According to Torgerson et al.

, asthma is complicated condition that has complex structure

both in environmental and genetic factors. They found out in their study that asthma

vulnerability loci are powerful towards different ancestries, based on the results they have

come up from the sample. Therefore the difference in ancestry plays a big role to the

formation of the complicated hereditary design of asthma.

According to the study of Dannemiller et al., formaldehyde is a colorless gas and has a very

strong odor commonly found inside the house it is used for respiratory carcinogen, irritant,

sensitizer and asthma trigger. The main goal of their research was to come up a measurement

method that is short-term and convenient that can find out the correlation between asthma

control, formaldehyde sources and concentration. They result of their study presents an

uncomplicated technique for calculating formaldehydes at home and it recommends that

exposure to this gas is connected to poorly controlled asthma.

According to Fain et al., that even though multiple detector computed tomography (MDCT)

and hyperpolarized gas magnetic resonance imaging (HP MRI) have exhibits capacity to

detect ventilation and structural abnormalities in asthma but there are studies that wantedt to

validate the regional ideas given by these technniques. The main goal of this research is to

determine regional disease in asthma by assessing the association of areas of ventilation

defect on HP MRI and MDCT and inflammatory indicators on bronchoscopy. The ventilation

obstruction on HP MRI (hyperpolarized gas magnetic resonance imaging ) has a significant

overlap to the hyperlucency of MDCT(multiple detector computed tomography (MDCT)

recommending that the passage of airway barrier and air confining are related in asthma.

According to the study of Robin and Fiese, there is a significant relationship between asthma

severity to the quality of life of a child. Children who have asthma conditions who are not

managed well are like to have an poor quality of life. The study also recommends the need to
use asthma-explicit QOL measures and a source of QOL aside from the informant’s guardian

in order to acquire the exact data of the child’s degree of working.

 References

Torgerson, Dara G., Elizabeth J. Ampleford, Grace Y. Chiu, W. James Gauderman, Christopher R.

Gignoux, Penelope E. Graves, Blanca E. Himes et al. "Meta-analysis of genome-wide association

studies of asthma in ethnically diverse North American populations." Nature genetics 43, no. 9 (2011):

887.

Dannemiller, Karen C., Johnna S. Murphy, Sherry L. Dixon, Kelly G. Pennell, Eric M. Suuberg, David

E. Jacobs, and Megan Sandel. "Formaldehyde concentrations in household air of asthma patients

determined using colorimetric detector tubes." Indoor Air 23, no. 4 (2013): 285-294.

Fain, Sean B., Guillermo Gonzalez-Fernandez, Eric T. Peterson, Michael D. Evans, Ronald L.

Sorkness, Nizar N. Jarjour, William W. Busse, and Janet E. Kuhlman. "Evaluation of structure-function

relationships in asthma using multidetector CT and hyperpolarized He-3 MRI." Academic

radiology 15, no. 6 (2008): 753-762.

Everhart, Robin S., and Barbara H. Fiese. "Asthma severity and child quality of life in pediatric

asthma: a systematic review." Patient education and counseling 75, no. 2 (2009): 162-168.