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methods
Presented by
Dr. A. Suneetha
Dept. of Pharm. Analysis
Hindu College of Pharmacy
Calibration
A set of operations, performed in accordance with a definite
procedure, that compares the measurements performed by an
instrument to those made by a more accurate instrument or a
standard for the purpose of detecting co-relate and reporting,
by adjustment errors met in the instrument tested.
Purpose of Calibration
To ensure readings from an instrument are consistent with other
instruments and to determine the accuracy of the instrument i.e.
that it can be trusted for its observed/displayed measured value.
CALIBRATION OF INSTRUMENTS:
Measurement of Accuracy
Establishment the relation of an instruments accuracy to the
international standards.
Instrument to be
Instrument Output
Input (whole calibrated
measuring range)
Ensure the
Environmental calibration is done
Conditions Standard
Instrument under the specified
(Modifying Inputs) environmental
conditions
Calibrate with internal 20g weight for analytical balance and with
100mg as microbalance.
Analytical balance : Use 20gm weight there should be no variation
in the first four places to the right of decimal .
Micro balance : use 100 mg weight there should be no variation in the
first three places to the right of decimal.
Calibration:
Calibration must be performed using a certified polystyrene
film.
Manufacturer Serial
Type of Instrument: Instrument Model:
Number:
Company Serial Company’s Part
Date Introduced:
Number: Number:
Measurement Limits: Location: Calibration frequency:
Person Responsible for
Name: Signature:
Calibration
Instructions for use:
Calibration Record
Calibration Date Calibration Results Calibrated by
REFERANCE:
• Indian Pharmacopoeia, Published by the Controller
of publication,Delhi,Vol 2 – 1996.
• WWW.WIKIPEDIA
THANK Q