Review CD4

Sel CD4 memiliki cangkupan peranan yang luas dalam respon imun, salah satunya berperan dalam
deferensiasi sel menjadi subline yang dapat menginduksi sistem imun yang bersifat destruktif bagi sel
kanker. Sel T CD4 menunjukkan potensi yang diduga dapat diaplikasikan secara efektif untuk penanganan
kanker (Kim and Cantor, 2014).

Pada penelitian Kang et al., (2011)

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R,
Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M,
Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L.2011.Senescence
surveillance of premalignant hepatocytes limits liver cancer development. Nature 479:547–551
Kim, H.-J., & Cantor, H. 2014. CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful.
Cancer Immunology Research, 2(2), 91–98. doi:10.1158/2326-6066.cir-13-0216 Kim, H.-J., & Cantor,
H. (2014). CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful. Cancer
Immunology Research, 2(2), 91–98. doi:10.1158/2326-6066.cir-13-0216
In this study of Kang et al., antigen-specific CD4 T cells
showing a Th1-phenotype were detected that were directed
against oncogenic ras-expressing pre-malignant hepatocytes.
Senescence surveillance is restricted to the pre-malignant
state and requires macrophages and CD4 T cells. Interestingly,
it has been shown that CD8 T cells are not required
in this mechanism as long as the pre-malignant cell can be
identified by SASP. If senescence is no longer maintained
due to the accumulation of additional genetic alterations,
such as loss of p53-function, the cell finally becomes malignant,
loses its SASP and is no longer recognized by senescence
surveillance. At this point, CD8 T lymphocytes start
to play a crucial role in mediating tumor growth control [