STATISTICAL STUDY ON FACTORS

AFFECTING THE MEASURE OF GLOBAL

BRAIN ATROPHY ON MRI SCAN

Project report submitted to

MAR ATHANASIUS COLLEGE KOTHAMANGALAM

(AUTONOMOUS)

In partial fulfilment of the requirements for the degree of

MASTER OF SCIENCE

IN

STATISTICS

By

SIJI ELSA PAUL

Reg No: 162745

DEPARTMENT OF STATISTICS

MAR ATHANASIUS COLLEGE, KOTHAMANGALAM

(AUTONOMOUS)

JUNE 2018
 Department of Statistics
Mar Athanasius College, Kothamangalam
Kerala, Pin: 686691

CERTIFICATE

I, here by certify that this project on “STATISTICAL STUDY ON

FACTORS AFFECTING THE MEASURE OF GLOBAL BRAIN ATROPHY ON MRI SCAN”

is a bonafide record of work done by Ms. SIJI ELSA PAUL carried out by, here in the

‘Department of Statistics, Mar Athanasius College, Kothamangalam’ under my

supervision, in partial fulfilment of the requirements for the Degree of Master of

Science in Statistics of Mar Athanasius College, Kothamangalam.

Mrs. Sari Thomas Mrs. Sari Thomas

(Head of the Department) (Supervising Teacher)
 ACKNOWLEDGEMENT

I would like to express my profound gratitude to Prof. Sari Thomas, Head of

the Department of Statistics, Mar Athanasius College, Kothamangalam and other faculty

members of Department of Statistics for their valuable advice and encouragement to

complete this work.

Finally, I express my heartiest thanks to my dear friends, who helped me in

one way or the other to complete my project successfully in a time schedule and above all to

the almighty for making this possible.

Kothamangalam, SIJI ELSA PAUL

05/06/2018
 CONTENTS

CHAPTER 1 INTRODUCTION

1.1 Statistics 1

1.2 Statistical data analysis 2

1.3 Applications 3

1.4 Description of the Data 5

1.5 Statistical software under study 8

1.6 Organisation of the project 9

CHAPTER 2 CORRELATION

2.1 Introduction 11

2.2 Pearson r correlation 11

2.3 Kendall rank correlation 12

2.4 Spearman’s rank correlation 12

2.5 Analysis of the data 13

2.6 Conclusion 14

CHAPTER 3 CHI-SQUARE TEST FOR INDEPENDENCE

3.1 Introduction 15

3.2 Chi-square test for independence 16

3.3 Analysis of the data 17

3.4 Conclusion 18
CHAPTER 4 MULTIPLE REGRESSION

4.1 Introduction 19

4.2 Regression model 19

4.3 Assumption 20

4.4 Analysis of the data 21

4.5 Conclusion 24

CHAPTER 5 PRINCIPAL COMPONENT ANALYSIS

5.1 Introduction 25

5.2 Objective 25

5.3 Principal component 26

5.4 Assumption 26

5.5 Implementing PCA on a 2-D dataset 27

5.6 Analysis of the data 28

5.7 Conclusion 32

CONCLUSION 33

REFERENCES 34