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Hypertension affects one-third of Americans and is a significant modifiable risk factor for cardiovascular disease,
stroke, renal disease, and death. Severe asymptomatic hypertension is defined as severely elevated blood pressure
(180 mm Hg or more systolic, or 110 mm Hg or more diastolic) without symptoms of acute target organ injury. The
short-term risks of acute target organ injury and major adverse car-
diovascular events are low in this population, whereas hyperten-
sive emergencies manifest as acute target organ injury requiring
immediate hospitalization. Individuals with severe asymptomatic
hypertension often have preexisting poorly controlled hypertension
and usually can be managed in the outpatient setting. Immediate
diagnostic testing rarely alters short-term management, and blood
pressure control is best achieved with initiation or adjustment of anti-
hypertensive therapy. Aggressive lowering of blood pressure should
be avoided, and the use of parenteral medications is not indicated.
H
CME This clinical content ypertension affects more than renal injury, or aortic dissection.7 These
conforms to AAFP criteria 30% of adults in the United patients require urgent evaluation and
for continuing medical
education (CME). See
States and is a significant hospitalization.
CME Quiz Questions on modifiable risk factor for car- A retrospective cohort study from a single
page 483. diovascular disease, stroke, renal disease, multispecialty outpatient health care system
Author disclosure: No rel- and death.1,2 Several high-quality studies showed that in 4.6% of patients, initial blood
evant financial affiliations. have shown that treatment of hypertension pressure measurements met diagnostic cri-
reduces long-term hypertension-related teria for severe asymptomatic hypertension.8
adverse outcomes and all-cause mortality.3-5 Approximately 4% of emergency department
Severe asymptomatic hypertension, or (ED) visits are for the management of severe
hypertensive urgency, is defined as severely asymptomatic hypertension,9,10 and more
elevated blood pressure (180 mm Hg or than 4.5% of adult inpatients receive intra-
more systolic, or 110 mm Hg or more dia- venous antihypertensive medications for
stolic) without acute target organ injury.6 management of blood pressure elevations.11
Patients may still have headache, lighthead- Severe asymptomatic hypertension most
edness, nausea, shortness of breath, palpi- often occurs in patients previously diag-
tations, epistaxis, or anxiety, depending on nosed with hypertension. More than 60%
the acuity and severity of blood pressure of patients have persistent uncontrolled
elevation. hypertension six months after a documented
Hypertensive emergency is defined as clinic visit with a systolic blood pressure of
severe blood pressure elevation in the pres- 180 mm Hg or more, or a diastolic blood
ence of acute target organ injury, such as pressure of 110 mm Hg or more.8 Medication
encephalopathy, cerebrovascular or car- noncompliance has been reported in up to
diovascular events, pulmonary edema, 65% of patients prescribed antihypertensive
492 American
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Severe Asymptomatic Hypertension
Evidence
Clinical recommendation rating References
Patients with severely elevated blood pressure should have a history and C 6, 10, 13
physical examination to distinguish between severe asymptomatic
hypertension and hypertensive emergency.
A 30-minute rest period is recommended when the initial blood pressure C 15
reading is severely elevated. In more than 30% of patients, the blood pressure
will lower to an acceptable level without intervention following the rest period.
An immediate diagnostic evaluation is not required in the initial management of C 8, 17, 18
severe asymptomatic hypertension.
Aggressive lowering of blood pressure can be harmful and should be avoided C 10, 21
in patients with severe asymptomatic hypertension. Gradual reduction over
several days to weeks is recommended.
medications and is a major cause of severe Physical examination findings are often
asymptomatic hypertension.12 In rare cases, normal in patients with severe asymp-
unrecognized secondary hypertension (e.g., tomatic hypertension. However, attention
renal vascular hypertension; sympathetic should be directed toward signs of target
crisis from cocaine toxicity, pheochromocy- organ injury. These signs can be neurologic
toma, or acute alcohol withdrawal; primary (motor or sensory deficits), ophthalmologic
hyperaldosteronism) can present with severe (arteriolar narrowing, hemorrhage, papill-
blood pressure elevations.7 edema), cardiovascular (arrhythmia, dis-
There is insufficient evidence to dictate placed point of maximal impulse, murmur,
the most appropriate management for severe third heart sound gallop), pulmonary (rales,
asymptomatic hypertension. Most guide- hypoxia, tachypnea), or vascular (dimin-
lines focus on hypertensive emergency. ished or absent peripheral pulses, abdomi-
nal bruits, unequal pulses or blood pressure,
Evaluation jugular venous distension).4,10,13 Clinical
HISTORY AND PHYSICAL EXAMINATION examination findings that suggest acute tar-
A comprehensive history is essential in the get organ injury (new or evolving neurologic
initial evaluation of patients with severe deficits, papilledema, pulmonary edema) are
asymptomatic hypertension (Table 1).6 regarded as a hypertensive emergency until
A medication history should include any proven otherwise.
