NST 11 Spring 2017

Assignment 1
DUE 2/17/17 11:59pm
Name:
Discussion Section: 102

Multiple Choice: (1 point each)

1. Which of the following is considered safe to be consumed by a pregnant woman and
does not increase the risk of fetal alcohol syndrome?
A. 10 ounces of regular beer per day
B. 3 ounces of wine per week
C. 1 ounce of hard liquor per month
D. None of the above

2. Which of the following enzymes is NOT involved in alcohol metabolism?

A. Alcohol dehydrogenase
B. cAMP phosphodiesterase
C. CYP2E1
D. Aldehyde dehydrogenase

3. The toxic effects of substance X were predicted using a computer software. The
analyses revealed structural analogy between substance X and caffeine. The type of this
study is:
A. In-silico
B. In-vitro
C. In-vivo
D. None of the above

4. Approximately what percentage of lung cancers are due to smoking?

A. 50%
B. 20%
C. 80%
D. 90%
E. None of the above

5. Which of the following is NOT true about Nicotine Dependence?

A. Nicotine stimulates the reward center in the brain
B. Nicotine has a function in weight control and coping with stress
C. Nicotine is one of the most dependence producing drugs
D. Nicotine is as highly addictive as cocaine and heroin
E. Nicotine does not function as a dependence producing drug
True of False (1 point each)
1. True or False? In the toxicity testing of substance X, a dose of 10 mg/kg is the
lowest dose that can cause 100% lethality in a population of mice. The LC50 of
substance X is 5mg/kg.
2. True or False? Hormesis response is likely observed in some nutrients including
vitamins and minerals.
3. True or False? In a laboratory study, the scientists obtained a p53 knockout (loss of
function) mouse line, these knockout mice are generally less likely to get cancer
compared to wild type mice.
4. True or False? Carcinogens from fried beef and the aflatoxins appear to be the most
important human carcinogens in foods.
5. True or False? Metabolism of a toxic substance always decreases its toxicity.

Fill in the blanks: (1 point each)

1. Tumor cells secrete ___a vascular endothelial growth factor___ (a small
molecule), which promotes blood vessel growth.
2. The blood vessel that transfers substances from the gut to the liver is called the
___hepatic portal vein____.
3. Phase II metabolism increases the water solubility of a substance facilitating its
___excretion___.
4. At the level of neuronal synapses, alcohol enhances the activity of ___GABA
receptors___.
5. Drinking alcohol increases blood ___estrogen___ levels, which in turn augments the
risk of breast cancer. Drinking alcohol also decreases ___folic acid___ levels in cells,
which is important for DNA repair and replication.