Vous êtes sur la page 1sur 9

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences


Volume 2, Issue 6, 4719-4727. Review Article ISSN 2278 – 4357

HIBISCUS ROSA-SINENSIS: A REVIEW ON ORNAMENTAL PLANT

Pekamwar S. S.*, Kalyankar T.M., Jadhav A.C.

Department of Pharmaceutical Chemistry, School of Pharmacy, S R T M University,


Nanded- 431606 (MS) India.

ABSTRACT
Article Received on
03 September 2013, Nature has been a source of medicinal agents for thousands of year and

Revised on 27 October 2013, a large number of drugs have been isolated from natural sources.
Accepted on 14 November Higher plants, as source of medicinal compounds, have continued to
2013
play an important role in the maintenance of human health since
ancient times. Over 50% of all modern clinical drugs are of natural
*Correspondence for
Author:
product origin and have significant role in drug development programs
in the pharmaceutical industry. Hibiscus rosa-sinensis, an ornamental
*Dr. S. S. Pekamwar,
plant; posses different pharmacological activities & is used for
Director, School of Pharmacy,
treatment of different diseases. A review of pharmacological potential
S R T M University,
Nanded-431606 (MS) India of Hibiscus rosa-sinensis plant is discussed in brief in this article.
sspekamwar@gmail.com KEYWORDS: Hibiscus rosa-sinensis, phytochemistry,
pharmacology.

INTRODUCTION
Nature has been a source of medicinal agents for thoughts of years and a remarkable number
of drugs have been isolated from natural source. Over the years, WHO advocated traditional
[1]
medicines as safe remedies for aliments of both microbial and non-microbial origins.
“World Health Organization” has recommended that traditional health and folk medicine
systems are proved to be more efficient in health problems worldwide. India is one of the
nations blessed with a rich heritage of traditional medical systems and rich biodiversity to
complement the herbal needs of the treatment administered by these conventional medical
systems. The accepted Indian systems of medicine are Ayurveda, Unani and Siddha, which
uses herbs and natural resources in the formulations. [2]

www.wjpps.com 4719
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

Hibiscus rosa sinensis L (Malvaceae) is an ornamental plant often a hedge or fence plant. It is
native to china and is also seen in India and Philippines. This plant having several forms and
varying colors of flowers. This is a national flower of Malaysia. [3]

Figure 1: Hibiscus rosa sinensis Plant


Scientific Classification
Kingdom - Plantae
Subkingdom - Tracheobionta
Super division - Spermatophyta
Division - Magnoliophyta
Class - Magnoliopsida
Subclass - Dilleniidae
Order - Malvales
Family - Malvaceae
Genus - Hibiscus
Species - Hibiscus rosa-sinensis

PHYTOCHEMICAL REVIEW
Different extract of Hibiscus rosa-sinensis plant revealed the presence of alkaloids,
glycosides, fatty materials, reducing sugars, resin, sterols and the lack of tannins and
Saponins. Isolation of β-sitosterol, taraxeryl acetate and four uncharacterized compounds
which included an alkaloid and three sterols has been reported in the leaves. The leaves of
Hibiscus rosa-sinensis were also investigated for their fatty alcohol, fatty acids and
hydrocarbon content. Two cyclic acids viz., malvalic and sterculic are also identified. [2]

www.wjpps.com 4720
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

Flowers contain vitamins, flavonoids, ascorbic acid, niacin, riboflavin, thiamine and
cyaniding diglucoside. Quercetin-3-diglucoside, cyanidin-3-sophoroside-5-glycosides, 3, 7-
diglucoside, cyanidin-3, 5-diglucoside have been isolated from deep yellow flowers. [4]

Table 1: Phytochemical Review

Sr.no. Plant part Constituent reported


1 Flowers[5] Thiamine, Riboflavin, Niacin and Ascorbic acid, Apigenidin,
citric acid, fructose, glucose, oxalic acid, pelargonidin, quercetin.
2 Leaves[2] Alkaloids, glycosides, reducing sugars, fatty materials, resin and
sterols, Fatty acids, fatty alcohol, and hydrocarbon, sterculic and
malvalic acid.
3 Stems[6] Teraxeryl acetate, ß-sitosterol and the cyclicacids sterculic and
malvalic acids.
4 Roots[7] Glycosides, tannins, phytosterols, fixed oils, fats, proteins, amino
acids, flavonoids, Saponins, gums and mucilage.

