COMBINED LIST OF DRUGS THAT PROLONG QT AND/OR CAUSE TORSADES DE POINTES (TDP)

CredibleMeds® has reviewed available evidence for the drugs on the following list and
place them in one of three designated categories: Known Risk of TdP (KR), Possible Risk
of TdP (PR) or have a Conditional Risk of TdP (CR). The full description of these
categories can be found on the CredibleMeds.org website.

Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Abarelix (PR) Plenaxis Bedaquiline (PR) Sirturo Clomipramine (PR) Anafranil
Aclarubicin (KR) Aclacin and others Bendamustine (PR) Treanda and others Clotiapine (PR) Entumine
Alfuzosin (PR) Uroxatral Bendroflumethiazide Clozapine (PR) Clozaril and others
or bendrofluazide Aprinox and others
Alimemazine Cobimetinib (PR) Cotellic
Nedeltran and others (CR)
(trimeprazine) (PR)
Cocaine (KR) Cocaine
Benperidol (PR) Anquil and others
Amantadine (CR) Symmetrel and others
Crizotinib (PR) Xalkori
Bepridil (KR) Vascor
Amiodarone (KR) Cordarone and others
Cyamemazine
Betrixaban (PR) Bevyxxa Tercian
Amisulpride (CR) Solian and others (cyamepromazine) (PR)
Bortezomib (PR) Velcade and others
Elavil (Discontinued Dabrafenib (PR) Tafinlar
Amitriptyline (CR)
6/13) and others Bosutinib (PR) Bosulif
Dasatinib (PR) Sprycel
Amphotericin B (CR) Fungilin and others Buprenorphine (PR) Butrans and others
Degarelix (PR) Firmagon and others
Amsacrine (acridinyl Cabozantinib (PR) Cometriq
Amsidine Delamanid (PR) Deltyba
anisidide) (CR)
Capecitabine (PR) Xeloda
Desipramine (PR) Pertofrane and others
Anagrelide (KR) Agrylin and others
Ceritinib (PR) Zykadia
Deutetrabenazine (PR) Austedo
Apalutamide (PR) Erleada
Aquachloral and
Chloral hydrate (CR) Dexmedetomidine (PR) Precedex and others
Apomorphine (PR) Apokyn and others others
Dextromethorphan/Quinidine
Aripiprazole (PR) Abilify and others Chloroquine (KR) Aralen Nuedexta
(PR)
Arsenic trioxide (KR) Trisenox Chlorpromazine (KR) Thorazine and others
Diphenhydramine (CR) Benadryl and others
Artemether + Cilostazol (KR) Pletal
Coartem Disopyramide (KR) Norpace
Lumefantrine (PR)
Cimetidine (CR) Tagamet and others
Dofetilide (KR) Tikosyn
Artenimol+piperaquine
Eurartesim Ciprofloxacin (KR) Cipro and others
(PR) Dolasetron (PR) Anzemet
Cisapride (KR) Propulsid
Asenapine (PR) Saphris and others Domperidone (KR) Motilium and others
Citalopram (KR) Celexa and others
Astemizole (KR) Hismanal Donepezil (KR) Aricept
Clarithromycin (KR) Biaxin and others
Atazanavir (CR) Reyataz and others Doxepin (CR) Sinequan and others
Clofazimine (PR) Lamprene
Atomoxetine (PR) Strattera
Azithromycin (KR) Zithromax and others