new medications; illicit substances (e.g.,
sympathomimetics, cocaine); and, most
importantly, compliance with current pre- WHAT IS NEW ON THIS TOPIC: SEVERE ASYMPTOMATIC
scriptions.13 A targeted symptom history HYPERTENSION
should be obtained to identify a potential
The U.S. Preventive Services Task Force recommends out-of-office blood
hypertensive emergency. Severe blood pres- pressure monitoring (using home and ambulatory blood pressure monitoring
sure elevations may cause mild symptoms devices) as an important adjunct to in-office measurements for diagnosing
(e.g., headache, lightheadedness, nausea, hypertension.
shortness of breath, palpitations, epistaxis, A recent trial of an outpatient population referred to the emergency
anxiety) without acute target organ injury, department for severe asymptomatic hypertension showed that only 5%
of tests ordered had abnormal results, and 2% of patients had evidence
although patients with chest pain should of target organ injury. Less than 1% of patients had a major adverse
receive appropriate evaluation for chest pain, cardiovascular event within six months.
not severe asymptomatic hypertension.
April 15, 2017 ◆ Volume 95, Number 8 www.aafp.org/afp American Family Physician 493
Severe Asymptomatic Hypertension
Proper technique should be used for all pressure lowers to an acceptable level (mean
blood pressure measurements 6,10,14 (Table 2 14). of 160/89 mm Hg) without intervention fol-
If the blood pressure measurement is severely lowing a 30-minute rest period.15
elevated, the patient should be allowed to qui-
HOME AND AMBULATORY BLOOD PRESSURE
etly rest. In more than 30% of patients with
MONITORING
severe asymptomatic hypertension, blood
The U.S. Preventive Services Task Force rec-
ommends out-of-office blood pressure mon-
itoring (using home and ambulatory blood
Table 1. Medical History in the Evaluation of Severe pressure monitoring devices) as an impor-
Asymptomatic Hypertension
tant adjunct to in-office measurements for
diagnosing hypertension.16 A major advan-
Previous hypertension (duration and levels)
tage of out-of-office monitoring is the abil-
Personal history: coronary artery disease, congestive heart failure,
cerebrovascular disease, chronic kidney disease, peripheral vascular disease, ity to obtain multiple readings over time.
diabetes mellitus, sleep apnea Specific indications for out-of-office moni-
Risk factors: family history of hypertension, hyperlipidemia, diabetes, tobacco toring in the setting of severe asymptomatic
use, dietary habits, weight gain, sedentary lifestyle hypertension include suspected white coat
Secondary causes: family history of kidney disease, personal history of renal hypertension (isolated clinic hypertension)
disease, medications and illicit drug use, clinical features of metabolic
disorders (e.g., thyroid disease, pheochromocytoma, hyperaldosteronism)
and highly variable in-office blood pressure
Target organ injury: neurologic (headache, vision changes, seizure, neurologic readings. Additionally, out-of-office moni-
deficits), cardiovascular (chest pain, shortness of breath, myocardial toring is useful to assess compliance with
infarction, syncope, history of palpitations or arrhythmias), renal (oliguria, antihypertensive therapy.
anuria), peripheral arteries (claudication, cold extremities, weak distal pulses),
pulmonary (sleep apnea, chronic lung disease) DIAGNOSTIC EVALUATION
Concurrent medication/drug use: nonsteroidal anti-inflammatory drugs,
antidepressants, oral contraceptives, cold medications, sympathomimetics Patients presenting with severe asymptomatic
(amphetamines, cocaine, phencyclidine), corticosteroids, herbal remedies hypertension rarely require diagnostic evalu-
Compliance with antihypertensive therapy ation, although subsequent office visits should
include evaluation for long-term hyperten-
Information from reference 6.
