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To cite this article: Pooja Vyas, Dinesh Kumar Yadav & Poonam Khandelwal (2018): Tectona
grandis (teak) – A review on its phytochemical and therapeutic potential, Natural Product Research,
DOI: 10.1080/14786419.2018.1440217
REVIEW
1. Introduction
Tectona is a genus of tropical hardwood trees belongs to Lamiaceae family. This family
includes about 236 genera and 6900 to 7200 species (Kuete 2017). The genus Tectona com-
prises 3 species viz T. grandis, T. hamiltoniana and T. philippinensis, T. grandis (teak) is widely
distributed in Bangladesh, Thailand, China, India, and Pakistan. Tectona hamiltoniana (Dahat
4. Pharmacology
Over the past decades, numerous researchers have investigated the pharmacological activ-
ities of teak. Summary of the pharmacological properties are given in Table 1.
Some interesting pharmacological properties are discussed below.
NATURAL PRODUCT RESEARCH 3
compounds with reported cytotoxicity also present in teak (Sandermann and Simatupang
1966; Cichewitz and Kouzi 2004). In vivo, experiments also provided that T. grandis exerts
potential cytotoxic activity, as summarized in Table 6.
(Continued)
NATURAL PRODUCT RESEARCH 9
Table 8. (Continued).
Compound name (Molecular formula) Plant part & References
MONOTERPENE
37. (6RS)-(E)-2,6-Dimethyl-2,7-octadiene-1,6-diol Leaves (Macias et al. 2008)
(C10H18O2)
SESQUITERPENES
38. lβ-6α-Dihydroxy-4(15)-eudesmene (C15 H26O2) Leaves and Bark (Macias et al.2010)
39. 7-Epieudesm-4(15)-ene-1α,6α-diol (C15 H26O2) Leaves and Bark (Macias et al. 2010)
DITERPENES
40. Abeograndinoic Acid (C20H32O4) Leaves and Bark (Macias et al. 2010)
41. Phytol (C20H40O) Leaves and Bark (Macias et al. 2010)
42. 7,11,15-Trimethyl-3-methylene-hexadecan-1,2-diol Leaves and Bark (Macias et al. 2010)
(C20H40O2)
43. Rhinocerotinoic acid (C20H30O3) Leaves and Bark (Macias et al. 2010)
44. 2-Oxokovalenic acid (C20H30O3) Leaves and Bark (Macias et al. 2010)
45. 19-Hydroxyferruginol (C20H30O2) Leaves and Bark (Macias et al. 2010)
46. Tectograndinol (C20H34O3) Leaves (Horst and Ilona 1977)
47. Solidagonal acid (C20H30O3) Leaves and Bark (Macias et al. 2010)
TRITERPENES
48. Lupeol (C30H50O) Bark (Pathak et al. 1988)
49. Betulin (C30H50O2) Bark (Pathak et al. 1988)
50. Betulinaldehyde (C30H48O2) Bark (Pathak et al.1988)
51. Betulinic acid (C30H48O3) Heartwood and Stem bark (Sandermann and Simatupang
1966; Khan et al. 2010) Bark (Ahluwalia and Seshadri 1957)
Roots (Dayal and Seshadri 1979) Leaves (Kopa et al. 2014)
52. Ursolic acid (C30H48O3) Leaves (Kopa et al. 2014); Bark (Macias et al. 2010)
53. Corosolic acid (C30H48O4) Leaves (Kopa et al. 2014)
54. Oleanolic acid (C30H48O3) Leaves and Bark (Macias et al. 2010)
55. Maslinic acid (C30H48O4) Leaves and Bark (Macias et al. 2010)
56. Methyl-2α,3α-dihydroxyurs-l2-en-28-oate (C30H48O4) Leaves and Bark (Macias et al. 2010)
57. Euscaphic acid (C30H48O5) Leaves and Bark (Macias et al. 2010)
58. Squalene (C30H50) Roots (Windeisen et al. 2003; Khan and Mlungwana 1999)
POLYTERPENE OR RUBBER
