5 Star Best Tier - Rank 5; Level 65

Base Duped Signature Synergy

Captain America IW Archangel Iron Man Infinity War Ghost
(
She-Hulk Star-Lord
Domino Medusa
Spider-Man Stark Enhanced Iceman
Captain Marvel Hyperion
Emma Frost Blade
Corvus Glaive Nick Fury
Mister Sinister Doctor Voodoo
Gamora Void
Omega Red
Ghost Rider
Annihilus
Ægon

5 Star Better Tier (Demi-god Tier) Rank 4; Level 55

* – Champions with * sign is available as 4-star only, and you can max them out.
Base Duped Duped + Signature Duped + Synergy
Quake Vision (Both Version) (Scarlet
D ) Witch* Darkhawk
Wolverine -X23 Wolverine* Black Widow Night Thrasher
Hela Proxima Midnight
Masacre Morningstar
Sabretooth Carnage
Symbiote Supreme
Magik
Venom the Duck
Killlmonger
Hulk Ragnarok (GHulk)
Spider Gwen
Havok
Gwenpool
Venom
Luke Cage
The Champion
Thing
Red Hulk (Rulk)

The Good Tier Champions

Champs That You can Rank 3 / 45 or 5 / 50 in case of 4-star.
* – Champions with * sign is available as 4-star only, and you can max them out.
Base Duped Signature Synergy
Hawk-Eye Taskmaster ( D ) Captain Marvel (Classic) ( D + S )
Diablo Thor ( D ) Ms. Marvel ( D + S ) Spider-Man Symbiote ( T )
Dormammu Hulk ( D ) Phoenix ( D + S )
Doctor Octopus Storm ( D ) Thor Ragnarok ( D + S )
Heimdall Mephisto ( D )
Yondu Ultron (Both Version) ( D )
Drax Winter Soldier ( D )
Crossbones Iron Fist (Both Version) ( D )
Angela Yellow Jacket ( D )
Wasp
Bishop
Human Torch
Rogue
Guillotine
Sentinel
The Hood
M.O.D.O.K
Nebula

The Okay Tier Champions

Base Duped Signature Synergy
Electra Black Bolt ( D ) Daredevil Classic ( D + S )
Punisher Black Panther (Classic) ( D )
Nightcrawler
Goldpool
Dr. Strange
Mordo
Korg
Deadpool (Red)
Red Skull
Kingpin
Green Goblin
Cable
Psylocke
Captain America (Both: Classic and WWII)
Thanos

The Badluck Tier (If you are not pulling good champs, you can work with these)
Base Duped Signature Synergy
Beast Deadpool X-Force ( D )
Sentry King Groot ( D )
Kang Thor (Jane Foster) ( D )
Karnak Cyclops (Both Version) ( D )
Spider-Man Miles Morales Juggernaut ( D )
Civil Warrior Magneto (Both Version) ( D )
Ronan Daredevil (Netflix) ( D )
Loki Electro ( D )
Punisher 2099
Agent Venom
Spiderman (Classic)
Old Man Logan
Moon Knight

The Worst Tier or Meh Tier (You are not supposed to upgrade these fellows for offense team)
Base Duped Signature Synergy
Colossus
Falcon
Iron Man
Vulture
Abomination
Gambit
Black Panther (CW)
Unstoppable Colossus
Iron Patriot
War Machine
Kamala Khan
Venompool
Groot
Ant-Man
Hulk Buster
Rhino
Rocket Raccoon
Howard The Duck
Superior Iron Man
Joe Fixit
an Symbiote ( T )

with these)
 4 Star to Rank 5
Mutant
No. Champion Offense Defense Prestige Awakened
1 Archangel ✓ ✓
2 Domino ✓ ✓
3 Emma Frost ✓ ✓ ✓
4 Havoc ✓ ✓ ✓
5 Iceman ✓ ✓ ✓
6 Mister Sinister ✓ ✓ ✓
7 Nightcrawler ✓
8 OG Deadpool ✓ ✓
9 Omega Red ✓ ✓ ✓
10 Rogue ✓ ✓
11 Sabretooth ✓ ✓
12 Wolverine ✓ ✓
13 X23 ✓

Skill
No. Champion Offense Defense Prestige Awakened
1 Blade ✓ ✓ ✓
2 Killmonger ✓ ✓
3 Aegon ✓ ✓ ✓
4 Gwenpool ✓
5 Massacre ✓ ✓
6 Korg ✓
7 Hawkeye ✓
8 Nick Fury ✓ ✓ ✓
9 Crossbones ✓
10 Black Widow ✓ ✓

Science
No. Champion Offense Defense Prestige Awakened
1 Void ✓ ✓ ✓
2 Luke Cage ✓ ✓ ✓
3 Red Hulk ✓ ✓
4 Hulk Ragnarok ✓ ✓
5 Capt. America IW ✓
6 Quake ✓ ✓
7 Thing ✓ ✓ ✓
8 MODOK ✓ ✓
9 Spiderman Classic ✓ ✓
10 Wasp ✓ ✓ ✓
11 Electro ✓
12 Hulk ✓ ✓ ✓

Mystic
No. Champion Offense Defense Prestige Awakened
1 Doctor Voodoo ✓ ✓
2 Ghost Rider ✓
3 Magik ✓ ✓ ✓
4 Scarlet Witch ✓ ✓ ✓
5 Symbiote Supreme ✓
6 Dormammu ✓ ✓ ✓
7 Morningstar ✓ ✓
8 Mephisto ✓

Cosmic
No. Champion Offense Defense Prestige Awakened
1 Hyperion ✓ ✓ ✓
2 Medusa ✓ ✓ ✓
3 Corvus Glaive ✓ ✓
4 Angela ✓
5 Venom ✓ ✓ ✓
6 Hela ✓ ✓
7 The Champion ✓ ✓ ✓
8 Thor ✓ ✓
9 Proxima Midnight ✓ ✓ ✓
10 Miss Marvel ✓ ✓
11 Capt. Marvel (Classic) ✓ ✓ ✓
12 Capt. Marvel ✓ ✓ ✓
13 Gamora ✓

Tech
No. Champion Offense Defense Prestige Awakened
1 Stark Spidey ✓ ✓ ✓
2 Ghost ✓ ✓ ✓
3 Star Lord ✓ ✓
4 Vision (Both) ✓ ✓ ✓
5 Iron Man IW ✓
6 Sentinel ✓ ✓
7 Doctor Octopus ✓ ✓ ✓
8 Ultron ✓ ✓
9 Darkhawk ✓ ✓ ✓