Académique Documents
Professionnel Documents
Culture Documents
1% Solute
{Na, K, Ca, Mg,
99 % Aq liquid Mucin, Albumin,
Enzymes(Amylas
e, lipase) }
• • Gels • Sprays
Tablets
• Patches/films • Ointments
• Wafers
• Lozenges
• Powders
Preferred Drug
Candidate
Diluents Plasticizer
Weight Variation Y Y
Assay Y Y Y Y
Thickness Y Y
Friability Y
Disintegration time Y Y
Residence time Y Y Y
Tensile strength Y
Folding endurance Y
Viscosity Y
Droplets size Y
Dissolution Y Y Y
Mucoadhesion Y Y Y
Strength
Permeability test Y Y Y
Department of Pharmaceutical Technology, Y
4/10/2013 LJ Institute of Pharmacy, Ahmedabad 35
Some important in-vitro test
Disintegration time:
Slide frame method: film on slide + drop of water in it.
Note the time when hole is observed in the film.
Petri dish method: film in Petri plate + 2 ml of water in it.
Check time till film dissolves.
Residence time:
Take a slide, stick a mucosa on it with gum. Place
our dosage form on it with few droplets of PBS 6.8,
allow it to stick on it. Now make it inclined at 30 C
& at constant rate add PBS 6.8 drop wise on it
without moving the slide. Note the time till dosage
form detaches from mucosa.
• Limitation:
softens on extended period and
lose its shape which hinders the control of
disintegration over long time periods
Buccal Methyltestosterone
Brand name-Metandren, Ciba;
Avoids first-pass hepatic metabolism
Prochlorperazine
Brand name -Oreton ,Schering Buccastem,
Alternative to enteral tablet