Gliceril trinitrat (GTN)

Indication :

- Use in surgery
- A starting dose of 25 mcg/min is recommended for the control of hypertension, or to produce
hypotension during surgery. This may be increased by increments of 25 mcg/min at 5 minute
intervals until the blood pressure is stabilised. Doses between 10 - 200 mcg/min are usually
sufficient during surgery, although doses of up to 400 mcg/min have been required in some cases.
- Myocardial ischaemia
- The treatment of perioperative myocardial ischaemia may be started with a dose of 15 - 20
mcg/min, with subsequent increments of 10 - 15 mcg/min until the required effect is obtained.
- Unresponsive congestive heart failure:
- The recommended starting dose is 20 - 25 mcg/min. This may be decreased to 10 mcg/min, or
increased in steps of 20-25 mcg/min every 15 - 30 minutes until the desired effect is obtained.
- Unstable angina:
- An initial dose of 10 mcg/min is recommended with increments of 10mcg/min being made at
approximately 30 minute intervals according to the needs of the patient.

Forms 50 mg in 10 ml ;

GTN
A : 50 mg GTN dalam 10 ml + 40 ml NS = 50 mg gtn dalam 50 ml NS (syringe pump)
B : 50 mg GTN dalam 10 ml + 90 cc NS = 50 mg gtn dalam 100 cc NS (infus pump)
C : 50 mg GTN dalam 10 ml + 90 cc NS = 50 mg gtn dalam 100 cc NS (micro drip)

dosis
(mcg/min) A (cc/jam) B (cc/jam) C (tpm mikro)
10 0.6 1.2 1.2
20 1.2 2.4 2.4
30 1.8 3.6 3.6
40 2.4 4.8 4.8
50 3 6 6
60 3.6 7.2 7.2
70 4.2 8.4 8.4
80 4.8 9.6 9.6
90 5.4 10.8 10.8
100 6 12 12
110 6.6 13.2 13.2
120 7.2 14.4 14.4
130 7.8 15.6 15.6
140 8.4 16.8 16.8
150 9 18 18
160 9.6 19.2 19.2
170 10.2 20.4 20.4
180 10.8 21.6 21.6
190 11.4 22.8 22.8
200 12 24 24
210 12.6 25.2 25.2
220 13.2 26.4 26.4
230 13.8 27.6 27.6
240 14.4 28.8 28.8
250 15 30 30
260 15.6 31.2 31.2
270 16.2 32.4 32.4
280 16.8 33.6 33.6
290 17.4 34.8 34.8
300 18 36 36