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SHERRI A. OLSEN, MultiCare Health Systems, 315 Martin Luther King Jr.
Way, Tacoma, WA
Introduction
surveyed had visited a provider of CAM in the last 6 months. The results
showed that individuals seeing a primary care doctor only reported a 34% CAM
usage; individuals seeing a single specialty doctor (i.e. neurologist) reported a
38% CAM usage; and individuals receiving comprehensive care reported a 53%
CAM usage.
In a nationwide US survey of 3,140 MS patients, Nayak et al. (2003) found
that 57.1% of MS patients had used one CAM; 70.2% of those individuals had
used three or more CAM therapies, for an average of 5.02 CAMs. In a 3-year
longitudinal study of 621 MS patients in the southwest US, Stuifbergen and
Harrison (2003) surveyed participants regarding 12 CAM therapies. Results
indicated 33% currently used 1 of 12 CAM therapies and 50% had tried a CAM
therapy in the past. Apel et al. (2006) examined the frequency of use of 254
MS patients at two neurology clinics in Germany. Their findings suggested
67.3% of individuals were currently using a CAM, for an average of 2.7 therapies.
Of those individuals using CAM, 90.6% use it as a complement to conventional
therapy and 9.4% use it as an alternate. Another study in Germany with 154
MS neurology patients found 61.7% of the patients were currently using CAM,
averaging 2.4 therapies (Apel et al., 2005). Of those individuals using CAM,
90.3% use the therapy as a complement and 9.7% as an alternative to conven-
tional treatment. In a survey of 1,667 MS patients in Oregon and Washington,
Shinto et al. (2006) reported CAM use as 87.9% have ever used, 71.1% currently
use, 16.9% have used in past and 12.1% have never used. Finally, Campbell et
al. (2006) explored CAM use in 451 veterans. Thirty-seven per cent of the
respondents reported current or past CAM use. Thirty-three per cent reported
using two or more interventions. (Refer to Table 1 for summary of frequency
data and response rates.)
There is some evidence that physicians are not aware of the full extent of
their patients’ use of CAM. For example, a survey of 150 primary care physicians
in the United States, completed by Giveon et al. (2003), found that 68% of the
physicians estimated that up to 15% of their patients use CAM. Fifty-three per
cent of the physicians estimate that up to 15% of their patients use herbs. Fifty-
per cent of the physicians surveyed estimated that 10% of their patients report
use of herbal remedies. Eisenberg et al. (1993, 1998, 2001) reported that in the
general population, 39.8 and 38.5% of patients, respectively, discussed CAM
therapies with their conventional medical doctor (M.D.).
There is reference throughout the literature that individuals may turn to CAM
therapies because of dissatisfaction with conventional medicine (Giveon et al.,
2003). Although, in a national qualitative study of 100 US military veteran
CAM users, Kroesen et al. (2002) suggest that although there were particular
aspects of the conventional care system that were criticized, dissatisfaction is
Occup. Ther. Int. 16(1): 57–70 (2009)
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60 Olsen
not a major factor. For example, results suggested a desire for more holistic care.
Participants specifically referred to conventional medicines inadequate informa-
tion regarding diet, nutrition and exercise, as well as ignorance of spiritual
dimensions as a reason to turn to CAM. Results also suggested dissatisfaction
with conventional medicines reliance on prescription medications as an impor-
tant component in veterans’ motivation to use CAM. Instead of finding the
choice of CAM being due to dissatisfaction, Astin (1998) found the choice of
CAM alternatives being due to having more congruency with the values, beliefs
and philosophical orientations of life and health: a holistic perspective.
For individuals with MS, conventional medicine does not treat many of the
symptoms and offers no cure (Freeman et al., 2001). Fawcett et al. (1994)
reported that 63% of the individuals in the United States with MS reported
seeking CAM because conventional medicine offered no cure for MS. Anec-
dotal evidence, or hearing about another person’s success, was the reason given
for choosing CAM therapy by 68% of the respondents in the Berkman et al.
(1999) article. Other reasons for choosing CAM included; traditional treatment
did not bring symptom relief (56.4%), traditional treatment offered no cure for
MS (54.5%), condition was worsening and CAM was only hope (47.5%), a friend
persuaded me (39.6%) and my doctor recommended it (37.6%). The holistic
nature of CAM was the reason it was chosen by 63.4% of US respondents in a
Occup. Ther. Int. 16(1): 57–70 (2009)
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Use of complementary medicine with multiple sclerosis 61
TABLE 3: Why complementary and alternative medicine (CAM) therapy is not chosen
at all
survey done by Nayak et al. (2003). Fifty-one per cent felt that conventional
healthcare had not been effective; more control over their own healthcare was
the reason stated by 36.7% of respondents. Only 15.3% in Nayak’s study indi-
cated their physician recommended CAM treatment. CAM therapies were
chosen based on information from the media (50%), or family/friends (50%),
based on responses from individuals in a Canadian survey done by Page et al.
