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  • 0.5. ANS Quicksheet PDF

    Transféré par

    Erica Hyeyeon Lee
    98 vues1 page
    This document summarizes several types of G protein-coupled receptors (GPCRs), including their typical locations, effects of ligand binding, and downstream signaling pathways. It describes muscarinic acetylcholine receptors M1-M3 and nicotinic receptors, which are located throughout the central and peripheral nervous systems and mediate various effects. Adrenergic receptors α1, α2, β1-β3 are summarized according to their G protein coupling and effects on tissues like smooth muscle and pancreatic islets. Dopamine receptors D1, D2, D3, D5 are also briefly outlined.

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    This document summarizes several types of G protein-coupled receptors (GPCRs), including their typical locations, effects of ligand binding, and downstream signaling pathways. It describes muscarinic acetylcholine receptors M1-M3 and nicotinic receptors, which are located throughout the central and peripheral nervous systems and mediate various effects. Adrenergic receptors α1, α2, β1-β3 are summarized according to their G protein coupling and effects on tissues like smooth muscle and pancreatic islets. Dopamine receptors D1, D2, D3, D5 are also briefly outlined.

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    98 vues1 page

    0.5. ANS Quicksheet PDF

    Transféré par

    Erica Hyeyeon Lee
    This document summarizes several types of G protein-coupled receptors (GPCRs), including their typical locations, effects of ligand binding, and downstream signaling pathways. It describes muscarinic acetylcholine receptors M1-M3 and nicotinic receptors, which are located throughout the central and peripheral nervous systems and mediate various effects. Adrenergic receptors α1, α2, β1-β3 are summarized according to their G protein coupling and effects on tissues like smooth muscle and pancreatic islets. Dopamine receptors D1, D2, D3, D5 are also briefly outlined.

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    sur 1

    M: GPCR

    CHOLINERGIC RECEPTORS N: ion channels

    RESULTS OF
    RECEPTOR NAME TYPICAL LOCATIONS EFFECTS
    LIGAND BINDING
    !IP3 / DAG CNS Increased cognitive function
    Gq Muscarinic M1
    ! Ca Ganglia Depolarization
    Opening of K channels Heart (Atria) Cardiac inhibition
    Gi Muscarinic M2 Closing of Ca Channels
    "cAMP Presynaptic nerve terminals Inhibition of ACh & NE release
    Smooth muscle Contraction
    !IP3 / DAG
    Gq Muscarinic M3 Vascular endothelium [indirect] Vasodilation (via NO) cGMP
    ! Ca
    Secretory glands Secretion
    Autonomic ganglia Ganglionic transmission
    Nicotinic NN Opening of cation channels,
    Adrenal medulla Secretion of catecholamines
    depolarization
    CNS Undefined
    Nicotinic NM Opening of cation channels,
    Neuromuscular junction Neuromuscular transmission
    depolarization

    ADRENERGIC RECEPTORS
    ADRENERGIC RESULTS OF
    TYPICAL LOCATIONS EFFECTS
    RECEPTORS LIGAND BINDING
    Gq α1 !IP3 / DAG Vascular smooth muscle Contraction
    ! Ca Genitourinary smooth muscle Contraction
    Intestinal smooth muscle Relaxation
    Liver ! Glycogenolysis
    ! Gluconeogenesis
    Gi α2 [autoregulation] " cAMP Presynaptic nerve terminals Inhibition of ACh & NE release
    pancreas: α2 > ß2
    " Ca channels Platelets Aggregation
    + Adipocytes Inhibition of lipolysis
    ! K channels
    Pancreatic islets (β cells) Decreased insulin secretion
    ! Ca Vascular smooth muscle Contraction
    Gs β1 ! cAMP Heart !Heart rate
    "KASH"
    • kidney
    ! Ca !Heart force
    • adipose
    • 
    !AV nodal conduction velocity
    • heart Juxtaglomerular cells !Renin release
    Gs β2 ! cAMP Smooth muscle relax detrusor Relaxation
    cutaneous
    (flush)
    (vascular, bronchial, GIT & GUT)
    Skeletal muscle !Glycogenolysis !Uptake of K+
    Pancreatic islets (β cells) ! Insulin secretion
    Pancreatic islets (α cells) ! Glucagon secretion
    Liver ! Glycogenolysis
    ! Gluconeogenesis
    Gs β3 ! cAMP Adipocytes ! Lipolysis

    DOPAMINE RECEPTORS
    RESULTS OF
    RECEPTOR TYPICAL LOCATIONS EFFECTS
    LIGAND BINDING
    Gs D 1, D 5 ! cAMP Brain
    Smooth muscle of renal vascular bed Relaxation of renal vascular smooth
    muscle
    Gi D2 " cAMP Brain,
    + Effector tissues: especially smooth muscle; Presynaptic nerve terminals
    !K conductance
    Gi D3 " cAMP Brain
    Gi D4 " cAMP Brain, cardiovascular system

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