I.

Molecular Biochemistry

DNA Structure Nucleotides, purines, pyrimidines, histones, DNA

methylation, histone acetylation (13min)

Purine Metabolism PRPP, IMP, purine salvage, 6-MP, gout, Lesch-

Nyhan syndrome (18min) UPDATED 7-20-2016

Pyrimidine Metabolism Carbamoyl phosphate, orotic aciduria, folate, B12,

5-FU, methotrexate (22min) UPDATED 6-20-2016

II. Metabolism

Glucose Carbohydrate structure, glucose metabolism

overview, glucose absorption and transport (8min)

Glycolysis Glycolysis pathway, enzymes, reactions and

regulation (31min) UPDATED 6-20-2016

Gluconeogenesis Gluconeogenesis pathway, enzymes, reactions, and

regulation (17min)

Glycogen Glycogen structure, synthesis, breakdown, and

regulation; Glycogen storage diseases (21min)

HMP Shunt Reactions, enzymes, NADPH, Glucose-6-

Phosphate Dehydrogenase (G6PD) deficiency
(14min)

Fructose and Galactose Fructose and galactose metabolism; hereditary

fructose intolerance, galactosemia (13min)

Pyruvate Dehydrogenase Pyruvate dehydrogenase complex; Co-factors;

Pyruvate dehydrogenase complex deficiency
(17min)

TCA Cycle TCA cycle reactions, inhibitors, and activators

(13min)
 Electron Transport Chain Complexes I, II, III, and IV; Coenzyme Q;
Cytochrome C; Carbon Monoxide; Cyanide; Brown
fat (20min)

Fatty Acids Fatty acid structure; Fatty acid synthesis; Beta

oxidation; Carnitine deficiency (26min)

Ketone Bodies Ketone body synthesis; ketolysis; ketones in

diabetes/alcoholism (8min)

Ethanol Metabolism Alcohol and aldehyde dehydrogenase;

Hypoglycemia and lactic acidosis in alcoholism;
Disulfiram (18min)

Exercise and Starvation Creatine; Aerobic and anaerobic exercise;

Metabolism during fasting and starvation (22min)

Inborn Errors of Metabolism Recognition of newborns with metabolic disorders

(21min) NEW 12-6-2016

III. Amino Acids

Amino Acids Amino acid structure; pKa values; basic and acidic
amino acids; glucogenic/ketogenic (17min)

Phenylalanine and Tyrosine Phenylketonuria, Alkaptonuria, Albinism,

Catecholamine synthesis; Monoamine oxidase;
COMT (25min)

Other Amino Acids Tryptophan; Branched chain amino acids; Maple

syrup urine disease; Homocystinuria (19min)

Ammonia Alanine cycle, Hyperammonemia, Urea cycle,

Ornithine transcarbamylase deficiency (17min)

IV. Vitamins

B Vitamins Vitamins B1, B2, B3, B5, B6, and B7 (23min)

UPDATED 6-20-2016
 B12 and Folate Structure and function of vitamin B12 and Folate;
Folate deficiency; Pernicious anemia (20min)

Other Vitamins Structure, function, and deficiency of vitamins A,

C, D, E and K; Zinc (32min)

V. Lipids

Lipid Metabolism Chylomicrons, VLDL, LDL, HDL,

Abetalipoproteinemia (20min) UPDATED 7-25-
2016

Hyperlipidemia Primary and secondary hyperlipidemia; Familial

hyperlipidemias (10min)

Lipid Drugs Statins, Ezetimibe, Niacin, Fibrates, Omega 3 fatty

acids (22min)

VI. Other Topics

Lysosomal Storage Diseases Gaucher's, Fabry's, Krabbe's, Tay Sachs, Niemann-

Pick, Hurler's, Hunter's, I-cell disease (31min)