CUMULATIVE INDEX

BUERGER’S
MEDICINAL CHEMISTRY AND DRUG DISCOVERY
VOLUME I
DRUG DISCOVERY
1. History of quantitative structure – activity relationship.
2. Recent trends in quantitative structure activity realtionships
3. Molecular modeling in drug design.
4. Drug – Target binding forces: Advances in force field approaches
5. Combinatorial library design, molecular similarity, and diversity applications
6. Virtual screening
7. Docking and scoring functions / virtual screening
8. Bioinformatics: Its rol in drug discovery
9. Chemical information computing systems in drug discovery
10. Structure – based drug design
11. X – Ray christallography in drug discovery
12. NMR and drug discovery
13. Mass spectrometry and drug discovery
14. Electron cryomicroscopy of biological macromolecules
15. Peptidomimetics for drug design.
16. Analog design
17. Approaches to the rational design of enzyme inhibitors
18. Chirality and biological activity
19. Structural concepts in the prediction of the toxicity of therapeutical agents
20. Natural products as leads for new pharmaceuticals
21. Index
VOLUME 2
DRUG DISCOVERY AND DRUG DEVELOPMENT
1. Combinatorial chemistry and multiple parallel synthesis
2. High – throughput screening for lead discovery
3. High – throughput pharmacology
4. Application of recombinant DNA technology in medicinal chemistry and drug
discovery.
5. Oligonucleotide therapeutics
6. Therapeutics agents acting on RNA targets
7. Carbohidrate – based therapeutics
8. Membrane transport proteins and drug transport
9. Allosteric proteins and drug discovery
10. Receptor targets in drug discovery and development
11. Nicotinic acetylcholine receptors
12. Large – scale synthesis
13. Principles of drug metabolism
14. Metabolic considerations in prodrug design
15. Retrometabolism based drug design and targeting
16. Drug discovery: The role of toxicology
17. Drug absorption distribution, and eliminations
18. Physicochemical characterization and principles oral dosage form selection
19. The FDA and regulatory issues
20. Intellectual property in drug discovery and biotechnology
21. Index.
VOLUMEN III
CARDIOVASCULAR AGENTS AND ENDOCRINES
1. Cardiac drugs: antianginal, vasodilators, antiarrhythmic.
2. Diuretic and uricosuric agents
3. Myocardial infractions agents
4. Endogenous vasoactive peptides
5. Hematopoietic agents
6. anticoagulants, antithrombotic, and hemostatic
7. Antihyperlipidemic agents
8. Oxygen delivery by allosteric effectors of hemoglobin, blood substitutes, and
plasma expanders.
9. Inhibition of sickle hemoglobin polymerization as a basis for therapeutic
 approach to sickle – cell anemia.
10. Iron chelators and therapeutics uses
11. Thyroid hormones and thyromimetics
12. Fundamental of steroid chemistry and biochemistry
13. Female sex hormones, contraceptives, and fertility drugs.
14. Male sex hormones, analogs, and antagonists.
15. Anti - inflammatory steroids
16. Index
VOLUME IV
AUTOCOIDS, DIAGNOSTICS AND DRUGS FROM NEW BIOLOGY
1. Insulin and hypoglycemic agents
2. Peptide and protein hormones, peptide neurotransmitters, and therapeutic
Agents.
3. Inhibitors of gastric acid secretion
4. Chemokine and cytokine modulators
5. COX – 2 inhibitors and leukotriene modulators
6. Agents acting on prostanoid receptors
7. Retinoids
8. Vitamins.
9. Lifestyle and over – the – counter – drugs
10. Radiopaques
11. Microarrays and gene expression profiling applied to drug research
12. SNPS: Single Nucleotide Polymorphisms and Pharmacogenomics individually
designed drug therapy.
13. Plasmid DNA – mediated gene therapy
14. Index
VOLUME V
CHEMOTHERAPEUTIC AGENTS
1. Molecular biology of cancer
2. Synthetic DNA – targeted chemotherapeutic agents and related tumor –
activated prodrugs
3. Antitumor natural products
4. Radio sensitizers and radioprotective agents
5. Synthetics antiangiogenic agents
6. Future strategies in immunotherapy
7. Selective toxicity
8. Drug resistance in cancer chemotherapy
9. Antiviral agents DNA
10. Antiviral agents RNA viruses (other than HIV) and orthopoxviruses.
11. Rationale of design of anti – HIV drugs
12. Organ transplant drugs
13. Synthetic antibacterial agents
14. Beta – lactam antibiotics
15. Tetracycline, aminoglycoside, macrolide, and miscellaneous antibiotics
16. Antimycobacterial agents
17. Antifungal agents
18. Antimalarial agents
19. Antiprotozoal agents
20. AntihelminticsIndex
VOLUME VI
NERVOUS SYSTEM AGENTS
1. Adrenergics and adrenergic – blocking agents
2. Cholinergics
3. Anticholinergic drugs
4. CNS stimulants
5. Sedative – hypnotics
6. Anticonvulsants
7. Narcotic analgesics
8. Antidepressants
9. Antianxiety agents
10. Antipsychotic agents
11. Investigative agents for use in neurodegenerative conditions
12. Therapeutic and diagnostic agents for Parkinson’s disease
13. Alzheimer’s disease: Search for therapeutics
14. Cognition enhancers
15. Drugs to treat eating and body weight disorders
15. Index