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Sporozoa (Apicomplexa) • Mostly enteric disease caused by the genera Eimeria and
Isospora
– Major economic disease of poultry
• Resistance
• Rotation and shuttle programs – changing the mode of action within a
batch of broilers
– Rapid lifecycle, massive environmental contamination
– Any young animal
– Act on extracellular stages, intracellular stages or sporulation
Ionophores
• Transport cations across membranes
– Cause osmoregulatory difficulties
– Extracellular merozoites, sporozoites
– Fermentation products
• 5 classes of drug
– Resistance to a drug in one class will confer
resistance within that class but not to the 4 others
– Toxic to horses and turkeys
– Generally in feed medications
• Divalent polyether
– Lasolocid (Bovatec)
• Monovalent polyethers
– May not be co-administered with some antibiotics - • Monovalent monoglycoside polyether
Tiamulin – Semiduramicin (Aviax)
– Maduramycin (Cygro)
• Monensin (Rumensin, Coban) • 5 day withdrawal period
– Cattle, broilers, goats
– Also a growth promoter in ruminants • Toltrazuril (Baycox)
• Alters microbial fauna in rumen →↓ VFA loss – Triazine
– No withdrawal pre-slaughter – Poultry and mammals
• Salinomycin – Water administration
– Poultry only – Broad spectrum anticoccidial and antiprotozoal
– Active v sexual and asexual stages
– Sporozoites, and intracellular asexual stages – T1/2 of 51 hours in piglets
• Narasin (Monteban) – 14 day WHP, not in layers
– Broilers only – Also active v Hepatozoon canis and possibly Neospora caninum
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• Amprolium • Clopidol (Lerbek)
– Thiamine analogue – Pyridinol
– First generation schizont – Sporozoite
– E tenella principally
• Robenidine (Cycostat)
– Guanidine derivative
• Sulphonamides – 1st generation schizonts
– First effective anticoccidials used – WHP of 5 days
– Active v asexual stages - schizonts • Nicarbazin (Carbigran)
– Not used in poultry anymore – 2nd generation trophozoites
– Prevention not treatment
– Ruminants, dogs, cats
– 4 day WHP
– Often used in combination with dihydrofolate – Not for layers
reductase/thymidylate synthase inhibitors eg – In combination with narasin = Maxiban
trimethoprim
• BZs
– High doses given at 12 or 24 hour intervals for 2 or 3 days Resistance
– Fenbendazole
• FBZ 50 mg/k daily for 3 days in dogs • What is Resistance?
• FBZ 5-20 mg/kg daily for 3 days in calves The ability of a pest to
– Febantel be able to withstand
• 27-35 mg/kg/day for 3 days in dogs
the effect of a
– Albendazole
• 25 mg/kg b.i.d. for 2 days
chemical
• Trimethoprim • What causes
– Acanthamoeba
Resistance?
• Doxycycline Common factors are:
– Entamoeba, Balantidium, Toxoplasma
• Human antiprotozoal drugs have been used with some – Under-dosing
successes in dogs. Some are registered for animal use OS – Increased frequency
– Primaquine, quinacrine, atovaquone, decoquinate, furazolidine,
meglumine antimonate, paramomycin, enrofloxacin, azithromycin – Improper coverage
• See small animal pharmacology, Maddison, Page, Church, 2nd edition 2008,
Saunders/Elsevier, Philadelphia USA. – Poor application
– Poor mixing
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Resistance to parasiticides
• SPs - resistance in buffalo flies, ticks, flies, fleas,
lice.
• OP/carbamate - resistance is increasing and
widespread in places - flies, ticks, fleas
• Amitraz - widespread resistance in ticks
• BZs
• Levamisole/pyrantel
• Salicylanilides
• MLs
• Multi-resistant strains occur – ticks, fleas, worms,
flies
• Sheep blowflies are still susceptible to cyromazine
Resistance to chemicals
• 2 general mechanisms
– major single gene mutation, dominant, rare
event 1 in 106-8 individuals - eg dieldrin and OP
resistance in flies.
– genetic shift in many relevant genes - eg
anthelmintic resistance
• Selection pressure
– select only resistant individuals (square decay
curve).
– slow decline in residues may select for many
genes that contribute to resistance (residue tail)
– Cost of resistance - R is less fit eg cyromazine
Development of Resistance
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Development of Resistance Development of Resistance