204 Chapter 5 Pharmacopoeia

Glyceryl $ Trinitrate nitrate. See GTN.

GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.
204 Chapter 5 Pharmacopoeia
Glyceryl $ Trinitrate nitrate. See GTN.
GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.
204 Chapter 5 Pharmacopoeia
Glyceryl $ Trinitrate nitrate. See GTN.
GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.

204 Chapter 5 Pharmacopoeia

Glyceryl $ Trinitrate nitrate. See GTN.
GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.
204 Chapter 5 Pharmacopoeia
Glyceryl $ Trinitrate nitrate. See GTN.
GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.
204 Chapter 5 Pharmacopoeia
Glyceryl $ Trinitrate nitrate. See GTN.
GTN sublingual/ transdermal $ Nitrate. Dose 1� 2 sprays/ PRN
SL; 0.3� 1mg/ PRN SL Indication Prophylaxis and treatment of angina, left
ventricular failure CI Hypotensive conditions, hypovolaemia, aortic stenosis
Caution Pregnancy, breastfeeding, hypothyroidism, recent MI, head
trauma SE Postural hypotension, tachycardia, headache Info Transdermal
patches are available, see BNF� patients may develop tolerance (tachyphylaxis)
to nitrates and as such it is suggested to ensure patients have a
nitrate- free period for 4� 8h to prevent this; it is usual to have this period
overnight when the effects of nitrates are least likely to be needed.
GTN IV infusion $ Nitrate. Dose 10� 200micrograms/ min IVI GTN.
For typical prescription see Fig. 5.2. Indication Left ventricular failure, ongoing
ischaemic chest pain refractory to SL nitrates CI Hypotensive conditions,
hypovolaemia, aortic stenosis Caution Pregnancy, breastfeeding,
hypothyroidism, recent MI, head trauma SE Postural hypotension, tachycardia,
headache Info Patients may develop tolerance (tachyphylaxis) to
nitrates and as such it is suggested to ensure patients have a nitrate- free
period for 4� 8h to prevent this; it is usual to have this period overnight
when the effects of nitrates are least likely to be needed.