Dr.N.

Damodharan
Professor and head
Department of pharmaceutics
SRM college of pharmacy

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Definition:

¾ Result of mixing of two or more antagonistic

substances

¾formation of undesirable products.

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Reasons for Incompatibility:

™ Interaction of one drug with other drug

™ Interaction of drug with additives

™ Dosage errors

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` Types of incompatibility

¾ Physical

¾ Chemical

¾ Therapeutic

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PHYSICAL INCOMPATIBILITY

Immiscibilty

Insolubility
Precipitation
Liqeufaction
Physical complexion

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` Chemical incompatibility – two types
1.Tolerated
2. Adjusted
3. Intentional
4. Unintentional
Precipitate yeilding interactions
Diffusible precipitate—Method A—to overcome
Indiffusible precipitate –Method B –to overcome

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` Chemical incompatibility

--ÆAlkaloidal

9 Alkaloidal salt with alkaline substances

9 Alkaloidal salts with soluble iodides

9 Alkaloidal salts with tannins

9 Alkaloidal salts with salicylates

9 Alkaloidal salts with soluble iodides and bromides

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-ÆSoluble salicyates incompatibility

Soluble salicylates with ferric salts

Soluble salicylate with alkali bicarbonates

--Æ Soluble iodides incompatibility

Oxidation of iodides with ferric salts

Oxidation of iodides with Potassium chlorate

Oxidation of iodides with quinine sulphate

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` -Æ Chemical incompatibilities causing evolution of carbon
dioxide

` Soluble bicarbonate with soluble calcium and magnesium

salts

` Bismuth subnitrate and sodium bicarbonate

` Borax with sodium bicarbonate and glycerin.

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Miscellaneous chemical incompatibilites

Soluble barbiturates with ammonium bromide

Potassium chlorate with oxidisible substances

Incompatibility of emulsifying agents

Colour stability of dyes

Incompatibilities of liquorice liquid extract

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 THERAPEUTIC INCOMPATIBILITY:

Prescribing certain drugs to patient with the intention

To produce specific degree of pharmacological action

but the nature or intensity of action produced is

different from that intended by prescriber.

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REASONS:

‰ Wrong dose
‰ Wrong drug
‰ Wrong dosage form
‰ Wrong route
‰ Synergism
‰ Antagonism
‰ Contraindication
‰ Drug interactions

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