sion risks based on current guidelines.4,6
Patients with symptoms or clinical findings
suggesting acute target organ injury require
appropriate diagnostic testing and evaluation
Table 2. Proper Technique for Blood Pressure Measurements for possible hypertensive emergency. A recent
trial of an outpatient population referred to
An appropriately sized automated electronic arm cuff device should be used.
the ED for severe asymptomatic hypertension
Initially, a measurement should be obtained in both arms, and the higher blood
pressure should be used (significant differences between arms occur in aortic
showed only 5% of tests ordered had abnormal
coarctation, subclavian artery stenosis). results, and only 2% of patients had evidence
The patient should have an empty bladder and remain seated with legs of target organ injury. The most commonly
uncrossed for five minutes before the measurement. ordered tests were basic or complete meta-
The measurement should occur at the level of the heart with the arm resting bolic panel (64% of patients; abnormal in
on a table. five out of 247 patients), urinalysis (30% of
Postural blood pressure should be obtained in older adults.
patients; abnormal in 20 out of 115 patients),
A minimum of two readings should be obtained one to two minutes apart and
averaged.
cardiac enzymes (35% of patients; abnormal
The diagnosis of hypertension should be confirmed at a subsequent visit unless
in two out of 137 patients), chest radiography
the blood pressure reading is very high or the patient is symptomatic. (35% of patients; abnormal in five out of 137
Evaluation of white coat hypertension (elevated clinic blood pressure and patients), and computed tomography of the
normal ambulatory blood pressure) and masked hypertension (normal head (13% of patients; no abnormalities).
clinic blood pressure and elevated ambulatory blood pressure) should be Electrocardiography was performed in less
considered as clinically indicated.
than 1% of patients.8
Information from reference 14. A cross-sectional study of two urban EDs
enrolled 167 asymptomatic patients with triage
494 American Family Physician www.aafp.org/afp Volume 95, Number 8 ◆ April 15, 2017
Severe Asymptomatic Hypertension
diastolic blood pressure of 100 mm Hg or Patients who were sent home had a lower rate
more. A basic metabolic panel was performed of subsequent hospital admission at seven
for all patients, of which 12 (7%) had unan- days and at eight to 30 days compared with
ticipated abnormalities resulting in hospi- those originally sent to the hospital. Less
talization, primarily for renal dysfunction.17 than 1% of patients were referred to the hos-
The American College of Emergency Physi- pital, validating that outpatient management
cians does not recommend routine laboratory is an appropriate, cost-effective approach. A
testing in patients with severe asymptomatic limitation of this study is that 20% of patients
hypertension.18 No other organization or pol- were lost to follow-up, and their outcomes were
icy guideline has provided recommendations not included in the analysis.8
to assist in the diagnostic evaluation. Without A prospective observational study (n = 146)
sufficient clinical evidence, diagnostic evalua- investigated the risk of short-term adverse
tion for severe asymptomatic hypertension is effects of severe asymptomatic hypertension
largely anecdotal. (mean blood pressure of 217/112 mm Hg at
presentation) following discharge from the
Treatment ED. Antihypertensive treatment was given
There are currently no validated policies or to 90% of patients in the ED, and 92% were
nationally recognized clinical guidelines to discharged with prescriptions (80% got pre-
assist in the management of severe asymp- scriptions for two medications). More than
tomatic hypertension. A suggested approach 35% of patients still had blood pressure of
is shown in Figure 1. When managing severe more than 190/100 mm Hg at discharge,
asymptomatic hypertension, several impor- regardless of whether they were treated or
tant key questions should be considered. observed in the ED. At the 10-day follow-up,
the mean blood pressure significantly
DOES ACUTE MEDICAL MANAGEMENT AFFECT improved (160/90 mm Hg) with no serious
SHORT-TERM ADVERSE OUTCOMES?
