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Life Science > Metabolomics > Learning Center > Amino Acids Reference Chart
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Detergents Amino acids are the 21 standard compounds or building blocks that make up peptides and proteins, including DNA. Each amino acid is structured
from an amino group and a carboxyl group bound to a tetrahedral carbon. This carbon is designated as the α-carbon (alpha-carbon).
Cell Biology Amino acids differ from each other with respect to their side chains, which are referred to as R groups. The R group for each of the amino acids will
differ in structure, electrical charge, and polarity.
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Refer to the charts and structures below to explore amino acid properties, types, applications, and availability.
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Arginine Arg R 174.20 C6H14N4O2 C6H12N4O 156.19 2.17 9.04 12.48 10.76
Aspartic acid Asp D 133.11 C4H7NO4 C4H5NO3 115.09 1.88 9.60 3.65 2.77
Cysteine Cys C 121.16 C3H7NO2S C3H5NOS 103.15 1.96 10.28 8.18 5.07
Glutamic acid Glu E 147.13 C5H9NO4 C5H7NO3 129.12 2.19 9.67 4.25 3.22
Histidine His H 155.16 C6H9N3O2 C6H7N3O 137.14 1.82 9.17 6.00 7.59
Lysine Lys K 146.19 C6H14N2O2 C6H12N2O 128.18 2.18 8.95 10.53 9.74
Tyrosine Tyr Y 181.19 C9H11NO3 C9H9NO2 163.18 2.20 9.11 10.07 5.66
1 pKa is the negative of the logarithm of the dissociation constant for the -COOH group.
2 pKb is the negative of the logarithm of the dissociation constant for the -NH group.
3
3 pKx is the negative of the logarithm of the dissociation constant for any other group in the molecule.
Reference: D.R. Lide, Handbook of Chemistry and Physics, 72nd Edition, CRC Press, Boca Raton, FL, 1991.
The hydrophobicity index is a measure of the relative hydrophobicity, or how soluble an amino acid is in water. In a protein, hydrophobic amino acids
are likely to be found in the interior, whereas hydrophilic amino acids are likely to be in contact with the aqueous environment.
The values in the table below are normalized so that the most hydrophobic residue is given a value of 100 relative to glycine, which is considered
neutral (0 value). The scales were extrapolated to residues which are more hydrophilic than glycine.
At pH 2A At pH 7B
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Very Hydrophobic
Phe 92 Trp 97
Trp 84 Leu 97
Val 79 Val 76
Met 74 Met 74
Hydrophobic
Cys 52 Tyr 63
Tyr 49 Cys 49
Ala 47 Ala 41
Neutral
Thr 13 Thr 13
Glu 8 His 8
Gly 0 Gly 0
Ser -7 Ser -5
Asp -18
Hydrophilic
Asp -55
ApH 2 values: Normalized from Sereda et al., J. Chrom. 676: 139-153 (1994).
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The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal development.
Polleux F1, Ghosh A.
2002 Jun 11;2002(136):pl9.
We have developed a technique that allows characterization and identification of extracellular signals that regulate various aspects of neuronal differentiation. In this
in vitro assay, dissociated cells isolated from the developing cerebral wall are labeled and cultured over organotypic cortical slices. We have used this slice Read
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