Académique Documents
Professionnel Documents
Culture Documents
+
NH3
RCOOAg
+ RCOOH
Br2 +
+ CCl4 R’OH
CH3COOH
+
PhCOOH
CH3COOH RCOOH
+ +
CH3COCl CH2N2
CH3COOH
+
CH2=C=O
MADE BY –
RAHUL BATRA
X II – B
12224
TO FIND OUT THE PERCENTAGE
COMPOSITION OF ASPIRIN IN
IN DAILY LIFE
I EXPRESS MY SINCERE THANKS AND DEEP THANKS OF
GRATITUDE TO RESPECTED MS.VANIKA ARORA MY
CHEMISTRY TEACHER, ADARSH PUBLIC SCHOOL, FOR HER
PRECIOUS GUIDANCE AND CONTINUOUS ENCOURAGEMENT
THROUGHOUT THE INVESTIGATION OF THE PROJECT AND
TO MY LAB ASSISTANT FOR THEIR HELP , WITHOUT WHICH
COMPLETION OF THIS PROJECT COULD NOT HAVE BEEN
POSSIBLE.
RAHUL BATRA
XII-B
THIS IS TO CERTIFY THAT THE PROJECT “TO FIND THE %
COMPOSITION OF ASPIRIN IN SOME OF THE MEDICINES
USED IN DAILY LIFE” HAS BEEN COMPLETED BY RAHUL
BATRA OF CLASS XII-B OF MY SCHOOL DURING THE SESSION
OF 2008-2009 UNDER MY SUPERVISION
MS.VANIKA ARORA
CHEMSTRY TEACHER
ADARSH PUBLIC SCHOOL
INTRODUCTION
THEORY
APPARATUS
MATERIAL REQUIRED
PROCEDURE
CALCULATION AND OBSERVATION
RESULTS
PRECAUTIONS
BIBILIOGRAPHY
There are two kind of pain killer namely narcotics like morphine. Also the
antipyretic drugs have direct action on the diseased part of the body.
Acetyl salicyclic acid is one such non-narcotic, anti-pyretic and is still
used for many ailments. Aspirin can be obtained in the form of tablets,
powder or combined with other drugs.
* Relieving aches, pains and fever associated with cold and flu.
SIDE EFFECTS
Medicines and their possible side effects can affect individual people in
different ways. The following are some of the side effects that are known
to be associated with this medicine. Because a side effect is stated here,it
does not mean that all people using this medicines will experience that or
any side effect .
* Indigestion(dyspepsia)
* Nausea
* Stomach or intestinal discomfort
* Sensation of ringing, or other noise in the ears(tinnitus)
* Worsening of asthma
* Allergic reactions such as skin rash, swelling of the lips, tongue and
throat (angioedema) or narrowing of the aiways(bronchospasm)
*Increased bleeding time
* Ulceratin or bleeding of the stomach or intestines
CHEMICAL CHARACTERISTICS OF ASPIRIN
FORMULA C9H8O4
MOLECULAR WEIGHT 180.16
MELTING POINT 135OC
Stable in dry air but hydrolysis to salicyclic acid and acetic acid in moist
air
pK = 3.49(250C)
One gram dissolves in 300ml water at room temperature
CHEMISTRY OF ASPIRIN
Aspirin , also known as 'acetylsalicyclic acid' .
The chemical structure of aspirin:
COOH
OCOCH3
ASPIRIN
END POINT
The end point in the titration after the completion of the reaction and marked some
colour change.
MOLARITY
The number of moles of solute per litre of solution.
Burette
Pipette
Conical Flask
Clamp stand
Chemical Balance
Weight Box
Measuring Flask
The end points of the reaction has to be noted down crefully.
titration.
Oxalic Acid
Distilled Water
Phenolphthalein
www.bmj.com
www.springerlink.com
www.odadas.state.oh.us
www.wipo.int
0.4 GM of Sodium Hydroxide was weight in a chemical balance and
dissolved in 100cc of distilled water to get 0.1M solution is deliquescent ,
the solution obtained above is not exactly of molarity 0.1M . Therefore this
solution was titrated against standard Oxalic acid of 0.05M. Now standard
Oxalic acid was pipette out in a conical flask and 4-5 drops of
phenolphthalein were added as the indicator . Then after taking the initial
reading of NaOH in the burette , it was let out drop by drop. The NaOH is
added till the solution in the conical flask changes from colourless to pink.
The colour change should be permanent . This was the end point of the
reaction . The same steps were repeated until three concordant readings were
obtained .
Then the tablets are taken and made into power, around three tablets of each
type were powdered and then dissolved in 100cc of water to get solution.
Now the standard NaOH solution was filled in the burette and 10cc of the
prepared solu tion of the medicine was taken (with a pipette) and put in a
clean conical flask 1-2 drops of phenolphthalein and indicator. Then after
taking the initial reading of sodium hydroxide in the burette, it was let out
drop by drop. The phenolphthalein turns pink in a basic medium . So the
NaOH is added until there is a colour change of the solution in the conical
flask from colourless to pink . The colour change indicated the end point of
the reaction (this is the point when all acid was consumed and there was one
extra drop of the base to make the colour of the phenolphthalein pink ).
The same steps were repeated until three concordant reading (of the column
of Sodium Hydroxide solution) was obtained . The first reading was done
quickly and rough result of the volume of, Sodium Hydroxide to be used
was obtained . This makes the following reading easier and faster to take.
Standardization of NaOH solution
Solution in Burette - NaOH
Solution in Pipette - Oxalic Acid
Molarity of Oxalic Acid - 0.05
Volume of Oxalic Acid - 10 mL
End Point - colourless to pink
Indicator - Phenolphthalein
1 10 10 20.2 10.2
2 10 8 18 10.0
3 10 11 21 10.0
4 10 2 12 10.0
Indicator Phenolphthalein
1 10 11 15.1 4.1
2 10 7 11 4
3 10 8 12 4
4 10 6 10 4
Z1 = 1 Z2 = 2
M1 = 0.1M M2 = ?
V1 = 4 ml V1 = 10ml
Z1 M1 V1 = Z2 M2 V2
= 1 x 0.1 x 4 = 1 x M2 x 10
# M2 = 0.040 moles/litre
= 50%
Weight of 3 Tablets of Anacin 1.20 gm
( dissolved ml of water )
Indicator Phenolphthalein
1 10 9 13.1 4.1
2 10 6 10.3 4.3
3 10 7 11.3 4.3
4 10 8 12.3 4.3
Z1 = 1 Z2 = 1
M1 = 0.1 M M2 = ?
V1 = 4.3 ml V1 = 10 ml
Z1 M1 V1 = Z2 M2 V2
=1 x 0.1 x 4.3= 1 x M2 x 10
Indicator Phenolphthalein
Z1 = 1 Z2 = 1
M1 = 0.1 M M2 = ?
V1 = 4 ml V1 = 10 ml
Z1 M1 V1 = Z2 M2 V2
= 1 x 0.1 x 4 = 1 x M2 x 10