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DAFTAR PUSTAKA

1. Sandesc, Dorel.Sepsis: A Review.Timosoura Medical Journal [ internet ].2003


[ cited 2014 february 12 ];Available from : Timosoura Medical Journal
2. Medlineplus.Sepsis.[ internet ]. [ 11 February 2014 ; cited 12 february 2014
].Available from :http://www.nlm.nih.gov/medlineplus/sepsis.html.
3. Griffiths Ben , Anderson D lain . Sepsis , SIRS , and MODS .Surgery [
internet ] .Oktober 2009 [ cited 11 february 2014 ] 27, ( 10 ) , 446-449.
4. Martin GS, Mannino DM, Eaton S, Moss M. . The epidemiology of sepsis in
the united states from 1979 through 2000 . N Engl J Med [ internet ] . 2003 ;
[ cited 11 february 2014 ] ; 384 ( 16 ) : 1546 – 54
5. Angus, D.C., walker T , Linda , Jefrey , Josep carlito ,Michael pinsky .
Epidemiology of severe sepsis in the United States: analysis of incidence,
outcome, and associated costs of care . Crit. Care Med [ internet ] . 2001 [
cited 11 February 2012 ].. 29:1303-1310.
6. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in
England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a
high quality clinical database, the ICNARC case mix programme database.
Crit Care [Internet]. 2006 [cited 2012 feb 16;10(2):R42. Availabel from:
PubMed
7. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in
the United States from 1979 through 2000. N Engl J Med [Internet]. 2003
[cited 2012 Feb 16;348:1546-54]. Available from: PubMed

8. Dachlan EG ( 2009 ) Obstetrical sepsis IN the 10th Annual Indonesian


Maternal Fetal Medicine Scientific Meeting .
43

9. Soreng, Katherine, Ph.D., Levy, Roma, M.S. Procalcitonin: an Emerging


Biomarker of Bacterial Sepsis. Clinical Microbiology Newsletter [Internet].
2011 [cited 2011 Nov 30;33(22):171-178]. Available from: SienceDirect .
10. Ferreire FL, Bota DP, Bross A, Mélot C, Vin6. cent JL. Serial evaluation of
the SOFA score to predict outcome in critically ill patients. JAMA. 2001; 286:
1754-8.
11. Karason S, Vestindohtier E , Severe sepsis and septic shock: a prospective
populationbased study in Icelandic intensive care units. EBSCOHost . 2011;
55: 722–731
12. Sakr C, Sphonholz, Reinhart K. Organ dysfuntion in the ICU: a clinical
perspective. In: Vincent JL, ed. 2007 Yearbook of intensive care and
emergency medicine. New York: Springer; 2007. p. 238-43.
13. Tran DD, Groeneveld ABJ, Vander Muelen J, 9. Nauta JJP, Strack VS, Thijs
LG. Age, chronic disease, sepsis, organ system failure, and mortality in a
medical intensive care unit. Crit Care Med. 1990; 18:474-9.
14. Dino halim dkk , Comparison of Apache II, SOFA, and Modified SOFA
Scores in Predicting Mortality of Surgical Patients in Intensive Care Unit at
Dr. Hasan Sadikin General Hospital. Crit Care & Shock (2009) 12:157-169.
15. Vincent J-L, Moreno L, Takala J, Willatts S, De Mendonca A,Bruining H, et
al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe
organ dysfunction/ failure. On behalf of the Working Group on Sepsis-
Related Problems of the European Society of Intensive Care Medicine.
Intensive Care Med. 1996;22(7): 717-20. 16.Dorland . W.A . Newman.
16. Kamus Kedokteran Dorland . Jakarta . ECG. 2002
17. Djoko W. Arya G. 2006 . Penanganan sepsis . DEXA MEDIA Journal
kedokteran dan Farmasi No.2 , Vol. 19 , April – Juni 2006.
18. Hadisaputro S patogenesis Dasar – dasar Pengelolaan Sepsis dan syok sepsis .
Dalam :Majalah Media Medika Indonesia , ed.2 , Semarang . FK Undip,1998
; 37 – 45.
44

