St.

Anthony’s College
San Jose, Antique
Nursing Department

NAME OF DRUG Mechanism Indication and Side effects and adverse Nursing
Dosage, route, Of action Contraindication reaction responsibilities
frequency, timing
Generic name: Mechanism of action: Indication: Side effects:  Observe 10 rights of
Olanzapine Mechanism of action  Treatment of schizophrenia CNS: medication
not fully understood;  Treatment of acute mixed or manic Somnolence, dizziness,  Monitor V/S
Brand Name: blocks dopamine episodes associated with bipolar 1 nervousness, headache,  Assess for history of
Zyprexa receptors in the brain, disorder and maintenance of bipolar akathisia, personality allergy to olanzapine.
depresses the RAS; 1 disorder as mono therapy, or disorders, tardive dyskinesia,  Monitor for the many
Route: Blocks serotonin combined with lithium or valproate neuroleptic malignant possible drug interaction
Oral receptor sites; syndrome before beginning therapy.
anticholinergic,  Treatment of agitation associated CV:  Encourage patient to void
Frequency: antihistaminic (H1), and with schizophrenia and bipolar 1 Orthostatic hypotension, before taking the drug to
BID alpha-adrenergic mania(injection) peripheral edema, help decrease
blocking activity may tachycardia anticholinergic effects of
Dosage: contribute to some of its Contraindication: GI: urinary retention.
600mg therapeutic (and Constipation, abdominal pain  Take this drug exactly as
adverse) actions;  Allergy to olanzapine Respiratory: prescribed; do not change
Classification: produces fewer Cough, pharyngitis dose without consulting
 Myeloproliferative disorders
 Antipsychotic extrapyramidal effects Other: your healthcare provider.
 Dopaminergic than most
 Severe CNS depression
Fever, developmental of
blocker antipsychotics. diabetes mellitus
 Comatose states

Use cautiously in elderly or debilitated

patients, or with CV or cerebrovascular
disease, dehydration, seizure disorders,
Alzheimer’s disease, prostate
enlargement, narrow-angle glaucoma,

Eden Marie D. Francisco BSN-3 Cen Janber A. Cabrillos BSN-3