(2003). See Table 2 for summary of statistics for reasons CAM is chosen.
CAM. Page et al. (2003) found in their research that lack of knowledge about
CAM therapies (42%) and satisfaction with current care provider were reasons
for not using CAM.
CAM effectiveness
of the patients. Minor side effects were reported for 3.7 of the CAM therapies,
including; exercise, vitamins, relaxation, massage, traditional Chinese medi-
cine, hippotherapy, magnetic field therapy, cannabis and enzyme therapy.
In a randomized pilot study of naturopathic medicine in individuals with
MS, Shinto et al. (2008) investigated the quality of life impact of naturopathic
intervention using a three-arm, parallel-group, randomized clinical trial. Forty-
five subjects were randomized to either (1) naturopathic treatments plus usual
care; (2) usual care alone or (3) MS focused educational visits with a nurse plus
usual care. The intervention period was 6 months. On the primary outcome
measure of quality of life there was no significant difference between groups.
There were also no significant differences between groups for the secondary
outcome measures of fatigue, depression, disability and cognitive impairment.
Symptoms treated
Numbness, weakness and vision were the primary symptoms reported as being
treated by the patients in the study by Fawcett et al. (1996). In the Berkman
et al. (1999) study, benefits mentioned included less fatigue, more energy/strength,
overall good health, stress relief, pain relief, improved memory, less numbness,
better bowel and bladder control, less spasticity and depression relief. Slowing
of progression or facilitation of a remission as the reason for CAM use was
mentioned only 12.1% of the time. Page et al. (2003) reported that 68% of their
patients use CAM to improve their health and 61% use CAM to manage symp-
toms; specific symptoms were not provided. Nayak et al. (2003) found that CAM
was primarily used for symptom relief (73.9%), slowing of progression (52.2%),
relapse prevention (33.6%) and induced remission (26.7%). The most frequently
listed symptoms that were treated include, all MS symptoms (86.6%), pain
(59.5%), fatigue 57.8%) and stress (37.9%). Pucci et al. (2004) reported 66% of
the 61 CAM interventions used by the patients in their study were for the
treatment of symptoms; the other 34 were disease modifying.
Being aware of the various reporting methods used in the literature is important
when analyzing and comparing data. For example, Fawcett et al. (1994, 1996)
and Apel et al. (2006) provided participants an open-ended questionnaire about
therapies received for MS; whereas in the Berkman et al. (1999); Page et al.
(2003); and Stueifbergen and Harrison (2003) studies, participants were pre-
sented with a fixed list of options to choose from. Another example of differ-
ences in reporting methods among studies is the timeframe when the CAM was
used by the participant. For example, Astin (1998), Eisenberg et al. (1998) and
Barnes et al. (2004)used the past 12 months as the timeframe; whereas others
Occup. Ther. Int. 16(1): 57–70 (2009)
Copyright © 2009 John Wiley & Sons, Ltd DOI: 10.1002/oti
64 Olsen
use current and/or lifetime as the timeframe for CAM use (Nayak, et al. 2003;
Stuifbergen and Harrison 2003; Shinto et al. 2006).
Vitamins and diets (40%), acupuncture (35.4%), Shaklee natural nutritional
products (29.9%), and chiropractic and relaxation (23%) were the favoured
CAM used by the patients in the research done by Pleines (1992). Although a
per cent is not given, Pleines does report that in the majority of cases, there
was no medical supervision of the CAM. When the data from the Fawcett
et al. (1994, 1996) studies was combined, the most frequently used CAM thera-
pies were physical therapy (44%), nutrition counselling, massage and psychologi-
cal therapy counselling (38%). Thirty-one per cent of the combined sample used
homeopathy, acupuncture or dental therapy. The study by Schwartz et al. (1999)
examined the use of CAM providers rather than the use of CAM products
without guidance from a provider. The therapies received in the last 6 months
include massage (14%), chiropractic (12%), nutritional (9%), holistic (6%), herbal,
healing touch, and acupuncture (3%), faith healing (1%) and bee sting (0.2%).
Berkman et al. (1999) reported on the past or current use from a comprehensive
list of specific CAM treatments. No time frame was attached to the past use.