19. Bone rl , et all . Definition for sepsis and organ failure and quidelines for the
use o innovative therapies in sepsis ACEP / SCCM . Consensus conference .
Chest . 1992 ; 101 ; 1644 – 55.
20. Hall M , William S , De Frmes C , Golosinky A. Inpatient care for septicemia
or sepsis : A challenger for patient and hospitals . 2011 .
21. The epidemiology of sepsis in the United States from 1979 through 2000 –
NEJM (internet ). ( cited 2012 Dect ) . Available from : http : // www.nejm .
org / doi / full / 10.1056 / NEJ Moa 022139.
22. John Warren MD. 1994 . Sepsis . Dasar Biologi dan klinis Penyakit Infeksi
Edisi keempat . Gadjah Mada Uneversity Press Yogyakarta Pp:521 .
23. Franchini M , Lippi G, Manzato F . Recent acquiltion in the patophysiology ,
diagnosis , and treatment of disseminated intravaskuler coagulation .
Trombosis Journal . 2006 ; 4 ; 4 – 12 .
24. Raghavan, Murugan, E. Marik, Paul. Management of sepsis during the early
„golden hours‟. Critical Care Medicine [Internet]. 2006 [cited 2011 Nov
30;31(2):185-199]. Available from: ScienceDirect .
25. E.D., Carrol et al. Review: Procalcitonin as a marker of sepsis. International
Journal of Antimicrobial Agent [Internet]. 2002 [cited 2011 Nov 30;20:1-9].
Available from: ScienceDirect .
26. Graves DT, Naguib G, Lu H, Leone C, Hsue H, Krall E. Inflammation is more
persistent in type 1 diabetic mice. J Dent Res. 2005;84(4):324–32840.Spatz M
EN, Hink S, Wolf HM, Fischer GF, Mayr WR, et al. Impaired primary
immune response in type-1 diabetes. Functional impairment at the level of
APCs and T-cells. Cell Immunol. 2003;221(1):15-26.
27. Schuetz P, Castro P, Shapironi. Diabetes and sepsis: Preclinical findings and
clinical relevance. Diabetes Care [internet]. 2011 [cited: 2013 Jan 21]; 34 (3):
771-778. Available from: care.diabetesjournals.org/content/34/3/771.short.
45

28. PubMed Health. Cancer. Carcinoma; Malignant tumor. C2012 [updated: 2012
Sept3,cited:2013Jan29].Availablefrom:http://www.ncbi.nlm.nih.gov/pubmedh
ealth/PMH0002267/.
29. Sjamsuhidajat, de Jong W. Buku ajar ilmu bedah. Jakarta: EGC; 2010
30. Price SA, Wilson LM. Patofisiologi vol 1: konsep klinik proses-proses
penyakit. Trans. Pendit BU, Hartanto H, Wulansari P, Mahanani DA. Jakarta:
EGC; 2005.
31. O’Callaghan C. At a Glance Sistem Ginjal (Terjemahan). 2nd ed. Safitri A,
Astikawati R, editors. Jakarta: Penerbit Erlangga; 2009.
32. Suwitra K. Penyakit ginjal kronik. In: Sudoyo AW, Setiyohadi B, Alwi I, K
MS, Setiati S, editors. Buku ajar Ilmu Penyakit Dalam. 1 ed. Jakarta: Pusat
Penerbitan Departemen Ilmu Penyakit Dalam FKUI; 2006. p. 570-3.
33. Rubenstein D, Wayne D, Bradley J. Lecture Notes: Kedokteran Klinis
(Terjemahan). In: Rahmalia A, Safitri A.Penyakit Ginjal. 6th ed. Jakarta:
Penerbit Erlangga; 2007. p. 228-31.
34. Guyton AC, Hall JE. Buku Ajar Fisiologi Kedokteran (Terjemahan). 11 ed.
Rachman RY, Hartanto H, Novrianti A, Wulandari N, editors. Jakarta: EGC;
2007. p. 423-35.
35. Sepsis Allience . Sepsis and Surgery [ internet ].[ 2014 : cited 12 February
2014 ].Available from : http://www.sepsisalliance.org/sepsis_and/surgery/
36. Mangunnegoro H, dkk. PPOK, Pedoman Diagnosis dan Penatalaksanaan di
Indonesia. Perhimpunan Dokter Paru Indonesia: 2003. hal 1-56 .
37. Evans TW, Smithies M. ABC of intensive care: organ dysfunction.Med J.
1999;318:1606-9.
38. Balk RA. Pathogenesis and management of multiple organ dysfunction or
failure in severe sepsis and septic shock. Critical Care Clinics
2000;16(2):337-52.
46

