Lenalid 10mg - Lenalidominde Natco

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DESCRIPTION

Drug profile
Lenalid10mg price in india containing active substance known as
Lenalidomide which is considered as thalidomide derivative and it is originated
from Generic Revlimid.

Lenalid 10mg side effect is a naturally established compound which plays

important role in myeloma at first, later it is used for hematological disorders
like myelodysplastic syndromes.

Lenalidomide is an Immuno modulatory agent which has both anti-angiogenic

& anti-cancer activity.

Lenalid 10mg price in india is available in the strength of 10mg

Trade name: Lenalid10mg

Active ingredient: Lenalidomide

Strength: 10mg

Mfg: Natco pharma

Pack: 30 tablets in a container

Classified as: Anti-neoplastic drug

Prescribing information of
Lenalid 10mg;
The most important therapeutic indication of Lenalid 10mg side effect is given
below as follows;

v In multiple myeloma

v In myelodysplastic syndrome

v In mantle cell lymphoma

Multiple myeloma:
Lenalid10mg uses (Generic Revlimid) is used in myeloma condition by
combining with dexamethasone

In myeloma patients with autologous hematopoietic stem cell

transplantation, Lenalid10mg price in india is used as a
continuation therapy.

Myelodysplastic syndrome:
Lenalid10mg tablet (Generic Revlimid), is also used in the therapy of
patients with transfusion vulnerable anemia expected low or moderate
exposure of myelodysplastic syndrome related to deletion 5q cytogenetic
aberrant.
Mantle cell lymphoma:
Lenalid10mg uses (Generic Revlimid) is used in mantle cell lymphoma
as a second line therapy. The patient’s disease conditions are reoccurred or
advanced after prior two therapies like Bortezomib.

Drawback of use;
Lenalid10mg price in india is not suggested in chronic lymphocytic
leukemia.

Mechanism of Lenalid 10mg;

Lenalid10mg uses (Generic Revlimid), is a thalidomide analogue.
The pharmacological activity of Lenalid10mg side effect is;
Immuno modulatory

Anti-angiogenic activity

Anti-neoplastic activity

Immuno modulatory effect by;

Elevates the counts and activates the effect of T-cells and natural killer cells

Elevates the count of natural killer T cells

Prohibits the pro-inflammatory cytokines like TNF-alpha & IL-6 monocytes

Anti-neoplastic activity by;
Prohibiting cell multiplication & activates apoptosis of cancer cells in vitro and
causes prohibition of cell growth in vivo, prominently to reduce in tumor strain.

Postponing the growth of cancer cells

Combined effort of dexamethasone leads to inhibits cell replication and

promotes apoptosis in myeloma cells.

Anti-angiogenesis;
Angiogenesis (cell development) is blocked by reducing the levels of VEGF,
TNF-alpha & IL-6.

VEGF: Vascular Endothelial Growth Factor

Lenalid 10mg uses is expel its activity by inhibits the interpretation of cyclo
oxygenase 2 (COX 2) in vitro, it may trigger the apoptosis directly by involving
in prohibition of bone marrow stromal cell backing by anti-angiogenic and anti-
osteoclastogenic activity & by Immuno modulatory effect .

Absorption
After an oral administration of Lenalid10mg price in india , the
absorption occurs very quickly.

The peak plasma concentration time occurs between 0.5 to 6 hours after drug
intake.

Distribution
Lenalid10mg is bounds to human plasma protein at relatively 30%
Lenalidomide is occurs in semen after administration, at 2 hours & 24 hours
after the dose of 25mg Lenalid10mg uses.

Metabolism
The metabolism of Lenalidomide is occurs in limited range, mostly unchanged
form of Lenalidomide is a major circulating substance present in the human
body.

There are two major metabolites like;

5-hydroxy Lenalidomide

N-acetyl Lenalidomide

Not more than 5% of parent form is present in the circulation.

Excretion
The primary elimination of Lenalidomide is occurs via renally.

Nearly 82% of radioactive dose is eliminated in urine within 24 hours; the two
metabolites are excreted in 4.6% & 1.8%.

Total excretion occurs within 10 days.

The terminal half life period of Lenalidomide in healthy person is 3 hours;

whereas in myeloma & MDS or MCL is 3 to 5 hours

When to take the tablet Lenalid 10mg

Lenalid10mg tablet (Generic Revlimid) should be taken with or without
food.
Lenalid10mg capsules should not be opened, broken or chewed.
It should be administered with whole water.

Dosage regimens of Lenalid 10mg

The potency of Lenalidomide is not evaluated in pediatric patients with the
age of <18 years.

In adults;
In myelodysplastic syndrome:
The recommended dosage is 10mg of Lenalidomide should be taken as a
single dose.

In renal damaged patients:

In CrCl 30 to 60ml/min: 5mg of Lenalidomide should be suggested for once a
day.

In CrCl <30ml/min: 2.5mg PO as a single dose

In CrCl >60ml/min: No dosage adjustment is required

Multiple myeloma:
The therapy should be followed by combining of Lenalid 10mg with
dexamethasone as a single dose.

The recommended dose of Lenalid 10mg is 25mg should be given as a

single dose on day 1 to 21 of repeated 28 day cycles.
The dosage of dexamethasone;

For first 4 cycles;

40mg of dexamethasone should be recommended on days 1 to 4; 9 to 12; &

17 to 20 of each 28 day cycles.

Then followed by 40mg should be given as single dose, days 1 to 4 every 28

days

Age >75 years: 20mg of dexamethasone is recommend, on day 1, 8, 15 & 22

of each 28 cycle.

Mantle cell lymphoma:

The recommended dosage of Lenalid 10mg price in india is
25mg should be administered orally as a single dose.

CrCl 30 to 60ml/min: 10mg PO single dose

CrCl <30ml/min: 15mg should be recommend as a single dose.

In ESRD: 5mg should be given

Storage and handling

Lenalid10mg tablets should be stores at 20 C to 25 C; excursion
o o

between 15oC to 30oC.

Keep the container away from heat, moisture & light

Missed dose
The missed dose of Lenalid10mg tablet should be avoided, and follow
the regular dosing schedule.
Over dosage
There is no special treatment for over dosage of Lenalidomide; In case of this
condition patient must be provided with adjuvant therapy and monitor the
signs & symptoms frequently.

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