adverse outcomes. The authors concluded
Serious adverse events related to poorly con- that attempts to lower blood pressure acutely
trolled hypertension (e.g., death, acute renal may not be necessary. Discharging patients
injury, cardiovascular complications, rup- with antihypertensive medications is a rea-
tured aortic aneurysms) are rare even when sonable and safe option.20
follow-up is delayed for several months.19 Despite the lack of evidence of an imme-
A retrospective outpatient study (n = diate increase in risk of major adverse car-
58,535) evaluated the short-term outcomes diovascular events, primary care physicians
of patients with severe asymptomatic hyper- often are hesitant to send patients with severe
tension. Patients had a mean systolic blood blood pressure elevations home. As a result,
pressure of 183 mm Hg (10% of patients had it remains common practice to acutely lower
a measurement greater than 200 mm Hg) blood pressure using short-acting antihy-
and mean diastolic blood pressure of 96 mm pertensives. Patients with symptoms such
Hg (6% of patients had a measurement of as headache, lightheadedness, shortness of
120 mm Hg or more). From the outpatient breath, epistaxis, or anxiety are more likely
clinic, 426 patients (0.7%) were referred to to benefit from these agents.14,15,21 When
the hospital (387 went to the ED, and 39 were blood pressure improves, long-acting anti-
directly admitted) for blood pressure man- hypertensive therapy should be initiated,
agement. The remainder of patients were sent restarted, or adjusted.22 Table 3 includes
home. Outcomes measured were the rate of selected oral antihypertensives for the treat-
major adverse cardiovascular events within ment of severe asymptomatic hypertension.
seven days, eight to 30 days, and six months.
HOW QUICKLY SHOULD BLOOD PRESSURE
The overall rate of major adverse cardiovas-
BE LOWERED?
cular events in both groups was low (less
than 1%) with no significant differences at In the absence of acute target organ injury,
seven days, eight to 30 days, and six months. blood pressure should be lowered gradually
April 15, 2017 ◆ Volume 95, Number 8 www.aafp.org/afp American Family Physician 495
Severe Asymptomatic Hypertension
Signs or symptoms of
acute target organ injury?†
Yes No
Obtain history
Abnormal physical
examination findings?‡
Yes No
Hospitalize for
hypertensive
emergency
Asymptomatic Mild symptoms§
Previous hypertension?
Administer short-
acting antihyper
Yes No tensive medication
Follow up in
2 to 4 weeks Follow up in
2 to 4 weeks Yes No
Follow up in 1 week
Acute target organ injury?
Yes No
Follow up in 1 week
496 American Family Physician www.aafp.org/afp Volume 95, Number 8 ◆ April 15, 2017
Severe Asymptomatic Hypertension
Beta blockers
Atenolol 25 to 50 mg once per day Avoid in patients with bradycardia; may cause
Metoprolol succinate 25 to 100 mg once per day bronchospasm
(Toprol XL)
Diuretic
Hydrochlorothiazide 12.5 to 25 mg once per day Use with caution in patients with gout; may cause
hypokalemia and hyponatremia
Beta blocker
Labetalol 100 mg twice per day May cause orthostatic hypotension and nausea
to less than 160/100 mm Hg, but not acutely achieve target blood pressure goals.23 Aggres-
by more than 20% to 25% of the mean sive blood pressure lowering in patients with
arterial blood pressure over several days to severe asymptomatic hypertension can lead
weeks.21 Every two to four weeks, antihyper- to adverse events, such as myocardial infarc-
tensive intensification is recommended to tion, cerebrovascular accident, or syncope.
April 15, 2017 ◆ Volume 95, Number 8 www.aafp.org/afp American Family Physician 497
Severe Asymptomatic Hypertension
Parenteral medication is not indicated and or calcium channel blockers are recom-
should be reserved for the management of mended. In patients with chronic kidney
hypertensive emergencies.13 disease, an angiotensin-converting enzyme
Patients who have not been compliant inhibitor or angiotensin receptor blocker
often can safely resume their outpatient med- improves renal outcomes.24 Additionally, a
ications.10 Dosing adjustments and additions patient’s preexisting comorbid conditions
are recommended for those already on anti- may dictate the preference of antihyperten-
hypertensive therapy. No specific medication sive class 6,25 (Table 4 6). Severe asymptomatic
classes are recommended for the initial man- hypertension generally requires two-drug
agement of severe asymptomatic hyperten- therapy, and several meta-analyses clearly
sion. The Eighth Joint National Committee show superior blood pressure reduction with
Report on Prevention, Detection, Evaluation, combination therapy vs. monotherapy.26
and Treatment of Hypertension (JNC 8) rec-
WHO SHOULD BE HOSPITALIZED?
ommendations for the treatment of essential
hypertension, which are based on quality Hospitalization is rarely required for patients
randomized controlled trials, should be con- with severe asymptomatic hypertension.