39. McKinlay J, Bihari D. Multiple organ dysfunction. Dalam: Bersten AD, Soni
N, Oh TE [ed.]. Oh’s intensive care manual. 5th ed London: Butterworth
Heinemann. 2003.p.113-26.
40. Vincent J-L. Septic shock. Dalam: Fink MP, Abraham E, Vincent J-L,
Kochanek PM eds. Textbook of critical care. 5th ed. Philadelphia; Elsevier:
2005.p.1259-65.
41. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ.
Multiple organ dysfunction score: a reliable descriptor of a complex clinical
outcome. Crit Care Med. 1995;23 (10):1638-52.
42. Rooij S, Abu – Hanna A , Levi M , Jonge E. Factor that predict outcome of
intensive care treatment in very elderly patient : a review . Critical Care. 2005
; 307 – 14.
43. Vera , Evacuasinya Endang , Richardo Yuvens. Karakteristik Pasien Usia
Lanjut di Ruang Rawat Intensif Rumah Sakit Immanuel Bandung .2011 Feb 2
. Jurnal JKM.10:110-119.
44. Sistem manajemen RSUP dr. Kariadi . Kebijakan RSUP dr. Kariadi .
Semarang . Februari 2013.
45. Departemen Kesehatan . Standart Pelayanan ICU . Available from : <
http://www.depkes.go.id>(Accesed 27 September 2012 ).2008.
46. Vosylius S,Sipylaite J, Ivaskevicius J. Determinant of outcome in elderly
patient admitted to the intensive care unit . J Age and ageing .2005 ; 34 : 157
– 62.
47. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al.

Sepsis in European intensive care units: results of the SOAP study. Crit Care

Med [internet]. 2006 [cited 2010 Oct 4]. 34(2):344-353. Available from:

http://www.ccmpitt.com
47

48. Sunaryo Aries, Sri Redjeki Ike, Bisri tatang. Perbandingan validasi APACHE

II dan SOFA score untuk memperkirakan mortalitas pasien yang dirawat di

ruang perawatan intensif.2012.2: 1 :

49. Roberto Ceriani, Maurizio Mazzoni, Franco Borton.Application of the

Sequential Organ Failure Assesment Score to cardiac Surgical patient.

Clinical Investigations in Critical Care. 2003. 4:123

50. Vincent, Jean-Louis MD, PhD, FCCM; deMendonca, Arnaldo MD , et all .

Use of the SOFA score to assess the incidence of organ dysfunction/failure in

intensive care units : Results of a multicenter, prospective study. Crit Care

Med [internet]. 1998 26(11), pp 1793-1800

51. Osborn, Tiffany Medlin MD,Tracy, J Kathleen PhD et all.Epydemiology of

sepsis in patient with traumatic injury. Critical Care Medicine.2004.11.23

52. Alfani , Diana Lalenoh dkk .Hubungan skor SOFA dengan lama rawat inap

pasien cedera kepala berat di ICU RSUP prof. Dr. R. D. Kandou Periode juni

2012- oktober 2013.

