Pathophysiology of BREAST CANCER

Predisposing factor Precipitating factor

Gender M<F Life style
Genetic/Hereditary Cell death = Cell replace
Sexual practice
Virus
Environmental
Response with carcinogen Chemical
Physical

Damage/Change in
genetic material [DNA]

Hyperplasia

Recurrent injury
Absorb Surrounding ↓
Nutrients metaplasia

Cell starvation Prolonged injury

↓
Mutation
Hypothalamus ↓
Loss of P53

Lipolysis
Loss of apoptysis
↓
Fat loss Dysplasia
↓
anaplasia
Weakness
Decreased T-CELL BREAST
↓ ↓
Weight loss Neoplasia Lump
↓ ↓
“Promotion” CANCER Tail of Spence
Anorexia ↓
Orange peel
1cm growth dumpling
Wasting syndrome ↓ ↓
Angio genesis growth Nipple inversion
factor
Cachexia

Hypoxia Anoxia Inflammation → kinis → PAIN

↓ ↓
Lactic acid Cell Death
↓ Pyrogen → Recurrent fever
Pain