sidered when initiating long-term therapy for However, those with escalating blood pres-
severe asymptomatic hypertension. sure measurements, progressive symptoms
In the general nonblack population, of target organ injury, or evolving clinical
thiazide-type diuretics, calcium channel evidence of acute target organ injury should
blockers, angiotensin-converting enzyme be hospitalized.
inhibitors, or angiotensin receptor blockers There are no published data to determine
are recommended for initial treatment. In what blood pressure measurement is too high.
the black population, thiazide-type diuretics A Veterans Administration Cooperative trial
from 1967 followed patients with diastolic
blood pressure averaging between 115 and
Table 4. Medication Preferences for Severe Asymptomatic 129 mm Hg. No patients had a major adverse
Hypertension Based on Known Preexisting Factors cardiovascular event within two months of
enrollment.19 Although scientific evidence
Condition Preferred medication class
is lacking, patients with sustained diastolic
Angina pectoris Beta blockers, calcium channel blockers blood pressure of 130 mm Hg or more should
Aortic aneurysm Beta blockers be considered for treatment with short-acting
Asian or black race Diuretics, calcium channel blockers antihypertensives followed by long-acting
Atrial fibrillation Beta blockers, calcium channel blockers agents. Symptomatic patients with persistent
(nondihydropyridine) systolic blood pressure elevations exceed-
Cerebrovascular accident All classes ing 240 mm Hg or diastolic blood pressure
Chronic obstructive All classes except beta blockers greater than 130 mm Hg despite appropriate
pulmonary disease
rest and treatment with short-acting antihy-
Congestive heart failure Diuretics, beta blockers, ACE inhibitors, ARBs,
mineralocorticoid receptor antagonists pertensives may benefit from hospitalization.
Diabetes mellitus ACE inhibitors, ARBs
HOW SHOULD HOSPITALIZED PATIENTS WITH
Left ventricular hypertrophy ACE inhibitors, ARBs, calcium channel SEVERE ASYMPTOMATIC HYPERTENSION BE
blockers
MANAGED?
Myocardial infarction Beta blockers, ACE inhibitors, ARBs
Peripheral vascular disease ACE inhibitors, calcium channel blockers Inpatient treatment of acute hypertension
Stable chronic kidney disease ACE inhibitors, ARBs is often aggressive, and intravenous antihy-
pertensives are commonly used when blood
ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker.
pressure readings are only modestly elevated
Adapted with permission from Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/
(151 to 170/101 to 110 mm Hg). However,
ESC guidelines for the management of arterial hypertension: the Task Force for the
Management of Arterial Hypertension of the European Society of Hypertension (ESH) there is no evidence that acute inpatient
and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34(28):2190. treatment of severe asymptomatic hyper-
tension improves outcomes, and one study
498 American Family Physician www.aafp.org/afp Volume 95, Number 8 ◆ April 15, 2017
Severe Asymptomatic Hypertension
demonstrated increased hospital stays when Statistics Subcommittee. Heart disease and stroke sta-
tistics—2014 update:a report from the American Heart
intravenous antihypertensives were used.11 Association. Circulation. 2014;129(3):e28-e292.
Blood pressure elevations during hospital- 2. Centers for Disease Control and Prevention. Vital signs:
ization are often exacerbated by pain, anxiety, awareness and treatment of uncontrolled hyperten-
or acute illness. When these factors have been sion among adults—United States, 2003-2010. MMWR
Morb Mortal Wkly Rep. 2012;61:703-709.
excluded and the patient remains hyperten- 3. Wright JT Jr, Williamson JD, Whelton PK, et al.;SPRINT
sive, it is best practice to reinitiate or adjust Research Group. A randomized trial of intensive versus
oral antihypertensive therapy in those with standard blood-pressure control. N Engl J Med. 2015;
373(22):2103-2116.
preexisting hypertension. In patients without
4. Chobanian AV, Bakris GL, Black HR, et al.;National
previous hypertension, oral antihypertensive Heart, Lung, and Blood Institute Joint National Com-
therapy can be initiated during the hospi- mittee on Prevention, Detection, Evaluation, and Treat-
talization with close outpatient follow-up. ment of High Blood Pressure;National High Blood
Pressure Education Program Coordinating Committee.