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over
Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Dronedarone (KR) Multaq Granisetron (PR) Kytril and others Levomethadyl acetate (KR) Orlaam
Droperidol (KR) Inapsine and others Grepafloxacin (KR) Raxar Levosulpiride (KR) Lesuride and others
Efavirenz (PR) Sustiva and others Halofantrine (KR) Halfan Lithium (PR) Eskalith and others
Eliglustat (PR) Cerdelga Haloperidol (KR) Haldol (US & UK) and others Lofexidine (PR) Lucemyra
Encorafenib (PR) Braftovi Hydrochlorothiazide (CR) Apo-Hydro and others Imodium and many other
Loperamide (CR)
OTC and Rx brands
Eperisone (CR) Myonal and others Hydrocodone - ER (PR) Hysinglaâ„¢ ER and others
Lopinavir and ritonavir (PR) Kaletra and others
Epirubicin (PR) Ellence and others Hydroquinidine,
Serecor
dihydroquinidine (KR) Maprotiline (PR) Ludiomil and others
Eribulin mesylate (PR) Halaven
Hydroxychloroquine (CR) Plaquenil and others Melperone (PR) Bunil and others
Erythromycin (KR) E.E.S. and others
Hydroxyzine (CR) Atarax and others Namenda XR and many
Escitalopram (KR) Cipralex and others Memantine (PR)
others
Ibogaine (KR) None
Esomeprazole (CR) Nexium and others
Mesoridazine (KR) Serentil
Ibutilide (KR) Corvert
Ezogabine (Retigabine)
Potiga and others Methadone (KR) Dolophine and others
(PR) Iloperidone (PR) Fanapt and others
Metoclopramide (CR) Reglan and others
Famotidine (CR) Pepcid and others Imipramine (melipramine)
Tofranil
(PR) Metolazone (CR) Zytanix and others
Felbamate (PR) Felbatol
Indapamide (CR) Lozol and others Metronidazole (CR) Flagyl and many others
Fingolimod (PR) Gilenya
Inotuzumab ozogamicin (PR) Besponsa Midostaurin (PR) Rydapt
Flecainide (KR) Tambocor and others
Isradipine (PR) Dynacirc Mifepristone (PR) Korlym and others
Fluconazole (KR) Diflucan and others
Itraconazole (CR) Sporanox and others Mirabegron (PR) Myrbetriq
Fluorouracil (5-FU) (PR) Adrucil and others
Ivabradine (CR) Procoralan and others Mirtazapine (PR) Remeron
Fluoxetine (CR) Prozac and others
Ivosidenib (PR) Tibsovo Moexipril/HCTZ (PR) Uniretic and others
Flupentixol (PR) Depixol and others
Ketanserin (PR) Sufrexal Moxifloxacin (KR) Avelox and others
Fluvoxamine (CR) Faverin and others
Ketoconazole (CR) Nizoral and others Necitumumab (PR) Portrazza
Furosemide (frusemide)
Lasix and others
(CR) Lacidipine (PR) Lacipil and others Nelfinavir (CR) Viracept
Galantamine (CR) Reminyl and others Lansoprazole (CR) Prevacid Nicardipine (PR) Cardene
Garenoxacin (CR) Geninax Lapatinib (PR) Tykerb and others Nilotinib (PR) Tasigna
Gatifloxacin (KR) Tequin Lenvatinib (PR) Lenvima Norfloxacin (PR) Noroxin and others
Gemifloxacin (PR) Factive Leuprolide (Leuprorelin) (PR) Lupron and others Nortriptyline (PR) Pamelor and others
Gilteritinib (PR) Xospata Levofloxacin (KR) Levaquin and others Nusinersen (PR) Spinraza
Glasdegib (PR) Daurismo Levomepromazine Ofloxacin (PR) Floxin
Nosinan and others
(methotrimeprazine) (KR)