PHARMACOLOGICAL REVIEW
Hibiscus rosa sinensis (Malvaceae) is a perennial ornamental shrub available throughout
India. Various parts of this plant like flowers, leaves and roots have been known to possess
medicinal properties like oral contraceptive, laxative, aphrodisiac, menorrhagic etc. [8]

Several articles and ancient literature have shown that the flowers of this plant possess
antifertility activity. [9] The aqueous ethanolic extract of aerial parts of this plant was reported
for its use in constipation and diarrhea. [10] In traditional medicine, the leaves of the plant are
used in fatigue and skin disease. Powdered root of the plant is given for menorrhagia and the
[11]
fresh root juice for gonorrhea. Flowers of the plant are used in diabetes, epilepsy,
bronchial catarrh and leprosy. [12, 13]

An infusion of the petal is widely used in Ayurvedic medicine in India as a demulcent


refrigerant drink in fever [14] and decoction is given in bronchial catarrh. [15] Previous studies
showed that the plant possess anti-phologistic, anti-diarrhetic and anticomplementary
activity. [16]

www.wjpps.com 4721
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

It has been reported that the plant flower possess anti-spermatogenic and androgenic [17] anti-
tumour activity. [18] The use of flower to treat heart disorders and anti-diabetic activity has
also been confirmed. [19, 20]

Table 2: Pharmacological Review


Sr Plant part Activity reported Model used Remark
no
1 Flower Antidiabetic Activity Steptozotocin Found to be active
induced[21]
Alloxan induced[22] Found to be active
Hair growth potential In vivo & in vitro Exits potency
methods[23]
Anticonvulsive Mice[24] The brain content of
Activity GABA & serotonin
were raised.
[25]
Antifertility Activity Rats Antifertility effects
in rats
Abortifacient Rats[26] A dose of 186mg/kg
Activity were active
[27]
Antiestrogenic Albino rats A reduction in
Activity weights of the
pituitary, ovary &
uterus.
Guinea pigs[28] Found to be active.

Anti-implantation Female albino Leading to 80%


Activity rats[29] reduction In the
implantation site on
10th day of
pregnancy.
Antilithiatic potential In vitro assay[30] A very good
inhibitory effect
against crystal
nucleation, growth

www.wjpps.com 4722
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

& aggregation.
Cardio protective Wistar albino The determination of
[31]
effect rats baseline changes in
cardiac endogenous
antioxidants.
Wound healing Rats[32] Found to be active
activity
2 Leaves Antifungal Activity Active on Inhibition found to
Rhizoctonia solani be 34.50%
Mycelial
inhibition[33]
Anti-inflammatory Carragenin induced Found to be active
activity pedal edema of
rats[34]
Hair growth potential In vivo & in vitro Found to be more
methods[23] potent than flower
extract.
Analgesic Activity Mice[34] Found to be active.
Antipyretic Activity Brewer’s yeast Dose of 100mg/kg
induced pyrexia was active.
[34]
rats
Antibacterial Activity Clinical isolates of Found to be active
bacteria[35]
Antioxidant and In vivo & in vitro Found to be active
scavenging activity assay[36]
3 Stem Juvenile Harmone Dysdercus Found to be active
Activity cingulatus[37]
4 Root Antipyretic activity Swiss albino Found to be active
rats[38]
Analgesic activity in Swiss albino Found to be active
rats[38]
Antiulcer Activity Pyloric ligation Found to be active
method in rats[39]

www.wjpps.com 4723
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

Antifertility Activity female albino Found to be active


rats[40]
Hypolipidaemic Rats[41] Found to be active
Activity
5 Aerial parts CNS depressant Mice[23] Dose of 500mg/kg
Activity was active
Hypothermic Activity Mice[23] Found to be active
Hypotensive Activity Dogs[42] A dose of 50mg/kg
was active.
Antipyretic Activity Mice[23] A dose of 500mg/kg
was active.

CONCLUSION
Hibiscus rosa sinensis possess many properties and this plant may procured at large scale for
providing herbal alternative to many diseases. This study shows that on biochemical basis
plant used in the treatment and prevention of various diseases and disorders. The
phytochemical screening on qualitative analysis shows that the plant is rich in alkaloids,
terpenoids, flavonoids, glycosides, reducing sugar, Fatty materials, saponins, gums and
mucilage.

ACKNOWLEDGEMENT
Authors are thankful to the School of Pharmacy, S R T M University, Nanded, for providing
necessary facilities.