Although there is often reluctance to dis- Seventh report of the Joint National Committee on Pre-
charge patients with systolic blood pressure vention, Detection, Evaluation and Treatment of High
of more than 180 mm Hg or diastolic blood Blood Pressure:the JNC 7 report [published correction
appears in JAMA. 2003;290(2):197]. JAMA. 2003;
pressure of more than 100 mm Hg, these val- 289(19):2560-2572.
ues in the ambulatory clinic are appropriately 5. Sundström J, Arima H, Jackson R, et al.;Blood Pressure
managed in the outpatient setting.27 A sig- Lowering Treatment Trialists’ Collaboration. Effects of
nificant benefit for hospitalized patients is the blood pressure reduction in mild hypertension:a sys-
tematic review and meta-analysis. Ann Intern Med.
opportunity to recognize severe blood pres- 2015;162(3):184-191.
sure elevations and improve transitional care 6. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/
for the primary care physician.28 ESC guidelines for the management of arterial hyper-
tension:the Task Force for the Management of Arterial
This article updates a previous article on this topic by Hypertension of the European Society of Hypertension
Kessler and Joudeh. 29 (ESH) and of the European Society of Cardiology (ESC).
Eur Heart J. 2013;34(28):2159-2219.
Data Sources: We searched OvidSP, PubMed, Essential 7. Muiesan ML, Salvetti M, Amadoro V, et al.;Working
Evidence Plus, National Guideline Clearinghouse, UpTo- Group on Hypertension, Prevention, Rehabilitation of
Date, and U.S. Preventive Services Task Force guidelines the Italian Society of Cardiology, the Societa’ Italiana
using the key words asymptomatic, elevated blood pres- dell’Ipertensione Arteriosa. An update on hypertensive
sure, hypertension, hypertensive urgency, hypertensive emergencies and urgencies. J Cardiovasc Med (Hager-
emergency, emergency department, guidelines, antihy- stown). 2015;16(5):372-382.
pertensive agents, resistant hypertension, cardiovascular 8. Patel KK, Young L, Howell EH, et al. Characteristics
risk, assessment, management, pharmacologic, treat- and outcomes of patients presenting with hypertensive
ment, white-coat hypertension, screening, compliance, urgency in the office setting. JAMA Intern Med. 2016;
prevalence, evaluation, inpatient. Search dates: Novem- 176(7):981-988.
ber 27, 2015; August 4, 2016; and January 25, 2017. 9. McNaughton CD, Self WH, Zhu Y, Janke AT, Storrow
AB, Levy P. Incidence of hypertension-related emer-
The opinions and assertions contained herein are the
gency department visits in the United States, 2006 to
private views of the author and are not to be construed as
2012. Am J Cardiol. 2015;116(11):1717-1723.
official or as reflecting the views of the U.S. Army Medical
10. Baumann BM, Cline DM, Pimenta E. Treatment of
Department or the U.S. Army Service at large.
hypertension in the emergency department. J Am Soc
Hypertens. 2011;5 (5):366-377.
The Author 11. Weder AB, Erickson S. Treatment of hypertension in
the inpatient setting:use of intravenous labetalol and
ROBERT GAUER, MD, is an assistant professor of fam- hydralazine. J Clin Hypertens (Greenwich). 2010;12(1):
ily medicine at the Uniformed Services University of the 29-33.
Health Sciences, Bethesda, Md. He is also a hospitalist at 12. Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M.
Womack Army Medical Center, Fort Bragg, N.C. Adherence to prescribed antihypertensive drug treat-
ments:longitudinal study of electronically compiled
Address correspondence to Robert Gauer, MD, Womack dosing histories. BMJ. 2008;336(7653):1114-1117.
Army Medical Center, Bldg. 4-2817, Riley Rd., Fort Bragg,
13. Adebayo O, Rogers RL. Hypertensive emergencies in
NC 28310 (e-mail: robertgauer@yahoo.com). Reprints
the emergency department. Emerg Med Clin North Am.
are not available from the author.
2015;33(3):539-551.
14. Weber MA, Schiffrin EL, White WB, et al. Clinical prac-
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April 15, 2017 ◆ Volume 95, Number 8 www.aafp.org/afp American Family Physician 499
Severe Asymptomatic Hypertension
500 American Family Physician www.aafp.org/afp Volume 95, Number 8 ◆ April 15, 2017