PMID- 31369638

OWN - NLM
STAT- In-Data-Review
LR - 20190801
IS - 1932-6203 (Electronic)
IS - 1932-6203 (Linking)
VI - 14
IP - 8
DP - 2019
TI - Use of antidepressants and risks of restless legs syndrome in patients with
irritable bowel syndrome: A population-based cohort study.
PG - e0220641
LID - 10.1371/journal.pone.0220641 [doi]
AB - Previous research has suggested an association between antidepressants use
and
clinical restless legs syndrome (RLS) in patients, but there has never been a
single study investigating the risk of RLS in irritable bowel syndrome (IBS)
patients treated with antidepressants. Hence, we aimed to explore the
association
between IBS and RLS and to examine the risk of RLS in IBS patients treated
with
antidepressants. With the use of the National Health Insurance Research
Database
of Taiwan, 27,437 adults aged >/= 20 years with newly diagnosed IBS (ICD-9-CM
Code 564.1) and gender- and age-matched 54,874 controls without IBS were
enrolled
between 2000 and 2012. All patients were followed-up until RLS diagnosis,
withdrawal from the National Health Insurance program, or end of 2013. We
used
the Cox proportional hazards model to calculate the hazard ratios (HRs) and
95%
confidence intervals (CIs) of RLS. RLS was more prevalent in IBS patients
than in
the non-IBS group (7.57 versus 3.36 per 10,000 person-years), with an
increased
risk of RLS (adjusted HR [aHR], 1.91; 95% CI, 1.52-2.40). Multivariate Cox
proportional hazards analysis identified older age (age, 51-65 years; aHR,
1.67;
95% CI, 1.09-2.56; and age > 65; aHR, 1.59; 95% CI, 1.02-2.48),
hypothyroidism
(aHR, 4.24; 95% CI, 1.92-9.37), CAD (aHR, 1.70; 95% CI, 1.17-2.48), and
depression (aHR, 3.15; 95% CI, 2.14-4.64) as independent RLS risk factors in
IBS
patients. In addition, the male SSRIs users were associated with
significantly
higher risk of RLS (aHR, 3.05 95% CI, 1.34-6.92). Our study showed that the
IBS
group has higher risk of RLS. Moreover, SSRIs use may increase the risk of
RLS in
male IBS patients.
FAU - Hsu, Yung-Chu
AU - Hsu YC
AD - Division of Neurology, Department of Internal medicine, Ditmanson Medical
Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan.
FAU - Yang, Hsin-Yi
AU - Yang HY
AUID- ORCID: http://orcid.org/0000-0002-8571-5202
AD - Clinical Medicine Research Center, Ditmanson Medical Foundation Chia-Yi
Christian
Hospital, Chia-Yi City, Taiwan.
FAU - Huang, Wan-Ting
AU - Huang WT
AD - Clinical Medicine Research Center, Ditmanson Medical Foundation Chia-Yi
Christian
Hospital, Chia-Yi City, Taiwan.
FAU - Chen, Solomon Chih-Cheng
AU - Chen SC
AD - Department of Pediatrics, School of Medicine, College of Medicine, Taipei
Medical
University, Taipei, Taiwan.
AD - Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung
Medical University, Kaohsiung, Taiwan.
FAU - Lee, Herng-Sheng
AU - Lee HS
AD - Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General
Hospital, Kaohsiung, Taiwan.
LA - eng
PT - Journal Article
DEP - 20190801
PL - United States
TA - PLoS One
JT - PloS one
JID - 101285081
SB - IM
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/08/02 06:00
MHDA- 2019/08/02 06:00
CRDT- 2019/08/02 06:00
PHST- 2019/02/20 00:00 [received]
PHST- 2019/07/19 00:00 [accepted]
PHST- 2019/08/02 06:00 [entrez]
PHST- 2019/08/02 06:00 [pubmed]
PHST- 2019/08/02 06:00 [medline]
AID - 10.1371/journal.pone.0220641 [doi]
AID - PONE-D-19-05013 [pii]
PST - epublish
SO - PLoS One. 2019 Aug 1;14(8):e0220641. doi: 10.1371/journal.pone.0220641.
eCollection 2019.