59. Caoutchouc or Indian rubber Polymer Wood (Sandermann and Dietrichs 1959; Narayanamurti and
Singh 1960; Yamamoto et al. 1998)
APOCAROTENOIDS
60. Tectoionol A (C13H23O3) Leaves (Macias et al. 2008)
61. Tectoionol B (C13H24O2) Leaves (Macias et al. 2008)
62. Annuionone D (C13H20O3) Leaves (Macias et al. 2008)
63. 3β-Hydroxy-7,8-dihydro-β-ionol (C13H24O2) Leaves (Macias et al. 2008)
64. 9(S)-4-Oxo-7,8-dihydro-β-ionol (C13H22O2) Leaves (Macias et al. 2008)
65. 3β-Hydroxy-7,8-dihydro-β-ionone (C13H22O2) Leaves (Macias et al. 2008)
PHENOLIC COMPOUNDS
66. Gallic acid (C7H6O5) Leaves (Nayeem and Karvekar 2010)
67. Ellagic acid (C14H6O8) Leaves (Nayeem and Karvekar 2010)
68. Acetovanillone (C9H10O3) Leaves (Lacret et al. 2012)
69. E-Isofuraldehyde (C10H10O3) Leaves (Lacret et al. 2012; Macias et al. 2004)
70. 3-Hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl) Leaves (Lacret et al. 2012)
propan-1-one (C11H14O5)
71. Evofolin A (C17H1806) Leaves (Lacret et al. 2012)
FLAVONOIDS
72. Rutin (C27H30O16) Leaves (Nayeem and Karvekar 2010)
73. Quercitin (C15H10O7) Leaves (Nayeem and Karvekar 2010)
STEROIDS/ SAPONINS
74. β-Sitosterol (C29H50O) Roots (Joshi et al. 1977; Dayal and Seshadri 1979)
75. Hydroxyenone (C29H48O2) Leaves and Bark (Macias et al. 2010)
76. β-Sitosterol-β-d-[4′linolenyl-6′-(tridecan-4′″-one-1′″- Stem bark (Khan et al. 2010)
oxy)] Glucuranopyranoside (C66H110O8)
77. Stigmast-5-en-3-O-β-d-glucopyranoside (C35H60O6) Stem bark (Khan et al. 2010; Misra et al. 2008)
78. Sitosterol 3-O-β-d-glucopyranoside (C60H100O7) Leaves (Kopa et al. 2014; Singh et al. 2010)
(Continued)
10 P. VYAS ET AL.
Table 8. (Continued).
Compound name (Molecular formula) Plant part & References
PHENYLPROPANOIDS : LIGNANS
79. Syringaresinol (C22H26O8) Leaves (Lacret et al. 2012; Macias et al. 2004)
80. Medioresinol (C21H24O7) Leaves (Lacret et al. 2012; Macias et al. 2004)
81. 1-Hydroxypinoresinol (C20H22O7) Leaves (Lacret et al. 2012)
82. Lariciresinol (C20H24O6) Leaves (Lacret et al. 2012; Macias et al. 2004)
83. Balaphonin (C20H20O6) Leaves (Lacret et al. 2012)
84. Zhebeiresinol (C14H16O6) Leaves (Lacret et al. 2012)
PHENYLPROPANOIDS : NORLIGNANS
85. Tectonoelin A (C18H16O6) Leaves (Lacret et al. 2012)
86. Tectonoelin B (C19H18O7) Leaves (Lacret et al. 2012)
PHENYLETHANOID GLYCOSIDE
87. Verbascoside or acteoside (C29H36O15) Leaves (Singh et al. 2010)
FATTY ESTERS
88. 7′-Hydroxy-n-octacosanoyl n-decanoate(C28H56O3 Stem bark (Khan et al. 2010)
89. 20′-Hydroxyeicosanyl linolenate (C38H72O3) Stem bark (Khan et al. 2010)
90. 18′-Hydroxy-n-hexacosanyl-n-decanoate (C36H72O3) Stem bark (Khan et al. 2010)
MISCELLANEOUS
91. n-Docosane (C22H46) Stem bark (Khan et al. 2010)
92. O-Tolylmethylether (C8H10O) Wood (Dharmcharee 1957)
esters and miscellaneous compounds. These discrepancies suggest that further investigation
of the chemical constituents of T. grandis will provide interesting information regarding the
chemistry of this species.
Disclosure statement
No potential conflict of interest was reported by the authors.
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