is valuable because
it explains various cases where epigenetic research has made progress. Some of these
cases have been in rheumatoid arthritis, type I diabetes, and multiple sclerosis. The last
paragraph of the issue is a short opinion on EWAS, that introduces a little explanation of
Cancer Genomics Research. (2018, November 20). National Cancer Institute. Retrieved from
https://www.cancer.gov/research/areas/genomics
This article presents valuable information about the National Cancer Institute and how it
is currently using genomic research to learn more about cancer. Specifically, genomic
research is showing that under specific cancers, there are many more subset, which could
better be treated in specific ways rather than coming up with treatments for cancer in
general. The idea of specificity is becoming a common theme, which suggests that
This article says that genomic cancer research will “increasingly be integrated with
patients’ medical histories and clinical data … to develop more tailored approaches to
cancer diagnosis and treatment.” The information presented through this article links
together genomic research with the emerging emphasis on precision medicine and how
Collins, F. S., & Varmus, H. (2015, February 26). A New Initiative on Precision Medicine. The
/NEJMp1500523
President Obama released in his 2015 State of the Union address that he would begin a
new initiative to launch Precision medicine to hopefully come closer to finding cures and
treatments for diseases such as cancer and diabetes. The article explains that precision
medicine is a method of research that focuses on “prevention and treatment strategies that
take individual variability into account,” which has already been used for years in
methods such as blood typing. However, now, precision medicine is used in a new way to
research for diseases. The most prominent facet where precision medicine is used is in
precision oncology, which has made many breakthroughs in recent years, but needs more
support and creative ingenuity to progress further. This article provides a good outline for
how precision medicine has been pioneering new disease research methods, and clearly
describes the current benefits that precision medicine will provided the medical field if it
was given a larger focus, which is what Obama was attempting to do with this initiative.
Current News Releases. (2018, September 24). National Human Genome Research Institute.
This article has a timeline from January 2018 to October 2018 that detailed the National
Human Genome Research institute’s news releases throughout the time period. Most of
the news surrounds large releases of new studies or awards being given for impressive
research work, but interestingly, the two most current posts to this site (September and
October) mention precision medicine being used for one of the first times by the NIH
Clinical Genome Resource program and epidemiology being used to recognize racial
validates the conclusions that claim precision medicine and epidemiology are some of the
Guhr et al. (2018, July 19). Recent Trends in Research with Human Pluripotent Stem Cells:
Impact of Research and Use of Cell lines in Experimental Research and Clinical Trials.
Stem Cell Reports, 11(2), 485-496. Retrieved from https://www.ncbi.nlm.nih.gov/pmc
/articles/PMC6092712/
This article is a review of the studies on Human Pluripotent Stem Cells, an analysis on
how that research is affecting experiments and clinical trials. It began with the history of
hPSC research and the development of hiPSCs, then began the analysis of global studies
using hPSCs and hiPSCs, and ended with how that is affecting research. This article does
not give specific examples of how these cells are specifically helping to cure diseases;
however, it explains the methods researchers apply when using these cells, which will be
helpful when finding studies involving these cells. Additionally, the article briefly
addresses the ethical dilemma of using these cells, and how that is contributing to a steep
increase in hiPSC usage, while there is only a slow increase of hPSC usage in studies.
Rizzi, L., Rosset, I., & Roriz-Cruz, M. (2014, June 25). Global Epidemiology of Dementia:
from https://www.hindawi.com/journals/bmri/2014/908915/cta/
This articles gives a clear description of how epidemiology is being used to track
Alzheimer’s across the world in two specific capacities: through a descriptive point and
analytical point. It then proceeds to give specific studies large-scale studies and case
studies across the globe that report on Alzheimer and Dementia prevalence. Specifically,
there’s and analysis of studies from Europe, North America, Latin America, Asia, China,
Japan, Africa, and the Middle East. This is information easily describes how
epidemiological studies can be put into effect to help find treatments or cures. Because
this article goes through and details epidemiology very well, it presents a good baseline
level of understanding of epidemiology, which can be applied to other articles that
reference epidemiology.
Rohrid et al. (2009, April 10). Types of Study in Medical Research. National Institute of
This article discussed the differences between types of medical research, which are basic
medical research, clinical research, and epidemiological research. Basic medical research
effects of drugs, and epidemiological research investigates the distribution and historical
care.
Schattner, E. (2017, December 31). 7 Key Cancer Trends for 2018. Forbes. Retrieved from
https://www.forbes.com/sites/elaineschattner/2017/12/31/7-key-cancer-trends-for
2018/#b213a662d0e7
This article compiled the primary trends in cancer research from 2017. It briefly describes
each of the ten cancer research trends, which are, less chemotherapy, more prescription of
novel anti-cancer agents, concern over cancer drug costs, focus on diagnostics, quality
and payment for genetic cancer tests, tumor-agnostic prescription of cancer medications,
patient-reported outcomes, and artificial intelligence. While the article does not have a
quality descriptions or research on each of these topics, it is a good starting place to base
further research on incurable disease research efforts off of. The research innovations are
very modern, and will provide key words to use for further research.
What are the next steps in genomic research?. (2019, March 19). U.S. National Library of
This article is a review of the current route genomic research is headed towards and some
of the progress it made. It does a good job explaining the purpose of genomic research,
and how it will be used in application. For example, one of its purposes is
These are common genetic variations in DNA, that serve as biological markers, which
help scientists associate particular genes with diseases. This article overall has good
descriptions of the new methods used in genomic research, which will serve as a good