US-FDA, 2016

~ Schmieder and
Edwards (2012)
7/13/2019
%
Jacobs. Clin Microbiol Infect 2001;7:589–96
Federico Pea1 and Pierluigi Viale, 2009
 

Federico Pea1 and Pierluigi Viale, 2009

Clinical outcome

Jacobs. Clin Microbiol Infect 2001;7:589–96

[Adapted from Preston et al. JAMA 1998;279:125–9]
 20
18
16 600 mg BID
μ

14 400 mg BID
12 MIC-90 Staph
10 MIC-90 Entero
8 MIC-90 Strep
6
4
2
0
0 5 10 15 20

Linezolid Research Update. Denver, Colo: Infectious Diseases Society of America; November 13, 1998.
 Effect of Creatinine Clearance on the Half Life of an
Antibiotic with a Normal Half Life of 1 Hour

25
20
Half Life in Hours

20
15
10
4
5 1 2
0
Normal 50% Normal 25% Normal 5% Normal
Creatinine Clearance
Pa (r=0.976; p<0.001)
GNB (r=0.891; p<0.001)