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  • Renal

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    Sammuel1324
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    This document provides definitions for levels of minimum alveolar concentration (MAC) for various anesthetic gases in young, healthy, unpremedicated adults: 1) 1.5 MAC is the concentration at which 50% of patients will have a blunted autonomic nervous system response to surgical stimulus. 2) 1.3 MAC is the concentration at which 95% of patients will not move in response to surgical stimulus. 3) 1 MAC is the concentration at which 50% of patients will not move in response to surgical stimulus. 4) 0.6-0.8 MAC is the concentration at which most patients will have loss of awareness. 5) 0.3

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    This document provides definitions for levels of minimum alveolar concentration (MAC) for various anesthetic gases in young, healthy, unpremedicated adults: 1) 1.5 MAC is the concentration at which 50% of patients will have a blunted autonomic nervous system response to surgical stimulus. 2) 1.3 MAC is the concentration at which 95% of patients will not move in response to surgical stimulus. 3) 1 MAC is the concentration at which 50% of patients will not move in response to surgical stimulus. 4) 0.6-0.8 MAC is the concentration at which most patients will have loss of awareness. 5) 0.3

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    19 vues2 pages

    Renal

    Transféré par

    Sammuel1324
    This document provides definitions for levels of minimum alveolar concentration (MAC) for various anesthetic gases in young, healthy, unpremedicated adults: 1) 1.5 MAC is the concentration at which 50% of patients will have a blunted autonomic nervous system response to surgical stimulus. 2) 1.3 MAC is the concentration at which 95% of patients will not move in response to surgical stimulus. 3) 1 MAC is the concentration at which 50% of patients will not move in response to surgical stimulus. 4) 0.6-0.8 MAC is the concentration at which most patients will have loss of awareness. 5) 0.3

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 2

    MAC

    1.5 MAC MACBAR


    MAC at which 50% of patients will have blunted ANS
    response (rise in HR/BP) in response to standard surgical
    stimulus. (ie stops stress response to surgery)
    1.3 MAC MACSUPER
    MAC at which 95% of patients will not move in response to
    surgical stimulus (ED95)
    1 MAC MAC
    MAC at which 50% of patients will not move in response to
    surgical stimulus (ED95)
    0.6-0.8 MAC at which most patients will have loss of awareness
    MAC
    0.3-0.5 MACAWAKE
    MAC MAC at which 50% of patients will open eyes to verbal
    stimulus (safe extubation)
    0.1 MAC Airway reflex resume

    All are in young, healthy, unpremedicated adults


    MAC expressed as percentage at 1 atm ambient temperature after 15
    delivery to allow equilibration to brain effect site.

    Renal

    Hormone Trigger Site of Action Action


    Angiotensin II Release of renin from 1° aff < eff arterioles Vasoconstriction GFR
    JGA via SNS
    +
    stimulation ( 1 Direct effect on PCT Na reabsorption
    receptors), local
    baroreceptor Adrenal
    ( stretch) Aldosterone release
    Aldosterone
    +
    ATII, K plasma, CD
    n
    induces prod of Thirst,
    Principal cells K
    +
    n +
    ACTH; prod in Na,K-ATPase excretion/Na absorption
    +
    adrenal cortex (zona (basloateral) & K Type A cells H
    n
    glomerulosa) channels (luminal) secretion ( K reabsorp )
    n
    ADH Post pituitary 2° CD cAMP - mediated 2O reabsorp
    n n
    (vasopressin) stim by insertion of ‘aquaporins’ urea reabsorp
    hypothalamus into duct membranes medullary osmolarity
    +
    Stimulates K
    ( n + n
    sec /Na absorp
    ANP atrial stretch Constrict efferent / GFR
    dilate afferent arteriole /
    Kf

    Inhibit RAA system ATII / Aldosterone

    ADH thirst / urine


    + n
    CD Inhibits Na reabsorp
    (likely only a very
    PTH
    2+
    ]extracellular PCT small n
    n
    -adrenergic stim
    Late DCT 2+ n
    reabsorp (
    as well)

    By Amanda Diaz

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