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over
 Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name
Olanzapine (CR) Zyprexa and others Propafenone (CR) Rythmol SR and others Telithromycin (PR) Ketek
Omeprazole (CR) Losec and others Propofol (KR) Diprivan and others Terfenadine (KR) Seldane
Ondansetron (KR) Zofran and others Prothipendyl (PR) Dominal and others Terlipressin (KR) Teripress and others
Osimertinib (PR) Tagrisso Quetiapine (CR) Seroquel Terodiline (KR) Micturin and others
Oxaliplatin (KR) Eloxatin Quinidine (KR) Quinaglute and others Tetrabenazine (PR) Nitoman and others
Oxytocin (PR) Pitocin and others Quinine sulfate (CR) Qualaquin Thioridazine (KR) Mellaril and others
Paliperidone (PR) Invega and others Ranolazine (CR) Ranexa and others Tiapride (PR) Tiapridal and others
Palonosetron (PR) Aloxi Ribociclib (PR) Kisqali Tipiracil and Trifluridine (PR) Lonsurf
Panobinostat (PR) Farydak Rilpivirine (PR) Edurant and others Tizanidine (PR) Zanaflex and others
Pantoprazole (CR) Protonix and others Risperidone (PR) Risperdal Tolterodine (PR) Detrol and others
Papaverine HCl (Intra- Romidepsin (PR) Istodax Toremifene (PR) Fareston
none
coronary) (KR)
Roxithromycin (KR) Rulide and others torsemide (torasemide) (CR) Demadex and others
Paroxetine (CR) Paxil and others
Saquinavir (PR) Invirase(combo) Tramadol (PR) Crispin and others
Pasireotide (PR) Signifor
Sertindole (PR) Serdolect and others Desyrel (discontinued 6/13)
Trazodone (CR)
Pazopanib (PR) Votrient and others
Sertraline (CR) Zoloft and others
Pentamidine (KR) Pentam Trimipramine (PR) Surmontil and others
Sevoflurane (KR) Ultane and others
Perflutren lipid microspheres Tropisetron (PR) Navoban and others
Definity and others Solifenacin (CR) Vesicare
(PR)
Valbenazine (PR) Ingrezza
Sorafenib (PR) Nexavar
Perphenazine (PR) Trilafon and others
Vandetanib (KR) Caprelsa
Sotalol (KR) Betapace and others
Pilsicainide (PR) Sunrythm
Vardenafil (PR) Levitra
Sparfloxacin (KR) Zagam
Pimavanserin (PR) Nuplazid
Vemurafenib (PR) Zelboraf
Sulpiride (KR) Dogmatil and others
Pimozide (KR) Orap
Venlafaxine (PR) Effexor and others
Sultopride (KR) Barnetil and others
Pipamperone (PR) Dipiperon (E.U) and others
Voriconazole (CR) VFend
Sunitinib (PR) Sutent
Piperacillin/Tazobactam
Tazosyn and Zosyn Vorinostat (PR) Zolinza
(CR) Tacrolimus (PR) Prograf and others
Ziprasidone (CR) Geodon and others
Posaconazole (CR) Noxafil and others Nolvadex(discontinued 6/13)
Tamoxifen (PR)
and others Zotepine (PR) Losizopilon and others
Primaquine phosphate (PR)
Telaprevir (CR) Incivo and others Zuclopenthixol, Zuclopentixol
Probucol (KR) Lorelco Cisordinol and others
(PR)
Telavancin (PR) Vibativ
Procainamide (KR) Pronestyl and others
Promethazine (PR) Phenergan

Note: Medicines on this list are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. Because, the list changes regularly, we
recommend always checking the website at crediblemeds.org for the most up-to-date information. Most drugs have multiple brand names and it is not practical to list them on this form. The
CredibleMeds.org website provides a partial list of the more common brands.

Disclaimer and Waiver: The information presented here is intended solely for the purpose of providing general information about health-related matters. It is not intended for any other
purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users’ relationships with their own health care providers. To that extent, by use of
this list and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any claims arising out of his/her use of this list. The Terms of Use
Agreement for this list and the CredibleMeds website is available at https://www.crediblemeds.org/terms. The absence of drugs from these lists should not be considered an indication that
they are free of risk of QT prolongation or torsades de pointes. Few medicines have been tested for this risk in patients, especially those with congenital long QT syndrome. This list and the
CredibleMeds® website are intended for personal and professional use only and are protected by U.S. Copyright (title 17, U.S. Code). Unauthorized commercial use is prohibited.

Generated: May 23, 2019. List last revised: March 29, 2019