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Insulin kurang atau gagal memasukan glukosa ke dalam sel (melalui GLUT 4)
Neuropati + iskemi → Kerusakan di arteri yang ada di kaki → ulkus diabetikum. Karena ada
damage, supply darah kurang (karena blockage/sumbatan) → necrosis yg reaksi inflam itu
jg?
The indications for limb amputations are generally considered as the three Ds: dead
limb, deadly limb and a damn nuisance of a limb.
Kerusakan di arteri yang ada di ginjal → atherosclerosis → activate RAAS system → systemic
hypertension → hyperfiltration → glomerular damage (glomerulosclerosis) → proteinuria →
nephrotic syndrome (proteinuria → low albumin, swelling)
Diabetik Nefropathy
Bntr” oh katanya sel” mesangialnya bakal produksi matrix gt makanya jd expanded karena
inflamnya ya? O
Patof”daftar masalah
-ulkus DM grade 2
-anemia nirmositik hipokrom
-CKD grade
-DM
Prognosis
Indikasi trf
-PRC
-whole blood
-TC
Active bleeding in patients with:
o generalized, microvascular active, major or dangerous bleeding or in those who have been
transfused > 1 blood volume or with documented DIC (threshold platelets/microL = 50,000). A
threshold value of up to 100,000 platelets/microL may be appropriate in those with more
minor or less active bleeding.
o acute liver failure (no threshold level set)
o bleeding and a qualitative platelet defect (congenital or acquired) (no threshold level set)
o autoimmune thrombocytopenia with major and/or dangerous bleeding (e.g. severe intestinal,
ocular or intracranial hemorrhage) (no threshold level set)
-TC apheresis
-FFP
-cryoprecipitate
Cryoprecipitate transfusion may be indicated in the following circumstances:
In patients with:
o generalized microvascular, non-surgical bleeding with fibrinogen <100 mg/dL
o factor deficiencies if the specific factor is unavailable
dorsalis pedis, tibialis poste