53. Bakker J, deLima AP. Increased blood lactate levels: An important warning

signal in surgical practice. Crit Care Med. 2004; 8: 96-7.


48

LAMPIRAN

LAMPIRAN 1. Biodata Penulis

Identitas

Nama : Nurul Ahmad Isnaini

NIM : 22010110130187

Tempat/Tanggal lahir : Lamongan, 16 Oktober 1991

Jenis Kelamin : Laki - laki

Alamat : Jln. Bulusan Selatan

No HP : 085641695349

Email : ahmadnurul63@yahoo.com

Riwayat Pendidikan Formal

1. SD : SDN Balun 2

2. SMP : SMPN 1 Lamongan

3. SMA : SMAN 2 Lamongan

4. Universitas : FK UNDIP
49

Lampiran 2. Ethical Clearance


50

Lampiran 3. Surat Izin Penelitian


51

Lampiran Data Output

1. Data kategorik
a. Jenis Kelamin

Jenis Kelamin
Frequency Percent Valid Percent Cumulative
Percent
Laki - laki 27 60.0 60.0 60.0
Valid Perempuan 18 40.0 40.0 100.0
Total 45 100.0 100.0

b. Penyakit Komorbid

Penyakit Komorbid
Frequency Percent Valid Percent Cumulative
Percent
Stroke 5 11.1 11.1 11.1
Gagal Ginjal 3 6.7 6.7 17.8
DM 3 6.7 6.7 24.4
Tumor 5 11.1 11.1 35.6
HAP 1 2.2 2.2 37.8
DIC 5 11.1 11.1 48.9
Pneumonia 14 31.1 31.1 80.0
Valid Infeksi 2 4.4 4.4 84.4
PPOK 2 4.4 4.4 88.9
CHF 1 2.2 2.2 91.1
AIHA 1 2.2 2.2 93.3
HIV Aids 1 2.2 2.2 95.6
Peritonitis 1 2.2 2.2 97.8
SNH 1 2.2 2.2 100.0
Total 45 100.0 100.0
52

c. Usia Skor < 9

Usia Skor < 9


N Minimum Maximum Mean Std. Deviation
skor < 9 21 18 70 49,48 18,052
Valid N (listwise) 21

d. Usia > 9

Usia > 9
N Minimum Maximum Mean Std. Deviation
Skor > 9 24 23 70 52,63 13,197
Valid N (listwise) 24

e. Hidup / meninggal < 9

skor < 9
Cumulative
Frequency Percent Valid Percent Percent
Valid 24 53,3 53,3 53,3
hidup 5 11,1 11,1 64,4
meninggal 16 35,6 35,6 100,0
Total 45 100,0 100,0

f. Hidup / meninggal > 9

Skor > 9
Cumulative
Frequency Percent Valid Percent Percent
Valid 21 46,7 46,7 46,7
53

meninggal 24 53,3 53,3 100,0


Total 45 100,0 100,0

2. Uji Normalitas

Tests of Normality
Kolmogorov-Smirnova Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
SkorSofa ,171 45 ,002 ,929 45 ,008
LamaRawat ,207 45 ,000 ,781 45 ,000
a. Lilliefors Significance Correction

3. Uji korelasi Spermen

Correlations
TransSofa TransRawat
Spearman's rho TransSofa Correlation Coefficient 1,000 -,214
Sig. (2-tailed) . ,158
N 45 45
TransRawat Correlation Coefficient -,214 1,000
Sig. (2-tailed) ,158 .
N 45 45
54

