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PROSPERO

International prospective register of systematic reviews

Treatment of cervical cancer in HIV-seropositive women from developing countries: a


systematic review
WITNESS MAPANGA, Brendan Girdler-Brown, Elvira Singh, Tsungai Chipato

Citation
WITNESS MAPANGA, Brendan Girdler-Brown, Elvira Singh, Tsungai Chipato. Treatment of
cervical cancer in HIV-seropositive women from developing countries: a systematic review.
PROSPERO 2018 CRD42018095707 Available from:
http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018095707

Review question
What are the treatment modalities that are being used to treat cervical cancer in HIV-seropositive women in
developing countries?

Searches
The search strategy of the online databases will be based on the criteria developed in the previous review
protocol by
Mapanga and colleagues. MEDLINE (1966–present) and Embase (1980–present) will be searched via the
OVID
interface. In addition, PubMed, Cochrane and CINAHL (1961–present) will be searched using a combination
of the following keywords: cervical cancer, treatment, developing countries (the geographical search concept
will be extended to include country names of developing countries), invasive cervical cancer,
HIV, management of cervical cancer, chemotherapy, surgery and radiation. In addition, health databases
which cover developing countries (3ie Systematic Reviews, WHO library and databases, World Bank
website) and databases and websites containing on-going research (such as WHO ICTRP
and ClinicalTrials.gov) will also be searched for relevant literature. Proximity operators, Boolean logic
operators and truncation commands will be used as suggested in the previous review protocol as well
as conducting preliminary search trials. To search for additional and relevant papers, reference and
citation tracking will be conducted

Types of study to be included


Prospective and retrospective cohort studies, case-control, randomised controlled trials and cross-sectional
studies that were carried out in and for the developing world will be eligible for inclusion

Condition or domain being studied


Cervical cancer treatment in HIV-seropositive women

Participants/population
HIV-seropositive women

Intervention(s), exposure(s)
Cervical cancer treatment modalities such as chemotherapy, surgery etc

Comparator(s)/control
None

Context
Developing/ low-income countries

Primary outcome(s)
Existing treatment methods being used to treat cervical cancer in HIV-seropositive women in developing

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PROSPERO
International prospective register of systematic reviews

countries

Secondary outcome(s)
Existing treatment modalities that are affordable and feasible for developing countries

Data extraction (selection and coding)


The data extraction process and choice of indicators to be extracted from the included studies will be guided
by
the process indicated in the previous review. There will be double data extraction by WM, TC, BGB and ES
and
the team will solve disagreements and discrepancies through discussions.

Risk of bias (quality) assessment


The assessment of the quality of included studies will be guided by a modified version of the Newcastle-
Ottawa
Quality Assessment Scale. All included studies will be assessed based on their study design that was used
to measure cervical cancer treatment, validity of key findings (if study is describing cervical cancer treatment
methods or a comparison of treatment methods), follow-up period and sample representativeness.

Strategy for data synthesis


Results of this review will be synthesised using both the narrative synthesis and meta-analysis as described
in the
planned review. Narrative synthesis will be used for descriptive analysis whilst random-effects aggregate
data
meta-analysis will be used to combine all numerical findings from the included studies. Assessment of bias
will also be analysed using the meta-analysis and funnel plots will be produced using the RevMan software
and
statistical significance at 95% using t test will be inferred. Higgins and Thompson’s I² statistic is going to be
used
to assess heterogeneity, where a 0% will indicate no heterogeneity and increase in percentage will
indicate increase in heterogeneity

Analysis of subgroups or subsets


If included studies have sufficient details to extract data of participants’ ages or duration of HIV infection,
then subgroup analysis to answer specific questions about different participants’ groups will be performed.
Estimates during analysis will be presented in forest plots and tables.

Contact details for further information


WITNESS MAPANGA
witnessmapanga@yahoo.co.uk

Organisational affiliation of the review


School of Health Systems and Public Health, Epidemiology & Biostatistics, University of Pretoria

Review team members and their organisational affiliations


Mr WITNESS MAPANGA. School of Health Systems and Public Health, Epidemiology & Biostatistics,
University of Pretoria
Professor Brendan Girdler-Brown. School of Health Systems and Public Health, Epidemiology &
Biostatistics, University of Pretoria
Dr Elvira Singh. South Africa National Cancer Registry
Professor Tsungai Chipato. Department of Obstetrics and Gynaecology, University of Zimbabwe

Anticipated or actual start date


18 July 2017

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PROSPERO
International prospective register of systematic reviews

Anticipated completion date


31 August 2018

Funding sources/sponsors
This review is part of Witness' PhD degree

Conflicts of interest
Language
(there is not an English language summary)

Country
South Africa, Zimbabwe

Published protocol
https://www.crd.york.ac.uk/PROSPEROFILES/95707_PROTOCOL_20180504.pdf

Stage of review
Review_Ongoing

Subject index terms status


Subject indexing assigned by CRD

Subject index terms


Cervical Intraepithelial Neoplasia; Developing Countries; Female; HIV Seropositivity; Humans; Uterine
Cervical Neoplasms

Date of registration in PROSPERO


25 May 2018

Date of publication of this version


25 May 2018

Details of any existing review of the same topic by the same authors
Stage of review at time of this submission

Stage Started Completed


Preliminary searches Yes Yes
Piloting of the study selection process Yes Yes

Formal screening of search results against eligibility criteria Yes Yes

Data extraction No No
Risk of bias (quality) assessment No No

Data analysis No No

Versions
25 May 2018

PROSPERO
This information has been provided by the named contact for this review. CRD has accepted this information in good

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PROSPERO
International prospective register of systematic reviews

faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration
record, any associated files or external websites.

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