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Nutritional supplements with demonstrated activity against lymphoma cells include:
Curcumin
Soy extract
Vitamins A, C, D, and E
Green tea
Resveratrol
Ginger
Fish oils
Garlic
  Curcumin, an extract from the spice turmeric, blocks the growth of various types of lymphoma cells,
including Burkitt's lymphoma and EBV B-cell lymphomas (Han SS et al 1999; Ranjan D et al 1999; Wu Y et al
2002b). In addition to arresting the growth of lymphoma cells, curcumin also causes lymphoma cell death by
reducing the levels of some genes (c-myc, bcl-2) and mutant p53 proteins (Han SS et al 1999; Ranjan D et al 1999;
Wu Y et al 2002c). Curcumin has an additional benefit in that it blocks the production of growth factors that cancer
cells require to invade other organs (Dulak J 2005). Clinical studies have shown curcumin supplements to be safe in
doses of up to 3.6 grams a day (Gescher A 2004).
  Genistein, found in soy extracts, induces cell death in lymphoma cells (Baxa DM et al 2003; Buckley
AR et al 1993). It increases the effectiveness of chemotherapy for lymphoma by making cells more susceptible to
agents that cause lymphoma cell death (Mohammad RM et al 2003). Genistein also reduces the ability of cancer cell
spread (angiogenesis) by blocking the production of proteins (angiogenesis growth factors) that cancer cells need to
form new blood vessels (Dulak J 2005).
 Natural and synthetic vitamin A (also known as retinoids) promote normal cell differentiation
and have been used to treat T-cell lymphomas (Kempf W et al 2003; Mahrle G et al 1987; Zhang C et al 2003).
Vitamin D3 blocks the growth of lymphoma cells (Mathiasen IS et al 1993).
   Green tea, which contains epigallocatechin gallate (EGCG), triggers lymphoma cell death (Bertolini F
et al 2000; Katsuno Y et al 2001). In addition, EGCG from green tea reduces the ability of lymphoma cells to invade
other organs by blocking the production of growth factors, such as vascular endothelial growth factor (VEGF) and
the glycoprotein messenger interleukin-8 (IL-8), which lymphoma cells need to spread (Dulak J 2005).
   In experimental studies, vitamin C has improved the effectiveness of chemotherapy in inducing
lymphoma cell death (Chen Q et al 2005; Nagy B et al 2003; Prasad SB et al 1992). Vitamin E supplements boost
the function of immune cells capable of killing lymphoma cells (Ashfaq MK et al 2000; Dalen H et al 2003b;
Dasgupta J et al 1993). Alpha-tocopheryl succinate, a semisynthetic analogue of vitamin E, is a potential adjuvant in
cancer treatment (Dalen H et al 2003a).
 ! " Resveratrol, a naturally occurring substance found in grapes, blocks the growth of lymphoma cells and
also increases their rate of cell death (Bruno R et al 2003; Park JW et al 2001). Resveratrol sensitizes chemotherapy-
resistant lymphoma cells to treatment with paclitaxel-based chemotherapy (Jazirehi AR et al 2004). Resveratrol also
reduces the production of growth factors such as VEGF and IL-8, and theoretically should be beneficial in reducing
the ability of lymphoma cells to spread to other organs (Dulak J 2005).
#  Extracts from ginger, known as galanals A and B, induce cell death in human lymphoma cells (Miyoshi N
et al 2003).
$%" Eicosapentaenoic acid (EPA) found in fish oil induces cell death in lymphoma cells (Heimli H et al 2001,
2002, 2003). Omega-3 fatty acids in fish oil normalized elevated blood lactic acid in a dose-dependent manner,
increasing disease-free survival and survival time for dogs with Stage III lymphoma (Ogilvie GK et al 2000).
"Garlic extracts can induce death in lymphoma cells (Arditti FD et al 2005; Scharfenberg K et al 1990).
Indeed, in a recent study, conjugation of a garlic extract to the antibody rituximab (which targets lymphoma cells)
led to the death of these cells (Arditti FD et al 2005).

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