DATA PENELITIAN

KORELASI ANTARA SKOR SOFA DENGAN LAMA RAWAT INAP PASIEN


SEPSIS
DI ICU RSUP DR KARIADI

NILAI NILAI LAMA


SKOR SKOR HARI
JENIS SOFA SOFA NILAI RAWAT skor < Skor
NO NO.CM UMUR KELAMIN KOMORBID 1 2 SKOR 9 >9 Skor < 9 Skor >9
C
1 389415 59 laki Stroke 13 16 16 2 59 Stroke
C Gagal
2 395205 61 Perempuan Ginjal 5 9 9 17 61 gagal ginjal
C
3 392367 34 Laki DM 12 12 17 34 DM
C
4 392186 51 Perempuan Tumor 12 8 12 1 51 Tumor
C
5 400417 63 laki HAP 5 5 8 63 Hap
C
6 380110 45 laki DIC 9 9 9 7 45 DIC
C
7 396745 70 Perempuan Pneumonia 6 7 7 9 70 Pneumonia
C
8 359592 18 Perempuan Pneumonia 6 6 6 20 18 Pneumonia
C
9 396092 23 laki Infeksi 10 9 10 39 23 Infeksi
C
10 400132 65 laki PPOK 5 5 5 10 65 PPOK
C
11 115712 70 laki PPOK 8 9 9 2 70 PPOK
C
12 247852 60 laki Pneumonia 6 5 6 17 60 Pneumonia
C
13 392582 20 laki Pneumonia 6 5 6 17 20 Pneumonia
C
14 393842 54 Perempuan DIC 15 11 15 12 54 DIC
C
15 396293 37 laki Pneumonia 9 9 2 37 Pneumonia
16 C 60 laki Tumor 9 9 3 60 Tumor
55

403513
C Gagal
17 397883 50 laki Ginjal 5 5 10 50 gagal ginjal
C
18 401973 70 Perempuan Pneumonia 12 12 6 70 Pnemonia
C
19 400603 63 Perempuan Pneumonia 17 17 17 2 63 Pneumonia
C
20 397823 70 Perempuan Stroke 14 14 2 70 Stroke
C
21 401148 49 Laki CHF 8 8 1 49 CHF
C
22 396639 63 Perempuan Tumor 7 9 9 9 63 Tumor
C Gagal
23 400794 35 laki Ginjal 15 12 15 1 35 gagal ginjal
A
24 548574 50 laki Pneumonia 14 13 14 1 50 Pneumonia
A
25 401496 58 laki DIC 19 18 19 4 58 DIC
C
26 403277 70 laki DIC 7 7 8 70 DIC
C
27 380540 28 Perempuan Infeksi 4 4 9 28 Infeksi
C
28 279140 25 Perempuan Pneumonia 7 8 8 31 25 Pneumonia
C
29 404070 66 laki Stroke 11 12 12 4 66 Stroke
C
30 401039 39 Perempuan AIHA 4 4 4 39 AIHA
C
31 401799 30 laki HIV Aids 8 7 8 8 30 HIV Aids
C
32 402848 38 Laki Peritonitis 8 8 8 6 38 Peritonitis
C
33 086769 57 Perempuan Pneumonia 7 7 17 57 Peritonitis
C
34 398309 34 Perempuan Tumor 5 5 2 34 Tumor
C
35 403755 34 Laki DM 14 11 14 38 34 DM
B
36 240467 43 Perempuan Pneumonia 15 17 17 5 43 Pneumonia
C
37 069721 45 laki Stroke 15 15 15 30 45 Stroke
56

C
38 401496 58 laki Pneumonia 17 18 18 4 58 Pneumonia
C
39 325971 55 laki SNH 8 8 14 55 SNH
C
40 398921 50 Laki DIC 11 11 1 50 DIC
C
41 405251 66 Perempuan Tumor 4 4 3 66 Tumor
B
42 216650 62 laki DM 4 4 5 62 DM
C
43 221502 70 Perempuan Pneumonia 4 4 6 70 Pneumonia
C
44 130393 70 laki Pneumonia 4 4 4 70 Pneumonia
C
45 246013 64 Perempuan Stroke 9 9 3 64 Stroke
57

Lampiran 6. Dokumentasi Penelitian

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