The Fermentation of Pyruvate

ªReview: In the process of glycolysis, a net profit of two ATP was produced, two NAD+
were reduced to two NADH + H+, and glucose was split into two pyruvate molecules.
ªWhen oxygen is not present, pyruvate will undergo a process called fermentation. In the
process of fermentation the NADH + H+ from glycolysis will be recycled back to NAD+ so that
glycolysis can continue.

In the process of glycolysis, NAD+ is reduced

to form NADH + H+. If NAD+ is not present,
glycolysis will not be able to continue. During
aerobic respiration, the NADH formed in
glycolysis will be oxidized to reform NAD+ for
use in glycolysis again.
When oxygen is not present or if an organism
is not able to undergo aerobic respiration,
pyruvate will undergo a process called
fermentation. Fermentation does not
require oxygen and is therefore anaerobic.
Fermentation will replenish NAD+ from the
NADH + H+ produced in glycolysis.

One type of fermentation is alcohol

fermentation. First, pyruvate is
decarboxylated (CO2 leaves) to form
acetaldehyde. Hydrogen atoms from NADH +
H+ are then used to help convert acetaldehyde
to ethanol. NAD+ results.
Facultative anaerobes are organisms that
can undergo fermentation when deprived of
oxygen. Yeast is one example of a facultative
anaerobe that will undergo alcohol
fermentation.

Some organisms, such as some bacteria, will

undergo lactate fermentation. Two
pyruvates are converted to two lactic acid
molecules, which ionize to form lactate. In
this process two NADH + H+ are converted to
two NAD+.
Our muscle cells can undergo this process
when they are in oxygen debt. If enough
oxygen is not present to undergo aerobic
respiration, pyruvate will undergo lactic acid
fermentation.

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