MBBS THEORY SYLLABUS ( 120 HRS )

Sr. Main Portion to be covered in 1 Term Staff Date

no topic lecture
1. General History & scope of pathology, in
pathology brief history, pr
30 HRS esent state & future, ethical
aspects.
Normal cell structure, etiopath-
ogenesis, reversible cell injury
(types, sequential changes,
cellular swellings, vacuolation,
hyaline & mucoid changes).
Irreversible cell injury ( types of
necrosis & gangrene, autolysis,
apoptosis ).
Pathologic calcification,
Intracellular accumulations
(fatty change, protein &
glycogen accumulations)
Pigment metabolism - melanin,
hemosiderin, Ochronosis,
Lipofuscin, Porphyrias
Acute inflammation –Historic
facts, Definition, features,
causes, vascular events.

Cellular events. Inflammatory

cells and mediators
Phagocytosis
Morphologic variants of acute
 inflammation.
Chronic inflammation ( causes,
types, classification, nonspecific
& granulomatous with
examples).
Repair, wound healing by
primary and secondary union,
factors promoting and delaying
the process, healing a sp. Site –
ex. Healing of fracture.
IMMUNO General concepts,
PATHOLO hypersensitivity ( types I & II)
GY
Hypersensitivity types III & IV
Primary immunodeficiency,
secondary immunodeficiency
including HIV ( AIDS – etiology,
modes of transmission,
diagnostic procedures, handling
of infected material & health
education ).
Autoimmne disorders ( basic
concepts, classification, SLE,
organ specific & non – organ sp.
Eg. – polyarteritis nodosa,
Hashimoto’s dis, Sjogren’s
polymyositis, dermatomyositis,
scleroderma ).

Amyloidosis

CIRCULAT Hyperemia & CVC ( lung, liver,

ORY spleen)
DISTURBA Edema – Pathogenesis and types
NCES.
Thrombosis
 Infarction, Embolism
Shock – Pathogenesis,
types,morphologic changes.
Infectious Mycobacterial diseases -
Diseases Tuberculosis
Leprosy & Syphillis
NEOPLASI Atrophy, hypertrophy,
A hyperplasia, aplasia, hypoplasia,
dysplasia, metaplasia,
malformation, agenesis.
Neoplasia : classification,
histogenesis, biological behavior
(Difference between Benign &
malignant) carcinoma &
sarcoma.
Carcinogenesis : Chemical
Viral and Radiation
Oncogenes and cancer
Paraneoplastic syndromes,
Tumor markers.
Precancerous lesions
Diagnostic methods : Biopsy,
Exfoliative cytology, FNAC,
Cryostat, Flow cytometry, PCR.
2. Genetic Basic concepts of genetic
Disorders. disorders, Storage disorders.
Cytogenetic disorders: Down
Syndrome, Turners & Klinefelter
syndrome.
HEMATOLOGY Constituents of blood, bone
marrow, Hematopoesis. Anemia
: classification, clinical features,
lab ∆sis. Red Cell Indices.
 Nutritional anemias : Iron
deficiency anemia,
Megaloblastic anemias
Hemolytic anemias :
classification & investigations.
Hereditary Spherocytosis, HE,
Enzyme deficiencies.
Thalassemias
Sickle cell anemia
Acquired Hemolytic anemia:
Alloimmune, Autoimmune, Drug
Induced, Microangiopathic.
Leucocytic disorders,
Leucocytosis, Leucopenia,
Leukemoid Reaction
Acute Leukemias – Classn &
Diagnosis
Myeloproliferative disorders:
(CML, PV, MF)
Multiple Myeloma

Blood transfusion : grouping,

cross matching, blood
transfusion reactions,
transmissible infections, blood
components, plasma-pheresis.
Hemorrhagic disorders – vW
disease, Hemophilia, ITP

Respirator Introduction, COPD –

y system Emphysema, Chronic Bronchitis
7 Hrs COPD – Bronchial Asthma,
 Bronchiectasis
Restrictive Lung diseases –
Pneumoconiosis CWP, Silicosis
Asbestosis, Beryliosis
Atelectasis, Hyaline membrane
disease, ARDS
Pulmonary Infections – Lobar
Pneumonia, Bronchopneumonia,
Pulmonary TB – Primary and
Secondary & Pleuritis
Lung Tumors

