DE LA SALLE HEALTH SCIENCES INSTITUTE

COLLEGE OF MEDICINE
Department of Pharmacology
School Year: 2017 – 2018

CLINICAL PHARMACOLOGY
EVALUATION # 3
August 31, 2017

ANSWER KEY
NAME: ____________________________________________ STUDENT NO. __________

GENERAL DIRECTIONS: Choose the best answer. (75 items)

TOPICS COVERED:
- Rational Treatment of Fever (20 points)
- Rational Treatment of Peptic Ulcer Disease (25 points)
- Prescription Writing (30 points)

A. RATIONAL TREATMENT OF FEVER

Identification. Choose from the choices below

A. Aspirin
B. Connective Tissue Disease
C. Ibuprofen
D. Paracetamol
E. Fever
F. Corticosteroids
G. Prostaglandin E2

STATEMENT ANSWER

1. Possible cause of Fever of Unknown Origin B

2. Induces elevation of hypothalamic set point for temperature G

3. Its oxidized form acts as a cyclooxygenase inhibitor D

4. Has weak anti-inflammatory activity D

5. The drug of choice for fever for adult and children D

6. Associated with development of Reye Syndrome in children A

7. Has antipyretic effects but NEVER recommended as first line treatment F

8. Has anti-platelet effects A

9. A physiologic response and NOT an illness E

10. Common alternative for fever in children and adolescents C

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MATCHIING TYPE. Match Column A with the choices in Column B. Choose the BEST answer.

What would be your medication of choice for the treatment of fever in the following cases:

COLUMN A COLUMN B ANSWER

11. Adult with hypersensitivity to salicylates A. Paracetamol A

12. Fever in patient diagnosed with Kawasaki B. Aspirin B

13. A patient with history of gastric distress C. Ibuprofen A

14. Post vaccination medication D. A or C D

15. 22/M athlete with accompanying joint pains E. A or B C

16. Fever in a 4/F with runny nose A

17. 12/F suspected of Dengue Fever A

18. 35/M admitted for UTI A

19. 60/M with Acute Nasopharyngitis, bacterial A

20. 25/F breastfeeding mom with Mastitis A

B. RATIONAL TREATMENT OF PEPTIC ULCER DISEASE

TRUE OR FALSE: Following each statement are a number of options. For each option choose T
if the option is TRUE and choose F if the option is FALSE.

Superior healing rate of Erosive Esophagitis is achieved with the use of:

OPTIONS ANSWER
21. Omeprazole 20 mg once daily for 4 weeks F

22. Omeprazole 20 mg once daily for 8 weeks T

23. Ranitidine 150 mg twice a day for 8 weeks F

24. Sucralfate 1 ram three times a day for 4 weeks F

The best time to give Omeprazole is:

OPTIONS ANSWER
25. 30 minutes before morning meal T

26. 30 minutes before dinner F

27. Anytime patient is symptomatic F

Non-drug measures for the relief of symptoms of GERD:

OPTIONS ANSWER
28. Weight control T

29. Stop smoking F

30. Left lateral decubitus position T

31. Avoid alcoholic drinks F

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If treatment of GERD using Omeprazole 20 mg once daily with standard duration of treatment
only produce partial relief of symptoms, the next step will be to:

OPTIONS ANSWER
32. Increase dose of Omeprazole to twice daily T

33. Shift to Esomeprazole 40 mg once daily T

34. Shift to Ranitidine 150 mg twice daily F

If patient cannot tolerate the use of Omeprazole due to its adverse effects, what can be an
alternative treatment?

OPTIONS ANSWER
35. Ranitidine T

36. Alginate-Antacid Combination T

37. Misoprostol F

38. Bismuth subsalicylate F

Most common side effect/s of PPI therapy include:

OPTIONS ANSWER
39. Headache T

40. Diarrhea T

41. Constipation T

42. Abdominal pain T

The best recommended treatment of refractory GERD are PPIs at maximum dose and duration
of treatment plus:

OPTIONS ANSWER
43. Ranitidine 300 mg in the evening T

44. Baclofen 10 mg three times a day T

45. Citalopram T

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PRESCRIPTION WRITING FOR RATIONAL TREATMENT OF FEVER
Instruction: Create a prescription using the appropriate drug for the following cases.