The CAM therapies used were reported as massage (33.6%), chiropractic (29.3%),
vitamin C (29.3%), acupuncture (27.9%), meditation (22.9%), vitamin E (22.9%),
visualization (22.1%), yoga (16.4%), homeopathy (12.1%), vitamin B complex
(12.1%), marijuana (10.7%), and calcium/magnesium and other B vitamins
(8.6%). The other 29 CAM treatments listed were used by ≤5% of the respon-
dents who had ever used a CAM.
The respondents of the Somerset et al. (2001) study reported on the use of
‘self-treatments’ in the previous 12 months. Use was reported as evening prim-
rose oil (47%), multivitamins (37%), special diets (18%) and cannabis (8%).
Hanyu et al. (2002) analyzed data from the 1999 National Health Interview
Survey, which collected data on CAM use in the past 12 months. The three
most commonly used therapies were spiritual healing/prayer (13.7%), herbal
medicine (9.6%) and chiropractic therapies (7.6%). In Stuifbergen and Harri-
son’s (2003) 3-year longitudinal study, nutritional supplements, massage, special
diets, chiropractic treatment and herbal treatment were the most frequently
used CAMs. The current use (at the end of the 3-year study) for each of these
therapies was reported as; nutritional supplements (60.5%), massage (20.8%),
special diets (45.4%), chiropractic treatment (22.9%) and herbal treatment
(49.1%). There was no significant correlation between continued use after 3
years and perceived effectiveness. Table 4 shows the results of the research by
Apel et al. (2006). There is a breakdown between complementary and alterna-
tive use, and the subjective therapeutic effects of the top six currently used
CAM therapies reported by the patients in the study. These results also show
no significant correlation between specific CAM use and perceived
effectiveness.
DOI: 10.1002/oti
Occup. Ther. Int. 16(1): 57–70 (2009)
Use of complementary medicine with multiple sclerosis
65
66 Olsen
Discussion
The use of CAM by the general public has increased steadily since the 1950s
and the evidence suggests this trend will continue in the foreseeable future
(Kessler et al., 2001). The findings of this research indicate the use of CAM by
individuals with MS tends to be slightly higher than in the general public. CAM
usage among the chronically ill tends to be higher than in the general popula-
tion (Berkman et al., 1999; Page et al., 2003). It becomes more of a risk to MS
patients, because as the prevalence of CAM usage continues to increase, it is
occurring with a lack of strong evidence to support the effectiveness of the
treatments. Even with the absence of controlled research, there remains limited
relationship between the frequency of use and reported perceived effectiveness
of CAM use. In a review of randomized controlled trials, Huntley (2006) found
the research lacked strong methodology, including small sample sizes and there
being only one or two trials done for each of the treatment approaches. This
increases the risk of type II error and makes it difficult to generalize the findings
to the larger MS population.
A potential weakness of this literature review is selection bias because of the
relatively low response rates of most of the studies, which threatens the internal
(rigor of the study) and external (generalizability) validity of the findings. Most
of the studies recruited subjects from MS chapters. This decreases the ability to
generalize to the larger population of people with MS. Many of the studies also
have small sample sizes. Limitations of the review also resulted because of rec-
ognized problems comparing the results of utilization surveys. In particular,
there are differing definitions used in the surveys for CAM. Specifically, some
surveys list the CAM therapies for the individual to choose from, while others
have open-ended questions, allowing the individual to fill in the CAM(s) he
uses. There are also differences in the time periods of use referred to in the
surveys (e.g. current vs. used in last 6 months vs. lifetime use vs. past use). These
differences contribute to considerable variation in the prevalence of use
reported.
Other patterns emerging from the literature review include the use of CAM
therapies as a complement to conventional medicine (National Center for
Health Statistics, 2008). Individuals do not tend to give up their conventional
healthcare providers in lieu of CAM treatment (Berkman et al., 1999; Apel
et al., 2006). The trend is to use CAM as an adjunct to the treatment being
received from a conventional M.D. Another pattern that emerged was the use
of CAM to treat or manage MS symptoms. Although a small percentage of
patients do seek CAM for disease modifying purposes, significantly more patients
use CAM to treat or manage the daily symptoms (Nayak et al., 2003; Page
et al., 2003; Barnes et al., 2004; Pucci et al., 2004). In the surveys reviewed,
the most frequently used CAM therapies include; massage, acupuncture, chiro-
practic, vitamins/herbs and nutrition.
Acknowledgement
The author wishes to thank Martha Hartgraves, PhD, OTR/L, CLT, OT Gradu-
ate Program Director at Rocky Mountain University of Health Professions,
Provo, Utah, for her assistance with this project while she was a doctoral student
at the university.
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Address correspondence to Sherri A. Olsen, 18006 - 64th St. E., Lake Tapps, WA 98391, USA
(E-mail: olsenls1515@msn.com).