CEPHALOSPORIN

are bactericidal and have the same mode of action as other β-lactam antibiotics (such as penicillins), but
are less susceptible to β-lactamases. Cephalosporins disrupt the synthesis of the peptidoglycan layer
forming the bacterial cell wall
Penicillin kills susceptible bacteria by specifically inhibiting the transpeptidase that catalyzes the final step
in cell wall biosynthesis, the cross-linking of peptidoglycan.

First-generation cephalosporins are cefaclor, cefradin, cefadroxil,

cefalexin, cefalotine, and cefazolin.

Second-generation cephalosporins are cefamandole, ceftnetazol,

cefoxitin, and cefuroxime.

Third-generation cephalosporins are cefdinir, cefetamet, cefixime,

cefodizim, cefoperazone, cefotaxime, cefotetan, cefpirome,
cefpodoxime, cefprozil, cefsulodin, ceftazidime, ceftibuten,
ceftizoxime, ceftriaxone, and latamoxef.

Cefipime is a fourth-generation cephalosporin.