REFERENCES
1) WHO 1978. The promotion and development of traditional medicine. Technical report
series.pp-622.
2) Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Hibiscus rosa sinensis Linn –
‘‘Rudrapuspa’’: A Review. Journal of Pharmacy Research, 2009; 2(7): 1168-1173.
3) Bhaskar A. Evaluation of hypolipidaemic activity of Hibiscus rosa sinensis L. Journal of
Pharmacy Research, 2011; 4(10): 3293-3294.
4) Srivastava DN, Bhatt SK, Udupa KN. Gas chromatographic identification of fatty acids,
fatty alcohols and hydrocarbons of Hibiscus rosa sinensis leaves. J. Amer. Oil Chem Soc,
1976; 53: 607.

www.wjpps.com 4724
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

5) The Wealth of India – Raw Materials, Vol-5, Council of Scientific and Industrial
Research, New Delhi, 1992, pp. 91-92.
6) Khare CP, Enclyclopedia of Indian Medicinal Plants. New York; Springer- Verlag Berlin
Heidelberg: 2004, PP. 248-249.
7) Soni D, Gupta A, Solanki R, Jana GK. Pharmacognostical, phytochemical and
physiochemical findings over the root extract of Hibiscus rosa sinensis [Malvaceae]. J.
Nat. Prod. Plant Resour, 2011; 1 (4):73-79.
8) Satyavati GV, Gupta AK, Tondon N. Medicinal plants of India, New Delhi 7 Indian
Council of Medical Research, 1987 Vol.2.
9) Batta SK, Santhakumari G. The anti-infertility effect of Ocimum sanctum and Hibiscus
rosa sinensis. Indian J Med Res, 1970; 59: 777–781.
10) Gilani AH, Bashir S, Janbaz KH, Shah AJ. Presence of cholinergic and calcium channel
blocking activities explains the traditional use of Hibiscus rosa sinensis in constipation
and diarrhea. J Ethnopharmacol, 2005; 102:289-294.
11) The Wealth of India. Raw materials, vol. 5. New Delhi; CSIR: 1959, pp. 91.
12) Kasture VS, Chopde CT, Deshmukh VK. Anticonvulsant activity of Albizzia lebbeck,
Hibiscus rosa sinensis and Butea monosperma. J Ethnopharmacol, 2000; 71(1-2):65-75.
13) Indian medicinal plants. A compendium of 500 species, vol. 2. Orient Longman: 1995,
pp.149
14) Chatterjee A, Pakrashi SC. The Treatise of Indian Medicinal Plants, 1992; 2: pp.180.
15) Chopra RN, Chopra IC, Varma BS.Supplement to Glossary of Indian Medicinal Plants.
New Delhi, India 1969, pp.39.
16) Shimizu N, Tomoda M, Suzuki T, Takada K. Plant mucilages. XLIII. A representative
mucilage with biological activity from the leaves of Hibiscus rosa sinensis. Biological
and Pharmaceutical Bulletin. 1993; 16: 735–739.
17) Reddy CM, Murthy DRK., Patil SB. Antispermatogenic and androgenic activities of
various extracts of Hibiscus rosa sinensis in albino mice. Indian Journal of Experimental
Biology, 1997; 35:1170– 1174.
18) Serrame E, Lim Sylianco CY. Anti-tumour promoting activity of decoctions and
expressed juices from Philippine medicinal plants. Philippine Journal of Science, 1995;
124: 275–281.
19) Sharma UD. Cure of heart diseases with Ayurvedic drugs. Sachitra Ayurved, 1994; 47:
95–96.

