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  • Devia Afiani I1021161010

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    DEVIA
    15 vues5 pages
    The document contains the results of a pharmacokinetic analysis for two different drug doses: 50 mg and 100 mg. It includes calculations for half-life, elimination rate constant, plasma concentration over time, volume of distribution, and determining the initial drug concentration based on measured plasma concentrations at later times. The analysis shows that for a 50 mg dose, half-life is 0.6847 hours, volume of distribution is 19.37 L, and initial concentration is 2.58 μg/mL. For a 100 mg dose, half-life is 0.6198 hours, volume of distribution is 21.308 L, and initial concentration is 4.693 μg/mL.

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    Devia Afiani i1021161010

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    The document contains the results of a pharmacokinetic analysis for two different drug doses: 50 mg and 100 mg. It includes calculations for half-life, elimination rate constant, plasma concentration over time, volume of distribution, and determining the initial drug concentration based on measured plasma concentrations at later times. The analysis shows that for a 50 mg dose, half-life is 0.6847 hours, volume of distribution is 19.37 L, and initial concentration is 2.58 μg/mL. For a 100 mg dose, half-life is 0.6198 hours, volume of distribution is 21.308 L, and initial concentration is 4.693 μg/mL.

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    15 vues5 pages

    Devia Afiani I1021161010

    Transféré par

    DEVIA
    The document contains the results of a pharmacokinetic analysis for two different drug doses: 50 mg and 100 mg. It includes calculations for half-life, elimination rate constant, plasma concentration over time, volume of distribution, and determining the initial drug concentration based on measured plasma concentrations at later times. The analysis shows that for a 50 mg dose, half-life is 0.6847 hours, volume of distribution is 19.37 L, and initial concentration is 2.58 μg/mL. For a 100 mg dose, half-life is 0.6198 hours, volume of distribution is 21.308 L, and initial concentration is 4.693 μg/mL.

    Droits d'auteur :

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    sur 5

    Nama : Devia Afiani

    Nim : I1021161010

    1.

    Gambar grafik pada kertas semilog sebagai berikut :

    Berdasarkan hasil regresi linear, diperoleh nilai :

    a = 4,537

    b = -0,5576 = k

    c = -0,99954

    0,693
    a. T1/2 = 𝑘
    0,693
    T1/2 = 0,5576
    T1/2 = 1,2428 jam

    𝑙𝑛𝑐2−𝑙𝑛𝑐1
    b. K= 𝑡2−𝑡1

    ln 30−ln 54
    K= 2,0−1,0

    3,4011−3,98898
    K= 1,0

    −0,5576
    K= = -0,5576
    1,0

    c. Ct = C0 . e-kt
    68 = C0 . e-0,5576 . 0,5
    68
    C0 = 0,75669

    C0 = 89,865 µg/ml

    d. Vd = Div
    𝐶𝑜
    250.000 µg
    Vd = 89,865 µ𝑔/𝑚𝑙
    Vd = 2781,95 ml = 2,781 L

    e. C75 = C0 . e-kt
    C75 = 89,865 . e-kt
    C75 = 89,865 . e-0,557 . 75
    C75 = 89,865 . e-41,775
    C75 = 89,865 . 7,2 x 10-19
    C75 = 6,4705 X 10-17 µg/mL
    Dosis
    C0 = 𝑉𝑑
    175 mg
    C0 = 2781,95 mL
    C0 = 0,062905 mg/mL
    C0 = 62, 905 µg/mL

    Cp = C0 . e-kt
    C75 = 62,905 . e-0,557 . 1,25
    C75 = 62,905 . e-0,6962
    C75 = 31,356 µg/mL

    Dosis
    f. C0 = Vd
    275000
    C0 = 2781,95
    C0 = 98,851 µg/mL

    Cp = C0 . e-kt
    20 = 98,851 . e-0,5576 . t
    0,2023 = e-0,5576 . t
    -1,598 = -0,5576 . t
    t = 2,865 jam

    2.
    0,693
    a. Dosis 50 mg : t½ = 𝑘
    0,693
    = 1,012
    = 0.6847 jam
    0,693
    Dosis 100 mg : t½ = 𝑘
    0,693
    = 1,118= 0,6198 jam

    0,5
    𝑙𝑛0,3
    b. Dosis 50 mg : k = 2−1,5
    ln 1,666
    = 2,0−1,5
    0,5104
    = 0,5
    = 1,0208 jam-1
    1,4
    𝑙𝑛0,8
    Dosis 100 mg : k = 1,5−1
    0.559
    = 0,5

    = 1,118 jam-1

    c. Dosis 50 mg : Cp = C0 . e –kt
    2 = C0 . e –1,0208 . 025

    2 = C0 . 0,775
    2
    C0 = 0,775

    = 2.58 µg mL-1

    Dosis 100 mg : Cp = C0 . e –k.t

    2,6 = C0 . e –1,118 . 0,25

    2,6 = C0 . 0,5539
    2,6
    C0 = 0,5539

    C0 = 4,693 µg mL-1
    𝐷𝑜𝑠𝑖𝑠
    d. Dosis 50 mg : V = (𝐶𝑝)₀
    50 𝑚𝑔
    V = 2,58 µg mL−1 = 19,37 𝐿

    𝐷𝑜𝑠𝑖𝑠
    Dosis 100 mg : V = (𝐶𝑝)₀

    100 𝑚𝑔
    V = 4,693 µg mL−1 = 21,308 𝐿

    e.

    f. Dik : K = 1.118 jam-1

    t = 2,5 jam

    Dit : C0 ?

    Cp = C0 . e –k.t

    225 = C0 . e –1,118 . 2.5


    225
    C0 = 0,8173

    C0 = 275,3 mg

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