DRUG BANK:
a. Paracetamol tablet 500 mg, 1 tab every 6 hours as necessary for fever
b. Paracetamol syrup 250mg/5mL, 5 mL every 4 hours as necessary for fever
c. Ibuprofen suspension 200mg/5mL, 5 mL every 4 hours as necessary for fever
d. Ibuprofen capsule 400 mg, 1 capsule every 6 hours to be taken with food as necessary
for fever

CASE 1
H.K., a 17/F noted on and off fever with a temperature ranging from 38-38.7º Celsius. She also
has dental caries and experiences pain upon chewing associated with slight swelling of the left
side of her face. No other associated signs and symptoms. Write a complete prescription for the
BEST medication for her condition.

Han Kang, 17/F August 31, 2017

Dasmarinas, Cavite

Rx

[Ibuprofen capsule 400 mg]

Dispense No.: [10 capsules]
Label: [Take 1 capsule every 6 hours to be taken with food as necessary for
fever]

DBQ
D.B. Qujano, MD
License No.: 123456
PTR No.: 789123

CASE 2

B.C. 6/M weighing 22 kgs was noted to have fever (T= 37.8º Celsius) after coming home from
school. He has been previously well except for minor cough and colds for the last 2 days in which
increased oral fluid intake was advised. He also complained of having headache and was noted
to have loss of appetite. Write a complete prescription for the BEST medication for his condition.

Ben Chan, 6/M August 31, 2017

Dasmarinas, Cavite

Rx

[Paracetamol Syrup 250mg/5ml]

Dispense No.: [1 bottle (60 mL bottle)]
Label: [Give 5 mL every 4 hours as necessary for fever]

MTT
M.T. Tresmanio, MD
License No.: 456789
PTR No.: 987654

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CASE 3

C.V. 45/F, developed low to moderate grade fever, on and off for the last two days. She has a
history of asthma but currently asymptomatic. Write a complete prescription for the BEST
medication for her condition.

Christine Vasquez, 45/F August 31, 2017

Dasmarinas, Cavite

Rx

[Paracetamol Tablet 500 mg]

Dispense No.: [10 tablets]
Label: [Take 1 tablet every 6 hours as necessary for fever]

NMV
N.M. Villanueva, MD
License No.: 101010
PTR No.: 234567

PRESCRIPTION WRITING FOR RATIONAL TREATMENT OF PEPTIC ULCER DISEASE

Instruction: Create a prescription using the appropriate drug for the following cases.

DRUG BANK:

a. Ranitidine 300 mg once in the evening for 8 weeks (150 mg, 300 mg)
b. Omeprazole 20 mg once a day 30 minutes before breakfast for 8 weeks (20 mg, 40 mg
capsules)
c. Omeprazole 20 mg twice a day 30 minutes before meals for 8 weeks (20 mg, 40 mg
capsules)
d. Sucralfate 1 gram three times a day 30 minutes before meals for 4 weeks (1 gram)
e. Omeprazole 20 mg once a day 30 minutes before breakfast for 4 weeks
Using the BEST recommended drug and treatment regimen, write a complete prescription for:

CASE 1
A 45 year old male with Non-Erosive Reflux Disease (NERD)

Edgar Poe, 45/M August 31, 2017

Dasmarinas, Cavite

Rx

[Omeprazole 20 mg capsule]
Dispense No.: [28]
Label: [Take 1 capsule once a day 30 minutes before breakfast for 4 weeks]

CNN
C.N. Naval, MD
License No.: 123456
PTR No.: 654321

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CASE 2

A 50 year old female with Erosive Esophagitis

Catherine Cruz, 50/F August 31, 2017

Dasmarinas, Cavite

Rx

[Omeprazole 20 mg capsule]
Dispense No.: [56]
Label: [Take 1 capsule once a day 30 minutes before breakfast for 8 weeks]

ABS
A.B. Sanchez, MD
License No.: 222222
PTR No.: 123456

CASE 3

A 60 year old male with Refractory GERD

Roberto Angeles, 60/M August 31, 2017

Dasmarinas, Cavite

Rx

[Omeprazole 20 mg capsule]
Dispense No.: [112]
Label: [Take 1 capsule once a day 30 minutes before breakfast for 8 weeks]

GMA
G.M. Alvarez, MD
License No.: 777777
PTR No.: 654321

------------------ END OF THIRD EVALUATION ------------------

Note: All answers are based on Moodle.

COMPILED BY: Alfonso Martin E. Plantilla, Group 2B2B

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