Cardiovascular Vascular dis : Atherosclerosis –

Pathology – 8 pathogenesis & risk factors,
hours monckeberg’s medial
calcification.
Morphology of Atherosclerosis
Aneurysm, Arteritis, tumors of
blood vessels.
Ischemic Heart Disease.
Endocarditis
RHD, Pericarditis
Hypertension, hypertensive
heart disease
Cardiomyopathy
Congenital Heart Disease.
Renal Introduction and Clinical
Pathology 10 manifestations of Renal Diseases
hours - Glomerular syndromes, Renal
Failure
Pathogenesis of Glomerular
 injury
Nephritic syndrome – Ac Post
Streptococcal GN & RPGN
Nephrotic Syndrome –
Membranous, MCD, FSG, MP,
IgA , Others
Chronic GN.
Diabetic Nephropathy.
Renal vascular disorders- kidney
changes in hypertension.
Tubulointerstitial dis : acute
tubular necrosis, Ac & Chronic
pyelonephritis.
Urolithiasis & obstructive
uropathy, hydronephrosis Renal
tumors : RCC, Nephroblastoma.
Cystic Diseases of the Kidney.
Urinary bladder : inflammatory
lesions & tumors.
GI Pathology Oral pathology : ulcers,
leukoplakia, Ca – oral cavity,
diseases & tumors of salivary
gland ( mixed, Warthin’s).
Esophagus : inflammatory &
functional disorders,
precancerous lesions, tumors.
Stomach : gastritis, ulcer
 Carcinoma Stomach

Inflammatory lesions of small

intestine : typhoid, TB, Crohn’s,
malabsorption synd.

Inflammatory dis of large

intestine : amoebic colitis,
bacillary dysentery, Ulcerative
colitis

Ac Appendicitis, Mesenteric
thrombosis, enterocolitis,
diverticulosis, Hirschprung dis.
Tumors & tumor like conditions
of small & large intestine :
polyps, carcinoid, carcinoma,
lymphoma.
Pancreatitis & pancreatic tumors
: a) exocrine, b) endocrine.
HEPATOBILIAR Jaundice : types,
Y PATHOLOGY etiopathogenesis, ∆sis.

Hepatitis : acute , chronic,

neonatal.
Alcoholic liver disease
Cirrhosis : postnecrotic,
alcoholic, metabolic, portal
hypertension
Liver abscess: pyogenic parasitic
, amoebic.
Tumors of liver
 Diseases of gall bladder :
cholecystitis, cholelithiasis,
carcinoma.
Lymphoreticula Lymphadenitis : nonspecific &
r system and granulomatous. Causes of lymph
Spleen. node enlargement , reactive
hyperplasia
Primary tumors : Hodgkin’s
lymphoma.
NHL,
Causes of splenic enlargements.
Thymomas
Dis of cervix : cervicitis, cervical
carcinoma.

Endometrial hyperplasia &

carcinoma
Adenomyosis, Endometriosis,
Leiomyoma
Trophoblastic disease :
hydatidiform mole,
choriocarcinoma & lab ∆sis.
Ovarian Tumors
Prostate : nodular hyperplasia &
carcinoma.
Testicular Tumors
Diseases of penis : inflammatory,
premalignant & tumors.
Mastitis, abscess, fibrocystic
disease, fibroadenoma.
Carcinoma Breast, Phylloides
tumor.
Osteomyelitis, - acute, chronic,
tuberculous , mycetoma.
Metabolic diseases : rickets,
osteomalacia, osteoporosis,
hyperparathyroidism, paget’s
disease.
Tumors : classification, benign,
malignant, metastatic & synovial
sarcoma.
Arthritis : suppurative,
rheumatoid, osteoarthritis, gout,
TB.
Diabetes mellitus : types,
pathogenesis, pathology, lab
∆sis.
Non-neoplastic lesions of
thyroid : iodine deficiency goiter,
thyrotoxicosis, myxedema,
Autoimmune Thyroiditis –
Hashimotos
Graves Disease, Thyroiditis – Sub
Acute, Riedels
Tumors of thyroid : adenoma ,
carcinoma, ( papillary, follicular,
medullary, anaplastic)
Adrenal diseases: cortical
hyperplasia, TB, tumors of cortex
& medulla.
Inflammation & infections : TB
meningitis, pyogenic meningitis,
viral meningitis, brain abscess.
TB, Cysticercosis.
CNS tumors : Meningioma,
astrocytoma, Oligodendroglioma
Medulloblastoma,
Neuroblastoma
Skin tumors : squamous cell ca,
 basal cell ca,
Melanoma
Eye and Inflammations, Retinoblastoma
Ocular
adnexa
Hemoglobin estimation
3. ESR, PCV, LE cell,
Clinical Peripheral Smear examination,
pathology 10 Reticulocyte count,Blood Indices
hrs
Study of bone marrow & marrow
transfusion.
Blood grouping : concept of
blood group, selection of donor,
major & minor cross matching.
Blood transfusion, reactions,
diseases transmitted by blood
transfusion, coomb’s test.
CSF analysis
Semen analysis
Urine examination
Exfoliative cytology, FNAC, FNAB
Body fluids - pleural, peritoneal,
synovial, pericardial fluids
LFT, RFT, TFT