www.wjpps.com 4725
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

20) Alam MM, Siddiqui MB, Hussain W. Treatment of diabetes through herbal drugs in rural
India. Fitoterapia, 1990; 61: 240–242.
21) Sachdewa A, Khemani LD. Effect of Hibiscus rosa sinensis Linn. Ethanol flower extract
on blood glucose and lipid profile in streptozotocin induced diabetes in rats. Journal of
Ethno pharmacology, 2003; 89(1): 61-66.
22) Venkatesh S, Thilagavathi J, Shyam sundar. Antidiabetic activity of flowers of Hibiscus
rosa sinensis. Fitoterapia, 2008; 79(2): 79-81.
23) Bhakuni OS, Dhar ML, Dhar MM, Dhavan BN, Mehrotra BN. Screening of Indian plants
for biological activity, Part II. Indian J. Exp. Biol., 1969; 7: 250-262.
24) Kasture VS, Chopde CT, Deshmukh VK. Anticonvulsive activity of Albizzia lebbeck,
Hibiscus rosa sinensis and Butea monosperma in experimental animals. Journal of Ethno
pharmacology, 2000; 71: 65–75.
25) Batta SK, Santhakumari G. The antifertility effect of Ocimum sanctum and Hibiscus rosa
sinensis, Indian Journal of Medical Research, 1970; 59:77-78.
26) Singh MP, Singh RH, Udupa KN. Antifertility activity of a benzene extract of Hibiscus
rosa sinensis flowers in female albino rats. Planta Med., 1982; 44: 171-174.
27) Prakash AO, Glycogen contents in the rat uterus response to Hibiscus rosa sinensis
extracts, Experientia, 1979; 35(8): 1122-1123.
28) Murthy DR, Reddy CM and Patil SB. Effect of benzene extract of Hibiscus rosa-sinensis
on the estrous cycle and ovarian activity in albino mice, Biology Pharm. Bulletein,
1997;20(7): 756-758.
29) Kholkute SD, Udupa KN. Effects of Hibiscus rosa sinensis on pregnancy of rats. Planta
Med, 1976; 29: 321-329.
30) Nirmaladevi R, Kalpana S, Kavitha D, Padma PR. Evaluation of Antilithiatic potential
of Hibiscus rosa-sinensis Linn, in vitro. Journal of Pharmacy Research, 2012; 5(8): 4353-
4356.
31) Karunakaran K Gauthaman, Mohamed TS Saleem, Peter T Thanislas, Vinoth V Prabhu,
Karthikeyan K Krishnamoorthy, Niranjali S Devaraj, Jayaprakash S Somasundaram.
Cardio protective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model
of myocardial ischemic reperfusion injury in rat. BMC Complementary and Alternative
Medicine, 2006; 6: 32.
32) Nayak SS, Sivachandra R, Orette FA, Chalapathi Rao AV. Effects of Hibiscus rosa
sinensis L (Malvaceae) on Wound Healing Activity: A Preclinical Study in a Sprague
Dawley Rat B. The International Journal of Lower Extremity Wounds, 2007; 6(2): 76-81.

www.wjpps.com 4726
Pekamwar et al. World Journal of Pharmacy and Pharmaceutical Sciences

33) Renu. Fungitoxicity of leaf extracts of some higher plants against Rhizoctonia solani
kuehn. National Academic Science Letters, 1983; 6(8): 245-246.
34) Singh NR, Nath AK, Agarwal RP. A pharmacological investigation of some indigenous
drugs of plants origin for evaluation of their antipyretic, analgesic and anti-inflammatory
activities. J. Res. Indian Med. Yoga Homeopathy, 1978; 13: 58-62.
35) Borhan Uddin, Tareq Hossan, Sudip Paul, Tanjir Ahmed, Taslima Nahar, Sohel Ahmed.
Antibacterial activity of the ethanol extracts of Hibiscus rosa-sinensis leaves and flowers
against clinical isolates of bacteria. Bangladesh Journal of Life Sciences, 2010; 22(2): 65-
73.
36) Faten R. Abdel Ghaffar, Ibrahim A. El-Elaimy.In vitro, antioxidant and scavenging
activities of Hibiscus rosa sinensis crude extract. Journal of Applied Pharmaceutical
Science, 2012; 2(1): 51-58.
37) Prakash AO, Mathur A, Mehta H, Mathur A. Concentrations of Na+ and K+ in serum
and uterine flushing of ovariectomized, pregnant and cyclic rats when treated with
extracts of Hibiscus rosa sinensis flowers. Journal of Ethno pharmacology, 1990; 28:
337-347.
38) Soni D, Gupta A. An evaluation of antipyretic and analgesic potentials of aqueous root
extract of Hibiscus rosa sinensis Linn. (Malvaceae), Int. J. Res. Phytochem. Pharmacol,
2011; 1(3): 184-186.
39) Anita Gnana Kumari AV, Palavesam A, Anbu Jeba Sunilson J, Anandarajagopal,
M.vignesh, Parkavi J. Preliminary Phytochemical and Antiulcer studies of Hibiscus rosa
sinensis Linn. International Journal of Green Pharmacy, 2012; 4(1): 41-43.
40) Neeru Vasudeva, Sharma SK. Post-Coital Antifertility Activity of Hibiscus rosa-sinensis
Linn. Roots, Evid Based Complement Alternate Med, 2008; 5(1): 91–94.
41) Kumar V, Singh P, Ramesh Chander, Farzana Mahdi, Singh S, Singh R, Khanna AK,
Sxena JK, Abhas Ali Mahdi, Singh VK, Singh RK. Hypolipidaemic activity of Hibiscus
rosa sinensis roots in rats, Indian journal of biochemistry and biophysics, 2009; 46: 507-
510.
42) Ross IA. Medicinal Plants of the World, 2nd edition Vol-I, Library of Congress
Cataloging in Publication data, America, pp. 253-266.

www.wjpps.com 4727

Vous aimerez peut-être aussi