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Abstract
Nowadays, alternative medicines have become a multibillion-dollar industry and continue
growing. Herbal medicine is one of the primeval forms of medicine which is prepared
exclusively from herbal plants. The Ayurvedic medicinal cure method is also been used as a
prescription for chronic diseases such as cancer, asthma, diabetes, and end-stage renal
diseases and increasing interest in European countries respectively. According to the report
of world health organization (WHO), 4 billion people (80% of the world's population) use
herbal medicines for some perspective of primary healthcare; approximately 25% of modern
drugs used in the United States have been procured from plants. It is estimated that 11% of
the total 252 medicinal drugs found in crucial medicine list of WHO are particularly of plant
origin. The purpose of this study is to find out the toxic and beneficial effects of medicinal
herbs on renal health by which evidence for benefit or toxicity has been found. The review
aims to provide knowledge and guide to encourage future toxicity studies on the kidney by
medicinal herbs.
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 28
Nephrotoxic Effect of Herbal Medicine Maurya Neelesh Kumar
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 29
Research & Reviews: A Journal of Toxicology
Volume 9, Issue 2
ISSN: 2231-3834 (Online), ISSN: 2349-1264 (Print)
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 30
Nephrotoxic Effect of Herbal Medicine Maurya Neelesh Kumar
Cape aloes is an Aloe ferox Mill (A. like activity effect is a common habit of East
candelabrum A. Berger) African people. Catha edulishas a side effect on
Typically perceived as the harsh aloe or Cape a number of gastrointestinal tract problems,
aloe, it is a polymorphic species local to South oesophagitis, and gastritis and delayed intestinal
Africa. Cape aloes have been utilized since absorption, as well as the development of oral
antiquated occasions as a conventional chemo keratotic white lesions at the site of chewing.
preventive and hostile to tumour cure in Above herb has potential effect of diuretic and
society prescription and it has a well-perceived its use needs cautions in a healthy individual
history of utilization as a diuretic. person as well as the renal compromised
Notwithstanding the plenty of customary patient. A portion of these herbs is used as
therapeutic uses, A. forex optional metabolite aggravations to the cylindrical cell while some
mixes in aloe have been locked in to cause may modify serum electrolytes. Juniper berries
parenchymatous nephritis and examination have terpene that is associated with one of the
studies have uncovered renal harm by causing risks of kidney disturbance and harm in excess
intense cylindrical corruption, recommending [29]. In Germany, parsley and goldenrod are
that renal damage is expected to cause shown for the fundamental water system of the
dehydration [26]. urinary tract furthermore, for avoiding kidney
stones. The diuretic impact of parsley leaf and
Violet Tree, Wild Wisteria (Securidaca root is because of its unstable oil (apiole and
longepedunculata) myristicin) parts. Natural medicine items may
It is a savannah bush, most of the time utilized contain substantial metals. It is a broadly known
by conventional botanists. The home-grown with certainty and that numerous home-grown
remedy of the violet tree is generally utilized medicines, especially Ayurvedic home-grown
for the treatment of dysmenorrhoea, venereal arrangements contain nephrotoxic
sicknesses just as an expectorant and overwhelming metals viz. lead, mercury,
abortifacient. Violet tree root has natural cadmium what's more, arsenic. Some heavy
secondary metabolite methyl salicylate and metals are considered to have therapeutic
saponins which has observed potential effects in the CAM specialities and the problem
nephrotoxic in various scientific studies. lies in the fact that their concentration is not
Kidney histology of treated rats showed standardised and there is unpredictability batch
characteristics consistent with renal epithelial to batch. The nearness of substantial metals and
injury from toxins [27]. their fixations are ordinarily not uncovered on
the marks of home-grown drugs. Natural
African Mango (Irvingia gabonensis) prescriptions are containing different
It is a neighbourhood leaf plant developed in medications. It has been perceived that
tropical woods in West Africa. It is widely numerous home-grown details contain non-
utilized in West African cooking and created steroidal mitigating prescriptions which restrain
industrially. This plant remedy is very valuable renal vasodilator prostaglandins and can prompt
in weight decrease, skin illness, controlling renal disappointment. Natural medications are
diabetes, hypolipidemic impact and so on. After having a high substance of oxalic acid [30].
long haul expending this herb, the patient has Rhubarb, this is a common herbal preparation
answered to grow quickly advancing but has high oxalate content and can promote
unfavourable effect on renal disappointment, the formation of renal calculi. Star fruit
hepatic, heart after utilization of home-grown ingestion has been reported to produce acute
arrangements from this plant [28]. oxalate. Are some herbs nephroprotective also?
Silymarin derived from milk thistle (Silybum
Khat Leaf (Catha edulis) marianum) seeds contains several potent
Catha edulis Forsk is a little to medium antioxidant flavonolignans [31].
measured green tree refined by and large in
Eastern and Horn of Africa. Chewing Khat leaf Edible plants that have been associated with
for its psychostimulatory and antidepressant- chronic kidney injury are given in the Table 1.
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 31
Research & Reviews: A Journal of Toxicology
Volume 9, Issue 2
ISSN: 2231-3834 (Online), ISSN: 2349-1264 (Print)
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 32
Nephrotoxic Effect of Herbal Medicine Maurya Neelesh Kumar
RRJoT (2019) 28-35 © STM Journals 2019. All Rights Reserved Page 33
Research & Reviews: A Journal of Toxicology
Volume 9, Issue 2
ISSN: 2231-3834 (Online), ISSN: 2349-1264 (Print)
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In vivo Cough Suppressive Activity of
Pectic Polysaccharide with Cite this Article
Arabinogalactan Type II Side Chains of Neelesh Kumar Maurya. Nephrotoxic
Piper nigrum Fruits and Its Synergistic Effect of Herbal Medicine and
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Silymarin attenuates ELMO-1 and KIM-1
Expression and Oxidative Stress in the
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